Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B3QUT6 (GCSPA_CHLT3) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Ctha_1983
OrganismChloroherpeton thalassium (strain ATCC 35110 / GB-78) [Complete proteome] [HAMAP]
Taxonomic identifier517418 [NCBI]
Taxonomic lineageBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChloroherpeton

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 443443Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000132475

Sequences

Sequence LengthMass (Da)Tools
B3QUT6 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: D0FC1724971D35F2

FASTA44347,955
        10         20         30         40         50         60 
MPFIPNTDAD RATMLQAVGA STFDDLISNI PEKVRFKGAL NLPEALSEME VLEELNALAN 

        70         80         90        100        110        120 
ANQDTQKVTS FLGGGAYDHF VPSAIGAIIS RSEFYTAYTP YQAEVSQGTL QAMYEFQTMV 

       130        140        150        160        170        180 
ARLTGMDVAN ASMYDGATAL AEAMLLSVAH KNRKEVVLAG KINPNAVAIM QTYGHGQEIH 

       190        200        210        220        230        240 
IRQSALENGG ADLASVRELV SDKTAAMIVQ HPNFFGCLED VHELQKIAAE NNALFIVSAD 

       250        260        270        280        290        300 
PISLGILEAP GNYGADIVVG EGQGLGNTQS FGGPYLGLFA AKSQLLRKIP GRLSGMTVDK 

       310        320        330        340        350        360 
DGNQGFILTL QTREQHIRRE KATSNICTNQ ALNALCACIY MSMMGKEGLT QVASLSIQKA 

       370        380        390        400        410        420 
HYLANEIQKL DGFKLKFSRP FFKEFAIELP IPASQAIAKL LEKKIHAGVD LKMAEENGLL 

       430        440 
IAVTEKRSKA EMNSFVEALK ELC 

« Hide

References

[1]"Complete sequence of Chloroherpeton thalassium ATCC 35110."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F. expand/collapse author list , Overmann J., Bryant D.A., Richardson P.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35110 / GB-78.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001100 Genomic DNA. Translation: ACF14437.1.
RefSeqYP_001996884.1. NC_011026.1.

3D structure databases

ProteinModelPortalB3QUT6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING517418.Ctha_1983.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACF14437; ACF14437; Ctha_1983.
GeneID6423063.
KEGGcts:Ctha_1983.
PATRIC21433053. VBIChlTha99257_2319.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMASMYDGST.
OrthoDBEOG6XWV3B.
ProtClustDBPRK00451.

Enzyme and pathway databases

BioCycCTHA517418:GHTO-2023-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_CHLT3
AccessionPrimary (citable) accession number: B3QUT6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: February 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families