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B3QS77

- GCSPB_CHLT3

UniProt

B3QS77 - GCSPB_CHLT3

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Chloroherpeton thalassium (strain ATCC 35110 / GB-78)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCTHA517418:GHTO-1596-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Ctha_1563
OrganismiChloroherpeton thalassium (strain ATCC 35110 / GB-78)
Taxonomic identifieri517418 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChloroherpeton
ProteomesiUP000001208: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000132497Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei269 – 2691N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi517418.Ctha_1563.

Structurei

3D structure databases

ProteinModelPortaliB3QS77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiIFERRIK.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B3QS77-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEPLIFEKS KSGRKGYTLP KCDVPVQEVS ELIPAQFLRK AKADLPEVQE
60 70 80 90 100
NEVVRHFVKL STLNHHVDKG MYPLGSCTMK YNPKVNEVTS ALPGFSALHP
110 120 130 140 150
LQPQESVQGA LKLMYELQEW LKEICGMKAV SLQPVAGAHG ELTGILLIRK
160 170 180 190 200
YHEKQGKPRK KILVPDSAHG TNPASSAIAG YMTVGVKTNA RGLTDMDDLR
210 220 230 240 250
AKLDEDVAAL MLTNPNTLGI FESQILEISE LLHANGSLLY MDGANMNALL
260 270 280 290 300
GITRPGDMGF DVVHYNLHKT FSTPHGGGGP GSGPVGVSEK LVEFLPTPAI
310 320 330 340 350
EKKESGEKTS YCLNYDLPDS IGKMSGFYGN FSIMVRAYTY LLMHGAKGLR
360 370 380 390 400
AVSENAIINA TYLLSRLRGK FDVPYDEQIM HEFCLSGERQ KTNGVKTLDM
410 420 430 440 450
AKRLLDFGFH APTIYFPLIV KECMMIEPTE SETKETLDDF ADVMLRIAEE
460 470 480 490
AESNPEMVLN APHNTPVKRL DDAYASRNIN IKYTPKEKET VEA
Length:493
Mass (Da):54,523
Last modified:September 2, 2008 - v1
Checksum:i5AE8E609D84CA1D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001100 Genomic DNA. Translation: ACF14022.1.
RefSeqiWP_012500106.1. NC_011026.1.
YP_001996469.1. NC_011026.1.

Genome annotation databases

EnsemblBacteriaiACF14022; ACF14022; Ctha_1563.
GeneIDi6422636.
KEGGicts:Ctha_1563.
PATRICi21432061. VBIChlTha99257_1831.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001100 Genomic DNA. Translation: ACF14022.1 .
RefSeqi WP_012500106.1. NC_011026.1.
YP_001996469.1. NC_011026.1.

3D structure databases

ProteinModelPortali B3QS77.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 517418.Ctha_1563.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF14022 ; ACF14022 ; Ctha_1563 .
GeneIDi 6422636.
KEGGi cts:Ctha_1563.
PATRICi 21432061. VBIChlTha99257_1831.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi IFERRIK.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci CTHA517418:GHTO-1596-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Chloroherpeton thalassium ATCC 35110."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F.
    , Overmann J., Bryant D.A., Richardson P.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35110 / GB-78.

Entry informationi

Entry nameiGCSPB_CHLT3
AccessioniPrimary (citable) accession number: B3QS77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: October 1, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3