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B3QRU2

- SYL_CHLT3

UniProt

B3QRU2 - SYL_CHLT3

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Protein

Leucine--tRNA ligase

Gene
leuS, Ctha_1432
Organism
Chloroherpeton thalassium (strain ATCC 35110 / GB-78)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTHA517418:GHTO-1460-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Ctha_1432
OrganismiChloroherpeton thalassium (strain ATCC 35110 / GB-78)
Taxonomic identifieri517418 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChloroherpeton
ProteomesiUP000001208: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 805805Leucine--tRNA ligaseUniRule annotationPRO_1000091306Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi517418.Ctha_1432.

Structurei

3D structure databases

ProteinModelPortaliB3QRU2.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotationAdd
BLAST
Motifi576 – 5805"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiVNIVTND.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

B3QRU2-1 [UniParc]FASTAAdd to Basket

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MKYDFTEIEK KWQAYWEQHQ TFKATEEPNK PKYYVLDMFP YPSGSGLHVG    50
HLEGYTASDI TARYKRLKGF SVLHPMGWDA FGLPAEQYAI KTGTHPRLTT 100
ETNVANFKST LQRMGFSYDW SREINTTDPG YVKWTQWIFL KLYEKGLAYV 150
DDVPVNWCEE LKVVLANEEV DEKVNDGYTV VRRPLRQWML KITAYAERLL 200
TDLDEVDWPE SVKEMQRNWI GKSVGAELDF YLAGTDEKFR IFTTRPDTVF 250
GATYMVLSPE HPLLDKITTD EHKSAVAAYR EEAERKSDLE RTGLQKEKTG 300
VFTGSYALNP ATGKEIPIWT SDFVLMGYGT GAIMSVPAHD ERDWEFAKKF 350
GIPIVEVIKS PHSVQEAVFA GKDSVCTNSE NAEISINGLA YEEAFEKITD 400
WFEKKGLGQR KVNYKLRDWL FSRQRYWGEP IPIKHYEDGA ERAETELPLN 450
LPEVSAYQPS GTGESPLANI AEWLYGEDEH GKFRRETNTM PQWAGSCWYY 500
LRFIDPDNPN EAVSPEKEKY WMNVDLYIGG AEHAVLHLLY ARFWHKVLYD 550
VGVVSTKEPF RKLFNQGMIL GEDNEKMSKS RGNVITADSV MSGYGADAVR 600
LYEMFLGPLE QVKPWSTNGI EGISRFLGKV WRLVYPNEAD GTVQVTDDAP 650
SETVLRRMHK TIKKVGEDTE TLKFNTAISE MMIYVNELQK EKCRSRTAIE 700
NLLLMLSPFA PHICEELWQA LGHEESITFA KFPEYDATLA KDDVVTIAVQ 750
VNGKLRGTFD AAAGLSKDDM IAEAMKVESV IKFTEGKEIV KQIAVPNKLV 800
NLVVK 805
Length:805
Mass (Da):91,951
Last modified:September 2, 2008 - v1
Checksum:iBF8D0259AE8672C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001100 Genomic DNA. Translation: ACF13895.1.
RefSeqiYP_001996342.1. NC_011026.1.

Genome annotation databases

EnsemblBacteriaiACF13895; ACF13895; Ctha_1432.
GeneIDi6422500.
KEGGicts:Ctha_1432.
PATRICi21431745. VBIChlTha99257_1678.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001100 Genomic DNA. Translation: ACF13895.1 .
RefSeqi YP_001996342.1. NC_011026.1.

3D structure databases

ProteinModelPortali B3QRU2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 517418.Ctha_1432.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF13895 ; ACF13895 ; Ctha_1432 .
GeneIDi 6422500.
KEGGi cts:Ctha_1432.
PATRICi 21431745. VBIChlTha99257_1678.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi VNIVTND.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CTHA517418:GHTO-1460-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Chloroherpeton thalassium ATCC 35110."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F.
    , Overmann J., Bryant D.A., Richardson P.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35110 / GB-78.

Entry informationi

Entry nameiSYL_CHLT3
AccessioniPrimary (citable) accession number: B3QRU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: June 11, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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