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B3QUT6

- GCSPA_CHLT3

UniProt

B3QUT6 - GCSPA_CHLT3

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Chloroherpeton thalassium (strain ATCC 35110 / GB-78)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciCTHA517418:GHTO-2023-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Ctha_1983
OrganismiChloroherpeton thalassium (strain ATCC 35110 / GB-78)
Taxonomic identifieri517418 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChloroherpeton
ProteomesiUP000001208: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000132475Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi517418.Ctha_1983.

Structurei

3D structure databases

ProteinModelPortaliB3QUT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiYVRKIPG.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B3QUT6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPFIPNTDAD RATMLQAVGA STFDDLISNI PEKVRFKGAL NLPEALSEME
60 70 80 90 100
VLEELNALAN ANQDTQKVTS FLGGGAYDHF VPSAIGAIIS RSEFYTAYTP
110 120 130 140 150
YQAEVSQGTL QAMYEFQTMV ARLTGMDVAN ASMYDGATAL AEAMLLSVAH
160 170 180 190 200
KNRKEVVLAG KINPNAVAIM QTYGHGQEIH IRQSALENGG ADLASVRELV
210 220 230 240 250
SDKTAAMIVQ HPNFFGCLED VHELQKIAAE NNALFIVSAD PISLGILEAP
260 270 280 290 300
GNYGADIVVG EGQGLGNTQS FGGPYLGLFA AKSQLLRKIP GRLSGMTVDK
310 320 330 340 350
DGNQGFILTL QTREQHIRRE KATSNICTNQ ALNALCACIY MSMMGKEGLT
360 370 380 390 400
QVASLSIQKA HYLANEIQKL DGFKLKFSRP FFKEFAIELP IPASQAIAKL
410 420 430 440
LEKKIHAGVD LKMAEENGLL IAVTEKRSKA EMNSFVEALK ELC
Length:443
Mass (Da):47,955
Last modified:September 2, 2008 - v1
Checksum:iD0FC1724971D35F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001100 Genomic DNA. Translation: ACF14437.1.
RefSeqiYP_001996884.1. NC_011026.1.

Genome annotation databases

EnsemblBacteriaiACF14437; ACF14437; Ctha_1983.
GeneIDi6423063.
KEGGicts:Ctha_1983.
PATRICi21433053. VBIChlTha99257_2319.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001100 Genomic DNA. Translation: ACF14437.1 .
RefSeqi YP_001996884.1. NC_011026.1.

3D structure databases

ProteinModelPortali B3QUT6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 517418.Ctha_1983.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF14437 ; ACF14437 ; Ctha_1983 .
GeneIDi 6423063.
KEGGi cts:Ctha_1983.
PATRICi 21433053. VBIChlTha99257_2319.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi YVRKIPG.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci CTHA517418:GHTO-2023-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Chloroherpeton thalassium ATCC 35110."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F.
    , Overmann J., Bryant D.A., Richardson P.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35110 / GB-78.

Entry informationi

Entry nameiGCSPA_CHLT3
AccessioniPrimary (citable) accession number: B3QUT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3