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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Chloroherpeton thalassium (strain ATCC 35110 / GB-78)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Ctha_0830
OrganismiChloroherpeton thalassium (strain ATCC 35110 / GB-78)
Taxonomic identifieri517418 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChloroherpeton
Proteomesi
  • UP000001208 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 43HelicalUniRule annotationAdd BLAST21
Transmembranei72 – 92HelicalUniRule annotationAdd BLAST21
Transmembranei94 – 114HelicalUniRule annotationAdd BLAST21
Transmembranei139 – 159HelicalUniRule annotationAdd BLAST21
Transmembranei170 – 190HelicalUniRule annotationAdd BLAST21
Transmembranei201 – 221HelicalUniRule annotationAdd BLAST21
Transmembranei238 – 258HelicalUniRule annotationAdd BLAST21
Transmembranei281 – 301HelicalUniRule annotationAdd BLAST21
Transmembranei345 – 365HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000906101 – 368Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST368

Interactioni

Protein-protein interaction databases

STRINGi517418.Ctha_0830.

Structurei

3D structure databases

SMRiB3QWT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B3QWT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYYLLSYVR EIYDPPGLGV INYITFRAGA AAVTALIIIL VFGPKIIRFL
60 70 80 90 100
RDKVIEPIKE EAPEEHRKKV NIPTMGGLMI ILAIEVSGLL WAKIAEPFVW
110 120 130 140 150
MVLLAIIWMG AVGFVDDYRK VVLKIKGGLS GRYKIVGQVA LGLIIGGYTF
160 170 180 190 200
FDPTLSVLLS KTTVPFIKEI TVDYGIWYIP LAIFIVTAVS NAVNLTDGLD
210 220 230 240 250
GLAAGSTAIS VFSLAGFAYL TGNVKFAEYL NITYIPGAGE VTILSMAIVA
260 270 280 290 300
ACIGFLWFNS NPAEVFMGDT GSLALGSAVA VIALLIKKEL LLPLIAGIFF
310 320 330 340 350
IETLSVIIQR GYFKYTKRRD GEGKRIFRMA PLHHHFQKKG WAEQKIVIRF
360
WIIEVLLVLT SLLTLKLR
Length:368
Mass (Da):40,624
Last modified:September 2, 2008 - v1
Checksum:iC80A7B478906C9C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001100 Genomic DNA. Translation: ACF13298.1.
RefSeqiWP_012499382.1. NC_011026.1.

Genome annotation databases

EnsemblBacteriaiACF13298; ACF13298; Ctha_0830.
KEGGicts:Ctha_0830.

Similar proteinsi

Entry informationi

Entry nameiMRAY_CHLT3
AccessioniPrimary (citable) accession number: B3QWT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: June 7, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families