Reviewed, UniProtKB/Swiss-Prot B3QUX5 (NUOA1_CHLT3)

Names and origin

Protein names

Recommended name:
    NADH-quinone oxidoreductase subunit A 1
    EC=1.6.99.5
Alternative name(s):
    NADH dehydrogenase I subunit A 1
    NDH-1 subunit A 1
    NUO1 1

Gene names

Name:	nuoA1
Ordered Locus Names:	Ctha_2024

Organism

Chloroherpeton thalassium (strain ATCC 35110 / GB-78) [Complete proteome] [HAMAP]

Taxonomic identifier

517418 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chloroherpeton

Protein attributes

Sequence length	121 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP MF_01394
Catalytic activity	NADH + quinone = NAD+ + quinol. HAMAP MF_01394
Subunit structure	NDH-1 is composed of 14 different subunits. Subunits nuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity. HAMAP MF_01394
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01394.
Sequence similarities	Belongs to the complex I subunit 3 family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: HAMAP photosynthesis, light reaction Inferred from electronic annotation. Source: HAMAP transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 121	121	NADH-quinone oxidoreductase subunit A 1 HAMAP MF_01394		PRO_0000362661
Regions
	Transmembrane	6 – 26	21	Potential
	Transmembrane	62 – 82	21	Potential
	Transmembrane	90 – 110	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	B3QUX5-1 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: 38F1C46550B1EEF0	FASTA	121	13,897
	10 20 30 40 50 60 MLESYFPIFV VISIAIILAV VLLSIGKIIG PKRNNPEKLT PYESGMDPVG STRTRVTVRF 70 80 90 100 110 120 YLVAMIFIVF DIEVIFMYPW AVSFRELSGF YGLIPMVTFV LILLAGYYYI LKKKALDWDE E

References

[1]

"Complete sequence of Chloroherpeton thalassium ATCC 35110." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F. , Overmann J., Bryant D.A., Richardson P. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001100 Genomic DNA. Translation: ACF14476.1.
RefSeq	YP_001996923.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6423104.
GenomeReviews	Gene locus Ctha_2024 in contig CP001100_GR.
KEGG	cts:Ctha_2024.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG605540.
OMA	VAREIWG.
Family and domain databases
HAMAP	MF_01394. NDH1_NuoA. [Tree]
InterPro	IPR000440. NADH_UbQ/plastoQ_OxRdtase_su3. [Graphical view]
PANTHER	PTHR11058. Oxidored_q4. 1 hit.
Pfam	PF00507. Oxidored_q4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUOA1_CHLT3

Accession

Primary (citable) accession number: B3QUX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	September 2, 2008
Last modified:	January 19, 2010
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)