B3QV24 (GCST_CHLT3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	Ctha_0507

Organism

Chloroherpeton thalassium (strain ATCC 35110 / GB-78) [Complete proteome] [HAMAP]

Taxonomic identifier

517418 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chloroherpeton

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Aminomethyltransferase HAMAP MF_00259		PRO_1000114088

Sequences

	Sequence		Length	Mass (Da)
	B3QV24 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: 62ECF06EEF770330	FASTA	362	40,179
	10 20 30 40 50 60 MKYTPLHKIH QQLGAKLVDF AGFEMPVQYD GILVEHKAVR EAVGLFDVSH MGEFEVKGKG 70 80 90 100 110 120 AKAFLQNMTT NDVESLCDGK AQYSLLLYED GGVVDDLLVY KIADEHYFLI VNASNIEKDF 130 140 150 160 170 180 DWLKQHQPDD EVVLENRSDE LSLIAIQGPK AEAVLSKLTD VPLDAIKYYH FVFGDVCGKR 190 200 210 220 230 240 TLISRTGYTG EAGFELCMAN EHAEEIWHAL IEAGLPFGIV PVGLGARDTL RLEMGYSLYG 250 260 270 280 290 300 HEIDHQTNPY EAQLGWITKL QKGDFIGKNA CVEKKLHLEQ TLVGFTLTGK NIPRQGYKIQ 310 320 330 340 350 360 DLSGTDIGVV CSGTLSPTLG KPIGTGYVKS SFSKIDSKVY INIRGKLQEA AVVKVPFLHK NR

References

[1]

"Complete sequence of Chloroherpeton thalassium ATCC 35110." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F. , Overmann J., Bryant D.A., Richardson P. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35110 / GB-78.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001100 Genomic DNA. Translation: ACF12978.1.
RefSeq	YP_001995425.1. NC_011026.1.
3D structure databases
ProteinModelPortal	B3QV24.
ModBase	Search...
Protein-protein interaction databases
STRING	B3QV24.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6421551.
GenomeReviews	Gene locus Ctha_0507 in contig CP001100_GR.
KEGG	cts:Ctha_0507.
PATRIC	21429527. VBIChlTha99257_0592.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG299834.
OMA	KALYGGM.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_CHLT3

Accession

Primary (citable) accession number: B3QV24

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 2, 2008
Last modified:	January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program