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B3QW96

- UPPP_CHLT3

UniProt

B3QW96 - UPPP_CHLT3

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Chloroherpeton thalassium (strain ATCC 35110 / GB-78)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciCTHA517418:GHTO-745-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:Ctha_0740
    OrganismiChloroherpeton thalassium (strain ATCC 35110 / GB-78)
    Taxonomic identifieri517418 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChloroherpeton
    ProteomesiUP000001208: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283Undecaprenyl-diphosphatasePRO_1000197359Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi517418.Ctha_0740.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei40 – 6021HelicalUniRule annotationAdd
    BLAST
    Transmembranei85 – 10521HelicalUniRule annotationAdd
    BLAST
    Transmembranei117 – 13721HelicalUniRule annotationAdd
    BLAST
    Transmembranei196 – 21621HelicalUniRule annotationAdd
    BLAST
    Transmembranei232 – 25221HelicalUniRule annotationAdd
    BLAST
    Transmembranei258 – 27821HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiMEQINIG.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B3QW96-1 [UniParc]FASTAAdd to Basket

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    MDIIQAIVLG IIQGLTEFLP ISSSAHLRIF PALLGWDDPG AAFTAIIQIG    50
    TLAAVLIYFY QDILRITSAT ISGLVNRNPF GSQDSRMGWM ISAGTIPIVV 100
    LGLLFKKNIE TTFRSLYIIS GSLILLALVL MYAEYLVKKR EARGEKMLSL 150
    DKVDWKEAII IGLAQSLALI PGSSRSGTTI TGGLFLGMTR ETAARFSFLL 200
    SLPAVFAAGV YQLLKVWPEL MASGDELVNL TVATVVSGVI GYASIAFLLD 250
    YLKKHSTYLF IIYRILLGVF LLAMLSMGKL EAF 283
    Length:283
    Mass (Da):30,837
    Last modified:September 2, 2008 - v1
    Checksum:iDD7C07DD56491219
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001100 Genomic DNA. Translation: ACF13209.1.
    RefSeqiYP_001995656.1. NC_011026.1.

    Genome annotation databases

    EnsemblBacteriaiACF13209; ACF13209; Ctha_0740.
    GeneIDi6421786.
    KEGGicts:Ctha_0740.
    PATRICi21430089. VBIChlTha99257_0871.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001100 Genomic DNA. Translation: ACF13209.1 .
    RefSeqi YP_001995656.1. NC_011026.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 517418.Ctha_0740.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF13209 ; ACF13209 ; Ctha_0740 .
    GeneIDi 6421786.
    KEGGi cts:Ctha_0740.
    PATRICi 21430089. VBIChlTha99257_0871.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi MEQINIG.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci CTHA517418:GHTO-745-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Chloroherpeton thalassium ATCC 35110."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F.
      , Overmann J., Bryant D.A., Richardson P.
      Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35110 / GB-78.

    Entry informationi

    Entry nameiUPPP_CHLT3
    AccessioniPrimary (citable) accession number: B3QW96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3