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B3QS62

- PUR9_CHLT3

UniProt

B3QS62 - PUR9_CHLT3

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Chloroherpeton thalassium (strain ATCC 35110 / GB-78)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciCTHA517418:GHTO-1581-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:Ctha_1548
    OrganismiChloroherpeton thalassium (strain ATCC 35110 / GB-78)
    Taxonomic identifieri517418 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChloroherpeton
    ProteomesiUP000001208: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 525525Bifunctional purine biosynthesis protein PurHPRO_1000096052Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi517418.Ctha_1548.

    Structurei

    3D structure databases

    ProteinModelPortaliB3QS62.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230372.
    KOiK00602.
    OMAiDEIACCA.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B3QS62-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAERKIKRAL ISVSDKTGII DFAKSLAEFG VEIFSTGGTL KKLIEAGIAA    50
    KSISEITKFP EIMDGRVKTL HPAIHGGLLA VRGNSDHEKQ AAENNINFID 100
    LVAVNLYPFE ATVAKPDVTF ADAIENIDIG GPSMLRSAAK NHKSVTVITD 150
    AADYQCVLEE MRANDGATTE ATRLYLAKKV FALTARYDGA ISNYLEKISQ 200
    TDESVLPNHL SVSLTKEIDM RYGENPHQKA GFYAMKVGEQ NLSFDEFFEK 250
    LHGKSLSYNN LLDISAAAGL IEEFRGAEPT VAIFKHTNPC GVAQADSLET 300
    AYRKAFSTDT QAPFGGIIAV NRPLDMATAK AINEIFTEIV IAPEFEEGVL 350
    EYLMKKKDRR LIRQLKALPS SALEFRSTVC GLLVQDKDAK TATKEELKVV 400
    TKRQPTEAEL EDLLFAWKIC KHVKSNTIVY AKDMQTVGVG AGQMSRVDSS 450
    RIARWKAGEV NLELKNSVVA SDAFFPFADG LIAAAEAGAS AVIQPGGSIR 500
    DEEVIAAADE RNIAMVFTGT RHFRH 525
    Length:525
    Mass (Da):57,327
    Last modified:September 2, 2008 - v1
    Checksum:iCC8EDE53887E6724
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001100 Genomic DNA. Translation: ACF14007.1.
    RefSeqiWP_012500091.1. NC_011026.1.
    YP_001996454.1. NC_011026.1.

    Genome annotation databases

    EnsemblBacteriaiACF14007; ACF14007; Ctha_1548.
    GeneIDi6422621.
    KEGGicts:Ctha_1548.
    PATRICi21432031. VBIChlTha99257_1816.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001100 Genomic DNA. Translation: ACF14007.1 .
    RefSeqi WP_012500091.1. NC_011026.1.
    YP_001996454.1. NC_011026.1.

    3D structure databases

    ProteinModelPortali B3QS62.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 517418.Ctha_1548.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF14007 ; ACF14007 ; Ctha_1548 .
    GeneIDi 6422621.
    KEGGi cts:Ctha_1548.
    PATRICi 21432031. VBIChlTha99257_1816.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230372.
    KOi K00602.
    OMAi DEIACCA.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci CTHA517418:GHTO-1581-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Chloroherpeton thalassium ATCC 35110."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F.
      , Overmann J., Bryant D.A., Richardson P.
      Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35110 / GB-78.

    Entry informationi

    Entry nameiPUR9_CHLT3
    AccessioniPrimary (citable) accession number: B3QS62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3