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B3QVV1

- B3QVV1_CHLT3

UniProt

B3QVV1 - B3QVV1_CHLT3

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Protein

Putative K(+)-stimulated pyrophosphate-energized sodium pump

Gene

hppA

Organism
Chloroherpeton thalassium (strain ATCC 35110 / GB-78)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na+ movement across the membrane.UniRule annotation

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Note: Magnesium.UniRule annotation

Enzyme regulationi

Requires K+ for maximal activity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei473 – 4731Determinant of potassium dependenceUniRule annotation

GO - Molecular functioni

  1. hydrogen-translocating pyrophosphatase activity Source: UniProtKB-HAMAP
  2. inorganic diphosphatase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. potassium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. proton transport Source: InterPro
  2. sodium ion transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported

Keywords - Biological processi

Ion transport, Sodium transportUniRule annotation, Transport

Keywords - Ligandi

MagnesiumUniRule annotation, PotassiumUniRule annotation, Sodium

Enzyme and pathway databases

BioCyciCTHA517418:GHTO-693-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative K(+)-stimulated pyrophosphate-energized sodium pumpUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Membrane-bound sodium-translocating pyrophosphataseUniRule annotation
Pyrophosphate-energized inorganic pyrophosphataseUniRule annotation
Gene namesi
Name:hppAUniRule annotation
Ordered Locus Names:Ctha_0689Imported
OrganismiChloroherpeton thalassium (strain ATCC 35110 / GB-78)Imported
Taxonomic identifieri517418 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChloroherpeton
ProteomesiUP000001208: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalUniRule annotationAdd
BLAST
Transmembranei55 – 7521HelicalUniRule annotationAdd
BLAST
Transmembranei81 – 10121HelicalUniRule annotationAdd
BLAST
Transmembranei132 – 15221HelicalUniRule annotationAdd
BLAST
Transmembranei167 – 18721HelicalUniRule annotationAdd
BLAST
Transmembranei243 – 26321HelicalUniRule annotationAdd
BLAST
Transmembranei268 – 28821HelicalUniRule annotationAdd
BLAST
Transmembranei304 – 32421HelicalUniRule annotationAdd
BLAST
Transmembranei340 – 36021HelicalUniRule annotationAdd
BLAST
Transmembranei377 – 39721HelicalUniRule annotationAdd
BLAST
Transmembranei399 – 41921HelicalUniRule annotationAdd
BLAST
Transmembranei420 – 44021HelicalUniRule annotationAdd
BLAST
Transmembranei475 – 49521HelicalUniRule annotationAdd
BLAST
Transmembranei510 – 53021HelicalUniRule annotationAdd
BLAST
Transmembranei574 – 59421HelicalUniRule annotationAdd
BLAST
Transmembranei599 – 61921HelicalUniRule annotationAdd
BLAST
Transmembranei669 – 68921HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi517418.Ctha_0689.

Family & Domainsi

Sequence similaritiesi

Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiCOG3808.
HOGENOMiHOG000007098.
KOiK15987.
OMAiPVESIAY.
OrthoDBiEOG6TXQSF.

Family and domain databases

HAMAPiMF_01129. PPase_energized_pump.
InterProiIPR004131. PPase-energised_H-pump.
[Graphical view]
PfamiPF03030. H_PPase. 1 hit.
[Graphical view]
PIRSFiPIRSF001265. H+-PPase. 1 hit.
TIGRFAMsiTIGR01104. V_PPase. 1 hit.

Sequencei

Sequence statusi: Complete.

B3QVV1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTLIYAIPA AGVISLLYAS LKTSWVTKQP TGTQEMTEIA GHIAEGAKAF
60 70 80 90 100
LQREYRILII FVVAVAALLA FANMGRTDSS WLVAVSFVIG ALCSAGAGFI
110 120 130 140 150
GMTVATKANV RTTHAARTGL AEALNVAFSG GLVMGLSVVG LGVLGLSVLF
160 170 180 190 200
IVYSNLFDEV GRVINVISGF SLGASSIALF ARVGGGIYTK AADVGADLAG
210 220 230 240 250
KVYEGIPEDD PRNPATIADN VGDNVGDVAG MGADLFESYV GSIIGTMVLG
260 270 280 290 300
AAFVPVFQEM GVMPTAAVLL PLVLAGVGII VSILGSFFVK VKEGGNPQTA
310 320 330 340 350
LNTGEFGASG VMAVLSYFII TMFLPEKWEL DGMTYTSQNI FFAVLIGLVS
360 370 380 390 400
GVLIGIITEY YCSTHNKPVL GIAYQSVTGA ATNIIAGLGV GMFSTGFPII
410 420 430 440 450
VLSIAIVASH YFAGLFGIAI AALGMLSVTG IQLAVDAYGP ISDNAGGIAE
460 470 480 490 500
MSGMPPEVRE RTDTLDAVGN TTAAIGKGFA IGSAALTALA LFAAFMQQAN
510 520 530 540 550
ISSIDISHPV IMAGLLIGAM LPFVFSAMAM GAVGRAARDM ITEVGRQFRE
560 570 580 590 600
IKGLREGTAK AEYAKCVDIS TKAALREMIL PGLMGVFVPV IVGFTSKDML
610 620 630 640 650
GGLLAGVTSS GVLMAIFQSN AGGAWDNAKK RIEGKLEIDG VMYGKGSDVH
660 670 680
KAAVVGDTVG DPFKDTSGPS LNILMKLIAV VALVIAPLL
Length:689
Mass (Da):70,969
Last modified:September 2, 2008 - v1
Checksum:i62B677120D391198
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001100 Genomic DNA. Translation: ACF13158.1.
RefSeqiWP_012499242.1. NC_011026.1.
YP_001995605.1. NC_011026.1.

Genome annotation databases

EnsemblBacteriaiACF13158; ACF13158; Ctha_0689.
GeneIDi6421734.
KEGGicts:Ctha_0689.
PATRICi21429959. VBIChlTha99257_0807.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001100 Genomic DNA. Translation: ACF13158.1 .
RefSeqi WP_012499242.1. NC_011026.1.
YP_001995605.1. NC_011026.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 517418.Ctha_0689.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF13158 ; ACF13158 ; Ctha_0689 .
GeneIDi 6421734.
KEGGi cts:Ctha_0689.
PATRICi 21429959. VBIChlTha99257_0807.

Phylogenomic databases

eggNOGi COG3808.
HOGENOMi HOG000007098.
KOi K15987.
OMAi PVESIAY.
OrthoDBi EOG6TXQSF.

Enzyme and pathway databases

BioCyci CTHA517418:GHTO-693-MONOMER.

Family and domain databases

HAMAPi MF_01129. PPase_energized_pump.
InterProi IPR004131. PPase-energised_H-pump.
[Graphical view ]
Pfami PF03030. H_PPase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001265. H+-PPase. 1 hit.
TIGRFAMsi TIGR01104. V_PPase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Chloroherpeton thalassium ATCC 35110."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F.
    , Overmann J., Bryant D.A., Richardson P.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35110 / GB-78Imported.

Entry informationi

Entry nameiB3QVV1_CHLT3
AccessioniPrimary (citable) accession number: B3QVV1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 26, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3