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Protein

Putative K(+)-stimulated pyrophosphate-energized sodium pump

Gene

hppA

Organism
Chloroherpeton thalassium (strain ATCC 35110 / GB-78)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na+ movement across the membrane.UniRule annotation

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Requires K+ for maximal activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei473Determinant of potassium dependenceUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processIon transport, Sodium transportUniRule annotation, Transport
LigandMagnesiumUniRule annotation, PotassiumUniRule annotation, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Putative K(+)-stimulated pyrophosphate-energized sodium pumpUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Membrane-bound sodium-translocating pyrophosphataseUniRule annotation
Pyrophosphate-energized inorganic pyrophosphataseUniRule annotation
Short name:
Na(+)-PPaseUniRule annotation
Gene namesi
Name:hppAUniRule annotation
Ordered Locus Names:Ctha_0689Imported
OrganismiChloroherpeton thalassium (strain ATCC 35110 / GB-78)Imported
Taxonomic identifieri517418 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChloroherpeton
Proteomesi
  • UP000001208 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalUniRule annotationAdd BLAST21
Transmembranei57 – 75HelicalUniRule annotationAdd BLAST19
Transmembranei81 – 105HelicalUniRule annotationAdd BLAST25
Transmembranei126 – 151HelicalUniRule annotationAdd BLAST26
Transmembranei163 – 181HelicalUniRule annotationAdd BLAST19
Transmembranei239 – 257HelicalUniRule annotationAdd BLAST19
Transmembranei269 – 289HelicalUniRule annotationAdd BLAST21
Transmembranei301 – 320HelicalUniRule annotationAdd BLAST20
Transmembranei340 – 362HelicalUniRule annotationAdd BLAST23
Transmembranei369 – 393HelicalUniRule annotationAdd BLAST25
Transmembranei399 – 423HelicalUniRule annotationAdd BLAST25
Transmembranei479 – 499HelicalUniRule annotationAdd BLAST21
Transmembranei511 – 533HelicalUniRule annotationAdd BLAST23
Transmembranei578 – 596HelicalUniRule annotationAdd BLAST19
Transmembranei602 – 625HelicalUniRule annotationAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi517418.Ctha_0689.

Family & Domainsi

Sequence similaritiesi

Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG4105EAY. Bacteria.
COG3808. LUCA.
HOGENOMiHOG000007098.
KOiK15987.
OMAiMATTAMQ.
OrthoDBiPOG091H0DQP.

Family and domain databases

HAMAPiMF_01129. PPase_energized_pump. 1 hit.
InterProiView protein in InterPro
IPR004131. PPase-energised_H-pump.
PANTHERiPTHR31998. PTHR31998. 1 hit.
PfamiView protein in Pfam
PF03030. H_PPase. 1 hit.
PIRSFiPIRSF001265. H+-PPase. 1 hit.
TIGRFAMsiTIGR01104. V_PPase. 1 hit.

Sequencei

Sequence statusi: Complete.

B3QVV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTLIYAIPA AGVISLLYAS LKTSWVTKQP TGTQEMTEIA GHIAEGAKAF
60 70 80 90 100
LQREYRILII FVVAVAALLA FANMGRTDSS WLVAVSFVIG ALCSAGAGFI
110 120 130 140 150
GMTVATKANV RTTHAARTGL AEALNVAFSG GLVMGLSVVG LGVLGLSVLF
160 170 180 190 200
IVYSNLFDEV GRVINVISGF SLGASSIALF ARVGGGIYTK AADVGADLAG
210 220 230 240 250
KVYEGIPEDD PRNPATIADN VGDNVGDVAG MGADLFESYV GSIIGTMVLG
260 270 280 290 300
AAFVPVFQEM GVMPTAAVLL PLVLAGVGII VSILGSFFVK VKEGGNPQTA
310 320 330 340 350
LNTGEFGASG VMAVLSYFII TMFLPEKWEL DGMTYTSQNI FFAVLIGLVS
360 370 380 390 400
GVLIGIITEY YCSTHNKPVL GIAYQSVTGA ATNIIAGLGV GMFSTGFPII
410 420 430 440 450
VLSIAIVASH YFAGLFGIAI AALGMLSVTG IQLAVDAYGP ISDNAGGIAE
460 470 480 490 500
MSGMPPEVRE RTDTLDAVGN TTAAIGKGFA IGSAALTALA LFAAFMQQAN
510 520 530 540 550
ISSIDISHPV IMAGLLIGAM LPFVFSAMAM GAVGRAARDM ITEVGRQFRE
560 570 580 590 600
IKGLREGTAK AEYAKCVDIS TKAALREMIL PGLMGVFVPV IVGFTSKDML
610 620 630 640 650
GGLLAGVTSS GVLMAIFQSN AGGAWDNAKK RIEGKLEIDG VMYGKGSDVH
660 670 680
KAAVVGDTVG DPFKDTSGPS LNILMKLIAV VALVIAPLL
Length:689
Mass (Da):70,969
Last modified:September 2, 2008 - v1
Checksum:i62B677120D391198
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001100 Genomic DNA. Translation: ACF13158.1.
RefSeqiWP_012499242.1. NC_011026.1.

Genome annotation databases

EnsemblBacteriaiACF13158; ACF13158; Ctha_0689.
KEGGicts:Ctha_0689.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiB3QVV1_CHLT3
AccessioniPrimary (citable) accession number: B3QVV1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: June 7, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported