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B3QVV1

- B3QVV1_CHLT3

UniProt

B3QVV1 - B3QVV1_CHLT3

Protein

Putative K(+)-stimulated pyrophosphate-energized sodium pump

Gene

hppA

Organism
Chloroherpeton thalassium (strain ATCC 35110 / GB-78)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na+ movement across the membrane.UniRule annotation

    Catalytic activityi

    Diphosphate + H2O = 2 phosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Enzyme regulationi

    Requires K+ for maximal activity.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei473 – 4731Determinant of potassium dependenceUniRule annotation

    GO - Molecular functioni

    1. hydrogen-translocating pyrophosphatase activity Source: UniProtKB-HAMAP
    2. inorganic diphosphatase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. potassium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. proton transport Source: InterPro
    2. sodium ion transport Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotationImported

    Keywords - Biological processi

    Ion transport, Sodium transportUniRule annotation, Transport

    Keywords - Ligandi

    MagnesiumUniRule annotation, PotassiumUniRule annotation, Sodium

    Enzyme and pathway databases

    BioCyciCTHA517418:GHTO-693-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative K(+)-stimulated pyrophosphate-energized sodium pumpUniRule annotation (EC:3.6.1.1UniRule annotation)
    Alternative name(s):
    Membrane-bound sodium-translocating pyrophosphataseUniRule annotation
    Pyrophosphate-energized inorganic pyrophosphataseUniRule annotation
    Gene namesi
    Name:hppAUniRule annotation
    Ordered Locus Names:Ctha_0689Imported
    OrganismiChloroherpeton thalassium (strain ATCC 35110 / GB-78)Imported
    Taxonomic identifieri517418 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChloroherpeton
    ProteomesiUP000001208: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cell membraneUniRule annotation, Membrane

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi517418.Ctha_0689.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121Helical;UniRule annotationAdd
    BLAST
    Transmembranei55 – 7521Helical;UniRule annotationAdd
    BLAST
    Transmembranei81 – 10121Helical;UniRule annotationAdd
    BLAST
    Transmembranei132 – 15221Helical;UniRule annotationAdd
    BLAST
    Transmembranei167 – 18721Helical;UniRule annotationAdd
    BLAST
    Transmembranei243 – 26321Helical;UniRule annotationAdd
    BLAST
    Transmembranei268 – 28821Helical;UniRule annotationAdd
    BLAST
    Transmembranei304 – 32421Helical;UniRule annotationAdd
    BLAST
    Transmembranei340 – 36021Helical;UniRule annotationAdd
    BLAST
    Transmembranei377 – 39721Helical;UniRule annotationAdd
    BLAST
    Transmembranei399 – 41921Helical;UniRule annotationAdd
    BLAST
    Transmembranei420 – 44021Helical;UniRule annotationAdd
    BLAST
    Transmembranei475 – 49521Helical;UniRule annotationAdd
    BLAST
    Transmembranei510 – 53021Helical;UniRule annotationAdd
    BLAST
    Transmembranei574 – 59421Helical;UniRule annotationAdd
    BLAST
    Transmembranei599 – 61921Helical;UniRule annotationAdd
    BLAST
    Transmembranei669 – 68921Helical;UniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily. [View classification]UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotation

    Phylogenomic databases

    eggNOGiCOG3808.
    HOGENOMiHOG000007098.
    KOiK15987.
    OMAiPVESIAY.
    OrthoDBiEOG6TXQSF.

    Family and domain databases

    HAMAPiMF_01129. PPase_energized_pump.
    InterProiIPR004131. PPase-energised_H-pump.
    [Graphical view]
    PfamiPF03030. H_PPase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001265. H+-PPase. 1 hit.
    TIGRFAMsiTIGR01104. V_PPase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B3QVV1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTLIYAIPA AGVISLLYAS LKTSWVTKQP TGTQEMTEIA GHIAEGAKAF    50
    LQREYRILII FVVAVAALLA FANMGRTDSS WLVAVSFVIG ALCSAGAGFI 100
    GMTVATKANV RTTHAARTGL AEALNVAFSG GLVMGLSVVG LGVLGLSVLF 150
    IVYSNLFDEV GRVINVISGF SLGASSIALF ARVGGGIYTK AADVGADLAG 200
    KVYEGIPEDD PRNPATIADN VGDNVGDVAG MGADLFESYV GSIIGTMVLG 250
    AAFVPVFQEM GVMPTAAVLL PLVLAGVGII VSILGSFFVK VKEGGNPQTA 300
    LNTGEFGASG VMAVLSYFII TMFLPEKWEL DGMTYTSQNI FFAVLIGLVS 350
    GVLIGIITEY YCSTHNKPVL GIAYQSVTGA ATNIIAGLGV GMFSTGFPII 400
    VLSIAIVASH YFAGLFGIAI AALGMLSVTG IQLAVDAYGP ISDNAGGIAE 450
    MSGMPPEVRE RTDTLDAVGN TTAAIGKGFA IGSAALTALA LFAAFMQQAN 500
    ISSIDISHPV IMAGLLIGAM LPFVFSAMAM GAVGRAARDM ITEVGRQFRE 550
    IKGLREGTAK AEYAKCVDIS TKAALREMIL PGLMGVFVPV IVGFTSKDML 600
    GGLLAGVTSS GVLMAIFQSN AGGAWDNAKK RIEGKLEIDG VMYGKGSDVH 650
    KAAVVGDTVG DPFKDTSGPS LNILMKLIAV VALVIAPLL 689
    Length:689
    Mass (Da):70,969
    Last modified:September 2, 2008 - v1
    Checksum:i62B677120D391198
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001100 Genomic DNA. Translation: ACF13158.1.
    RefSeqiYP_001995605.1. NC_011026.1.

    Genome annotation databases

    EnsemblBacteriaiACF13158; ACF13158; Ctha_0689.
    GeneIDi6421734.
    KEGGicts:Ctha_0689.
    PATRICi21429959. VBIChlTha99257_0807.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001100 Genomic DNA. Translation: ACF13158.1 .
    RefSeqi YP_001995605.1. NC_011026.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 517418.Ctha_0689.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF13158 ; ACF13158 ; Ctha_0689 .
    GeneIDi 6421734.
    KEGGi cts:Ctha_0689.
    PATRICi 21429959. VBIChlTha99257_0807.

    Phylogenomic databases

    eggNOGi COG3808.
    HOGENOMi HOG000007098.
    KOi K15987.
    OMAi PVESIAY.
    OrthoDBi EOG6TXQSF.

    Enzyme and pathway databases

    BioCyci CTHA517418:GHTO-693-MONOMER.

    Family and domain databases

    HAMAPi MF_01129. PPase_energized_pump.
    InterProi IPR004131. PPase-energised_H-pump.
    [Graphical view ]
    Pfami PF03030. H_PPase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001265. H+-PPase. 1 hit.
    TIGRFAMsi TIGR01104. V_PPase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Chloroherpeton thalassium ATCC 35110."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F.
      , Overmann J., Bryant D.A., Richardson P.
      Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35110 / GB-78Imported.

    Entry informationi

    Entry nameiB3QVV1_CHLT3
    AccessioniPrimary (citable) accession number: B3QVV1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 2, 2008
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3