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B3QT42 (THIM_CHLT3) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:Ctha_1684
OrganismChloroherpeton thalassium (strain ATCC 35110 / GB-78) [Complete proteome] [HAMAP]
Taxonomic identifier517418 [NCBI]
Taxonomic lineageBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChloroherpeton

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383834

Sites

Binding site471Substrate; via amide nitrogen By similarity
Binding site1231ATP By similarity
Binding site1691ATP By similarity
Binding site1961Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
B3QT42 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: AC08DA1BECB98F57

FASTA26728,135
        10         20         30         40         50         60 
MEINATTLWR DILAVRTKAP LVHNITNYVV MNSTANALLS IGASPVMAHA EEEVIDMVTI 

        70         80         90        100        110        120 
AGSLVINIGT LSKAWVAAMH KAMKKAHELQ KPIVFDPVGA GATPYRTQTI LELIHETPPS 

       130        140        150        160        170        180 
IIRGNSSEIK ALVEAGIKTK GVDSTESSES AIEAAKHLSQ KYGAVICISG ATDHILNQEE 

       190        200        210        220        230        240 
YVRVENGHPM MTKVTGLGCT ATAVVAAFAA INPSMMEATA HGMAAMGIAG EIAAKNVAGP 

       250        260 
GSLQVNFLDT LYSLSEADVH SHLKICA 

« Hide

References

[1]"Complete sequence of Chloroherpeton thalassium ATCC 35110."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F. expand/collapse author list , Overmann J., Bryant D.A., Richardson P.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35110 / GB-78.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001100 Genomic DNA. Translation: ACF14141.1.
RefSeqYP_001996588.1. NC_011026.1.

3D structure databases

ProteinModelPortalB3QT42.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING517418.Ctha_1684.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACF14141; ACF14141; Ctha_1684.
GeneID6422761.
KEGGcts:Ctha_1684.
PATRIC21432351. VBIChlTha99257_1972.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMAIMALANM.
OrthoDBEOG628F8M.

Enzyme and pathway databases

BioCycCTHA517418:GHTO-1721-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_CHLT3
AccessionPrimary (citable) accession number: B3QT42
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 2, 2008
Last modified: June 11, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways