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B3QS77

- GCSPB_CHLT3

UniProt

B3QS77 - GCSPB_CHLT3

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 2
Gene
gcvPB, Ctha_1563
Organism
Chloroherpeton thalassium (strain ATCC 35110 / GB-78)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCTHA517418:GHTO-1596-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:Ctha_1563
OrganismiChloroherpeton thalassium (strain ATCC 35110 / GB-78)
Taxonomic identifieri517418 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChloroherpeton
ProteomesiUP000001208: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation
PRO_1000132497Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei269 – 2691N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi517418.Ctha_1563.

Structurei

3D structure databases

ProteinModelPortaliB3QS77.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiIFERRIK.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B3QS77-1 [UniParc]FASTAAdd to Basket

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MTEPLIFEKS KSGRKGYTLP KCDVPVQEVS ELIPAQFLRK AKADLPEVQE    50
NEVVRHFVKL STLNHHVDKG MYPLGSCTMK YNPKVNEVTS ALPGFSALHP 100
LQPQESVQGA LKLMYELQEW LKEICGMKAV SLQPVAGAHG ELTGILLIRK 150
YHEKQGKPRK KILVPDSAHG TNPASSAIAG YMTVGVKTNA RGLTDMDDLR 200
AKLDEDVAAL MLTNPNTLGI FESQILEISE LLHANGSLLY MDGANMNALL 250
GITRPGDMGF DVVHYNLHKT FSTPHGGGGP GSGPVGVSEK LVEFLPTPAI 300
EKKESGEKTS YCLNYDLPDS IGKMSGFYGN FSIMVRAYTY LLMHGAKGLR 350
AVSENAIINA TYLLSRLRGK FDVPYDEQIM HEFCLSGERQ KTNGVKTLDM 400
AKRLLDFGFH APTIYFPLIV KECMMIEPTE SETKETLDDF ADVMLRIAEE 450
AESNPEMVLN APHNTPVKRL DDAYASRNIN IKYTPKEKET VEA 493
Length:493
Mass (Da):54,523
Last modified:September 2, 2008 - v1
Checksum:i5AE8E609D84CA1D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001100 Genomic DNA. Translation: ACF14022.1.
RefSeqiWP_012500106.1. NC_011026.1.
YP_001996469.1. NC_011026.1.

Genome annotation databases

EnsemblBacteriaiACF14022; ACF14022; Ctha_1563.
GeneIDi6422636.
KEGGicts:Ctha_1563.
PATRICi21432061. VBIChlTha99257_1831.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001100 Genomic DNA. Translation: ACF14022.1 .
RefSeqi WP_012500106.1. NC_011026.1.
YP_001996469.1. NC_011026.1.

3D structure databases

ProteinModelPortali B3QS77.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 517418.Ctha_1563.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF14022 ; ACF14022 ; Ctha_1563 .
GeneIDi 6422636.
KEGGi cts:Ctha_1563.
PATRICi 21432061. VBIChlTha99257_1831.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi IFERRIK.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci CTHA517418:GHTO-1596-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Chloroherpeton thalassium ATCC 35110."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F.
    , Overmann J., Bryant D.A., Richardson P.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35110 / GB-78.

Entry informationi

Entry nameiGCSPB_CHLT3
AccessioniPrimary (citable) accession number: B3QS77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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