Reviewed, UniProtKB/Swiss-Prot B3QWX6 (KHSE_CHLT3)

Names and origin

Protein names

Recommended name:
    Homoserine kinase
      Short name=HSK
      Short name=HK
    EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Ctha_0872

Organism

Chloroherpeton thalassium (strain ATCC 35110 / GB-78) [Complete proteome] [HAMAP]

Taxonomic identifier

517418 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chloroherpeton

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphorylation Inferred from electronic annotation. Source: InterPro threonine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP homoserine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 319	319	Homoserine kinase HAMAP MF_00384		PRO_1000122409
Regions
	Nucleotide binding	100 – 110	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	B3QWX6-1 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: 842869BC5BB59DAE	FASTA	319	33,547
	10 20 30 40 50 60 MKQVTGFAPA SVGNVACGFD VLGFALTEPG DEVTVSFTDD ENSPAQVIIS KIIGDGGALP 70 80 90 100 110 120 TDPYKNTASI VVIKFLEFLK THKGIEQSGT FSIELKKNLP LSSGMGSSAS SAAAALIAAN 130 140 150 160 170 180 SLLGSPCTKM ELVPFVMEGE RIACGSIHAD NAAPAMLGNF ILTRSYDPLD LIPISTPPEL 190 200 210 220 230 240 YCSLVHPHIE VPTSHARSIL KKEIALSSAV RQWGNVGALV AGLLRCDYEL IGRALEDVVA 250 260 270 280 290 300 EPVRAPLIPG FYDVKHAALD AGALGGSIAG SGPSIFAFSD SLAKAETIAK AMQETFRKVS 310 NLESDIWFCP VSREGSRIL

References

[1]

"Complete sequence of Chloroherpeton thalassium ATCC 35110." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F. , Overmann J., Bryant D.A., Richardson P. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001100 Genomic DNA. Translation: ACF13340.1.
RefSeq	YP_001995787.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6421924.
GenomeReviews	Gene locus Ctha_0872 in contig CP001100_GR.
KEGG	cts:Ctha_0872.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	CGSAHAD.
Family and domain databases
HAMAP	MF_00384. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP_bd_CS. IPR000870. Homoserine_kin. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000676. Homoser_kin. 1 hit.
PRINTS	PR00958. HOMSERKINASE.
TIGRFAMs	TIGR00191. thrB. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KHSE_CHLT3

Accession

Primary (citable) accession number: B3QWX6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 2, 2008
Last modified:	November 3, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)