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Protein

Dihydrolipoyl dehydrogenase

Gene

Ctha_2180

Organism
Chloroherpeton thalassium (strain ATCC 35110 / GB-78)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Catalytic activityi

Protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandFADUniRule annotation, Flavoprotein, NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Ordered Locus Names:Ctha_2180Imported
OrganismiChloroherpeton thalassium (strain ATCC 35110 / GB-78)Imported
Taxonomic identifieri517418 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChloroherpeton
Proteomesi
  • UP000001208 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi517418.Ctha_2180.

Structurei

3D structure databases

ProteinModelPortaliB3QVX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 338FAD/NAD-binding_domInterPro annotationAdd BLAST324
Domaini358 – 467Pyr_redox_dimInterPro annotationAdd BLAST110

Sequence similaritiesi

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiTMSEAVM.
OrthoDBiPOG091H0239.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 3 hits.
InterProiView protein in InterPro
IPR036188. FAD/NAD-bd_sf.
IPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer_sf.
IPR006258. Lipoamide_DH.
IPR001100. Pyr_nuc-diS_OxRdtase.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
PfamiView protein in Pfam
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
PIRSFiPIRSF000350. Mercury_reductase_MerA. 1 hit.
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiView protein in PROSITE
PS00076. PYRIDINE_REDOX_1. 1 hit.

Sequencei

Sequence statusi: Complete.

B3QVX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKESANKTP HEFDFDIAVI GSGPGGYECA IRASQLGYKT CIIEKEQTLG
60 70 80 90 100
GVCLNWGCIP TKSLLKNAEV IHTLKDAEEF GIKLNGFEID FTKVIRRSRK
110 120 130 140 150
VATKMAKGVE FLMKKNKIEV KKGYGKLKSA HEIEISYEKD GSSEVVSSQH
160 170 180 190 200
IILATGTKAR SIPSVPVDRE RIITSYEAMV LKEKPESLTV IGAGAIGMEF
210 220 230 240 250
AYFYNAVGTK VTVVELMPQI LPNEDEEIAT TLAKELKKQG IEILTDAQVQ
260 270 280 290 300
KAEAVENGVK TTVKLKDGSE KELQSDYALV AIGLTGNVEN LGLEEVGVET
310 320 330 340 350
ERGFIKVDEF GRTNVEGVYA IGDVAGGILL AHKASVEGIN CVEKIAGLSP
360 370 380 390 400
EPLDPMSIPA CTYCQPSVAH LGMTEKQALE KGYEIKVGKF PFMASGKATA
410 420 430 440 450
SGHNEGMVKL IFDKKYGELL GAHIIGYEAT EMIAELGMAK KLEATSEWIH
460 470
KTVHAHPTFS EAVKEAAAAA DGEAINI
Length:477
Mass (Da):51,544
Last modified:September 2, 2008 - v1
Checksum:iA475E655DE15DA14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001100 Genomic DNA. Translation: ACF14631.1.
RefSeqiWP_012500714.1. NC_011026.1.

Genome annotation databases

EnsemblBacteriaiACF14631; ACF14631; Ctha_2180.
KEGGicts:Ctha_2180.

Similar proteinsi

Entry informationi

Entry nameiB3QVX7_CHLT3
AccessioniPrimary (citable) accession number: B3QVX7
Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 22, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported