ID   B3QVV1_CHLT3            Unreviewed;       689 AA.
AC   B3QVV1;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 77.
DE   RecName: Full=Putative K(+)-stimulated pyrophosphate-energized sodium pump {ECO:0000256|HAMAP-Rule:MF_01129};
DE            EC=7.2.3.1 {ECO:0000256|HAMAP-Rule:MF_01129};
DE   AltName: Full=Membrane-bound sodium-translocating pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_01129};
DE   AltName: Full=Pyrophosphate-energized inorganic pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_01129};
DE            Short=Na(+)-PPase {ECO:0000256|HAMAP-Rule:MF_01129};
GN   Name=hppA {ECO:0000256|HAMAP-Rule:MF_01129};
GN   OrderedLocusNames=Ctha_0689 {ECO:0000313|EMBL:ACF13158.1};
OS   Chloroherpeton thalassium (strain ATCC 35110 / GB-78).
OC   Bacteria; Chlorobiota; Chlorobiia; Chlorobiales; Chloroherpetonaceae;
OC   Chloroherpeton.
OX   NCBI_TaxID=517418 {ECO:0000313|EMBL:ACF13158.1, ECO:0000313|Proteomes:UP000001208};
RN   [1] {ECO:0000313|EMBL:ACF13158.1, ECO:0000313|Proteomes:UP000001208}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35110 / GB-78 {ECO:0000313|Proteomes:UP000001208};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F., Overmann J.,
RA   Bryant D.A., Richardson P.;
RT   "Complete sequence of Chloroherpeton thalassium ATCC 35110.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sodium pump that utilizes the energy of pyrophosphate
CC       hydrolysis as the driving force for Na(+) movement across the membrane.
CC       {ECO:0000256|HAMAP-Rule:MF_01129}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=diphosphate + H2O + Na(+)(in) = H(+) + Na(+)(out) + 2
CC         phosphate; Xref=Rhea:RHEA:57884, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:43474; EC=7.2.3.1; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_01129};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_01129};
CC   -!- ACTIVITY REGULATION: Requires K(+) for maximal activity.
CC       {ECO:0000256|HAMAP-Rule:MF_01129}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01129}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_01129}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_01129}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass
CC       membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the H(+)-translocating pyrophosphatase
CC       (TC 3.A.10) family. K(+)-stimulated subfamily. {ECO:0000256|HAMAP-
CC       Rule:MF_01129}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|HAMAP-Rule:MF_01129}.
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DR   EMBL; CP001100; ACF13158.1; -; Genomic_DNA.
DR   RefSeq; WP_012499242.1; NC_011026.1.
DR   AlphaFoldDB; B3QVV1; -.
DR   KEGG; cts:Ctha_0689; -.
DR   eggNOG; COG3808; Bacteria.
DR   HOGENOM; CLU_008743_3_1_10; -.
DR   OrthoDB; 9808652at2; -.
DR   Proteomes; UP000001208; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009678; F:diphosphate hydrolysis-driven proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0004427; F:inorganic diphosphate phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030955; F:potassium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01129; PPase_energized_pump; 1.
DR   InterPro; IPR004131; PPase-energised_H-pump.
DR   NCBIfam; TIGR01104; V_PPase; 1.
DR   PANTHER; PTHR31998; K(+)-INSENSITIVE PYROPHOSPHATE-ENERGIZED PROTON PUMP; 1.
DR   PANTHER; PTHR31998:SF55; K(+)-STIMULATED PYROPHOSPHATE-ENERGIZED SODIUM PUMP; 1.
DR   Pfam; PF03030; H_PPase; 1.
DR   PIRSF; PIRSF001265; H+-PPase; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_01129};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_01129};
KW   Hydrolase {ECO:0000313|EMBL:ACF13158.1};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065, ECO:0000256|HAMAP-
KW   Rule:MF_01129};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|HAMAP-Rule:MF_01129};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01129};
KW   Potassium {ECO:0000256|HAMAP-Rule:MF_01129};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001208};
KW   Sodium {ECO:0000256|HAMAP-Rule:MF_01129};
KW   Sodium transport {ECO:0000256|HAMAP-Rule:MF_01129};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|HAMAP-
KW   Rule:MF_01129};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW   Rule:MF_01129};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW   Rule:MF_01129};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01129}.
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        57..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        81..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        126..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        163..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        239..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        269..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        301..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        340..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        369..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        399..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        479..499
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        511..533
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        578..596
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        602..625
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   SITE            473
FT                   /note="Determinant of potassium dependence"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
SQ   SEQUENCE   689 AA;  70969 MW;  62B677120D391198 CRC64;
     MDTLIYAIPA AGVISLLYAS LKTSWVTKQP TGTQEMTEIA GHIAEGAKAF LQREYRILII
     FVVAVAALLA FANMGRTDSS WLVAVSFVIG ALCSAGAGFI GMTVATKANV RTTHAARTGL
     AEALNVAFSG GLVMGLSVVG LGVLGLSVLF IVYSNLFDEV GRVINVISGF SLGASSIALF
     ARVGGGIYTK AADVGADLAG KVYEGIPEDD PRNPATIADN VGDNVGDVAG MGADLFESYV
     GSIIGTMVLG AAFVPVFQEM GVMPTAAVLL PLVLAGVGII VSILGSFFVK VKEGGNPQTA
     LNTGEFGASG VMAVLSYFII TMFLPEKWEL DGMTYTSQNI FFAVLIGLVS GVLIGIITEY
     YCSTHNKPVL GIAYQSVTGA ATNIIAGLGV GMFSTGFPII VLSIAIVASH YFAGLFGIAI
     AALGMLSVTG IQLAVDAYGP ISDNAGGIAE MSGMPPEVRE RTDTLDAVGN TTAAIGKGFA
     IGSAALTALA LFAAFMQQAN ISSIDISHPV IMAGLLIGAM LPFVFSAMAM GAVGRAARDM
     ITEVGRQFRE IKGLREGTAK AEYAKCVDIS TKAALREMIL PGLMGVFVPV IVGFTSKDML
     GGLLAGVTSS GVLMAIFQSN AGGAWDNAKK RIEGKLEIDG VMYGKGSDVH KAAVVGDTVG
     DPFKDTSGPS LNILMKLIAV VALVIAPLL
//