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B3QRU2

- SYL_CHLT3

UniProt

B3QRU2 - SYL_CHLT3

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chloroherpeton thalassium (strain ATCC 35110 / GB-78)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei579 – 5791ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCTHA517418:GHTO-1460-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Ctha_1432
    OrganismiChloroherpeton thalassium (strain ATCC 35110 / GB-78)
    Taxonomic identifieri517418 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChloroherpeton
    ProteomesiUP000001208: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 805805Leucine--tRNA ligasePRO_1000091306Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi517418.Ctha_1432.

    Structurei

    3D structure databases

    ProteinModelPortaliB3QRU2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi576 – 5805"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiVNIVTND.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B3QRU2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYDFTEIEK KWQAYWEQHQ TFKATEEPNK PKYYVLDMFP YPSGSGLHVG    50
    HLEGYTASDI TARYKRLKGF SVLHPMGWDA FGLPAEQYAI KTGTHPRLTT 100
    ETNVANFKST LQRMGFSYDW SREINTTDPG YVKWTQWIFL KLYEKGLAYV 150
    DDVPVNWCEE LKVVLANEEV DEKVNDGYTV VRRPLRQWML KITAYAERLL 200
    TDLDEVDWPE SVKEMQRNWI GKSVGAELDF YLAGTDEKFR IFTTRPDTVF 250
    GATYMVLSPE HPLLDKITTD EHKSAVAAYR EEAERKSDLE RTGLQKEKTG 300
    VFTGSYALNP ATGKEIPIWT SDFVLMGYGT GAIMSVPAHD ERDWEFAKKF 350
    GIPIVEVIKS PHSVQEAVFA GKDSVCTNSE NAEISINGLA YEEAFEKITD 400
    WFEKKGLGQR KVNYKLRDWL FSRQRYWGEP IPIKHYEDGA ERAETELPLN 450
    LPEVSAYQPS GTGESPLANI AEWLYGEDEH GKFRRETNTM PQWAGSCWYY 500
    LRFIDPDNPN EAVSPEKEKY WMNVDLYIGG AEHAVLHLLY ARFWHKVLYD 550
    VGVVSTKEPF RKLFNQGMIL GEDNEKMSKS RGNVITADSV MSGYGADAVR 600
    LYEMFLGPLE QVKPWSTNGI EGISRFLGKV WRLVYPNEAD GTVQVTDDAP 650
    SETVLRRMHK TIKKVGEDTE TLKFNTAISE MMIYVNELQK EKCRSRTAIE 700
    NLLLMLSPFA PHICEELWQA LGHEESITFA KFPEYDATLA KDDVVTIAVQ 750
    VNGKLRGTFD AAAGLSKDDM IAEAMKVESV IKFTEGKEIV KQIAVPNKLV 800
    NLVVK 805
    Length:805
    Mass (Da):91,951
    Last modified:September 2, 2008 - v1
    Checksum:iBF8D0259AE8672C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001100 Genomic DNA. Translation: ACF13895.1.
    RefSeqiYP_001996342.1. NC_011026.1.

    Genome annotation databases

    EnsemblBacteriaiACF13895; ACF13895; Ctha_1432.
    GeneIDi6422500.
    KEGGicts:Ctha_1432.
    PATRICi21431745. VBIChlTha99257_1678.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001100 Genomic DNA. Translation: ACF13895.1 .
    RefSeqi YP_001996342.1. NC_011026.1.

    3D structure databases

    ProteinModelPortali B3QRU2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 517418.Ctha_1432.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF13895 ; ACF13895 ; Ctha_1432 .
    GeneIDi 6422500.
    KEGGi cts:Ctha_1432.
    PATRICi 21431745. VBIChlTha99257_1678.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi VNIVTND.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CTHA517418:GHTO-1460-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Chloroherpeton thalassium ATCC 35110."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F.
      , Overmann J., Bryant D.A., Richardson P.
      Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35110 / GB-78.

    Entry informationi

    Entry nameiSYL_CHLT3
    AccessioniPrimary (citable) accession number: B3QRU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3