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B3QS77

- GCSPB_CHLT3

UniProt

B3QS77 - GCSPB_CHLT3

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Chloroherpeton thalassium (strain ATCC 35110 / GB-78)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciCTHA517418:GHTO-1596-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 2UniRule annotation
    Glycine decarboxylase subunit 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
    Gene namesi
    Name:gcvPBUniRule annotation
    Ordered Locus Names:Ctha_1563
    OrganismiChloroherpeton thalassium (strain ATCC 35110 / GB-78)
    Taxonomic identifieri517418 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChloroherpeton
    ProteomesiUP000001208: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 493493Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000132497Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei269 – 2691N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi517418.Ctha_1563.

    Structurei

    3D structure databases

    ProteinModelPortaliB3QS77.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239368.
    KOiK00283.
    OMAiIFERRIK.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00713. GcvPB.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B3QS77-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEPLIFEKS KSGRKGYTLP KCDVPVQEVS ELIPAQFLRK AKADLPEVQE    50
    NEVVRHFVKL STLNHHVDKG MYPLGSCTMK YNPKVNEVTS ALPGFSALHP 100
    LQPQESVQGA LKLMYELQEW LKEICGMKAV SLQPVAGAHG ELTGILLIRK 150
    YHEKQGKPRK KILVPDSAHG TNPASSAIAG YMTVGVKTNA RGLTDMDDLR 200
    AKLDEDVAAL MLTNPNTLGI FESQILEISE LLHANGSLLY MDGANMNALL 250
    GITRPGDMGF DVVHYNLHKT FSTPHGGGGP GSGPVGVSEK LVEFLPTPAI 300
    EKKESGEKTS YCLNYDLPDS IGKMSGFYGN FSIMVRAYTY LLMHGAKGLR 350
    AVSENAIINA TYLLSRLRGK FDVPYDEQIM HEFCLSGERQ KTNGVKTLDM 400
    AKRLLDFGFH APTIYFPLIV KECMMIEPTE SETKETLDDF ADVMLRIAEE 450
    AESNPEMVLN APHNTPVKRL DDAYASRNIN IKYTPKEKET VEA 493
    Length:493
    Mass (Da):54,523
    Last modified:September 2, 2008 - v1
    Checksum:i5AE8E609D84CA1D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001100 Genomic DNA. Translation: ACF14022.1.
    RefSeqiWP_012500106.1. NC_011026.1.
    YP_001996469.1. NC_011026.1.

    Genome annotation databases

    EnsemblBacteriaiACF14022; ACF14022; Ctha_1563.
    GeneIDi6422636.
    KEGGicts:Ctha_1563.
    PATRICi21432061. VBIChlTha99257_1831.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001100 Genomic DNA. Translation: ACF14022.1 .
    RefSeqi WP_012500106.1. NC_011026.1.
    YP_001996469.1. NC_011026.1.

    3D structure databases

    ProteinModelPortali B3QS77.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 517418.Ctha_1563.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF14022 ; ACF14022 ; Ctha_1563 .
    GeneIDi 6422636.
    KEGGi cts:Ctha_1563.
    PATRICi 21432061. VBIChlTha99257_1831.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239368.
    KOi K00283.
    OMAi IFERRIK.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci CTHA517418:GHTO-1596-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00713. GcvPB.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Chloroherpeton thalassium ATCC 35110."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F.
      , Overmann J., Bryant D.A., Richardson P.
      Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35110 / GB-78.

    Entry informationi

    Entry nameiGCSPB_CHLT3
    AccessioniPrimary (citable) accession number: B3QS77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3