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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chloroherpeton thalassium (strain ATCC 35110 / GB-78)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTHA517418:GHTO-1460-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Ctha_1432
OrganismiChloroherpeton thalassium (strain ATCC 35110 / GB-78)
Taxonomic identifieri517418 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChloroherpeton
ProteomesiUP000001208 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 805805Leucine--tRNA ligasePRO_1000091306Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi517418.Ctha_1432.

Structurei

3D structure databases

ProteinModelPortaliB3QRU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi576 – 5805"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiEGAHRFI.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

B3QRU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYDFTEIEK KWQAYWEQHQ TFKATEEPNK PKYYVLDMFP YPSGSGLHVG
60 70 80 90 100
HLEGYTASDI TARYKRLKGF SVLHPMGWDA FGLPAEQYAI KTGTHPRLTT
110 120 130 140 150
ETNVANFKST LQRMGFSYDW SREINTTDPG YVKWTQWIFL KLYEKGLAYV
160 170 180 190 200
DDVPVNWCEE LKVVLANEEV DEKVNDGYTV VRRPLRQWML KITAYAERLL
210 220 230 240 250
TDLDEVDWPE SVKEMQRNWI GKSVGAELDF YLAGTDEKFR IFTTRPDTVF
260 270 280 290 300
GATYMVLSPE HPLLDKITTD EHKSAVAAYR EEAERKSDLE RTGLQKEKTG
310 320 330 340 350
VFTGSYALNP ATGKEIPIWT SDFVLMGYGT GAIMSVPAHD ERDWEFAKKF
360 370 380 390 400
GIPIVEVIKS PHSVQEAVFA GKDSVCTNSE NAEISINGLA YEEAFEKITD
410 420 430 440 450
WFEKKGLGQR KVNYKLRDWL FSRQRYWGEP IPIKHYEDGA ERAETELPLN
460 470 480 490 500
LPEVSAYQPS GTGESPLANI AEWLYGEDEH GKFRRETNTM PQWAGSCWYY
510 520 530 540 550
LRFIDPDNPN EAVSPEKEKY WMNVDLYIGG AEHAVLHLLY ARFWHKVLYD
560 570 580 590 600
VGVVSTKEPF RKLFNQGMIL GEDNEKMSKS RGNVITADSV MSGYGADAVR
610 620 630 640 650
LYEMFLGPLE QVKPWSTNGI EGISRFLGKV WRLVYPNEAD GTVQVTDDAP
660 670 680 690 700
SETVLRRMHK TIKKVGEDTE TLKFNTAISE MMIYVNELQK EKCRSRTAIE
710 720 730 740 750
NLLLMLSPFA PHICEELWQA LGHEESITFA KFPEYDATLA KDDVVTIAVQ
760 770 780 790 800
VNGKLRGTFD AAAGLSKDDM IAEAMKVESV IKFTEGKEIV KQIAVPNKLV

NLVVK
Length:805
Mass (Da):91,951
Last modified:September 2, 2008 - v1
Checksum:iBF8D0259AE8672C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001100 Genomic DNA. Translation: ACF13895.1.
RefSeqiWP_012499979.1. NC_011026.1.

Genome annotation databases

EnsemblBacteriaiACF13895; ACF13895; Ctha_1432.
KEGGicts:Ctha_1432.
PATRICi21431745. VBIChlTha99257_1678.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001100 Genomic DNA. Translation: ACF13895.1.
RefSeqiWP_012499979.1. NC_011026.1.

3D structure databases

ProteinModelPortaliB3QRU2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi517418.Ctha_1432.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACF13895; ACF13895; Ctha_1432.
KEGGicts:Ctha_1432.
PATRICi21431745. VBIChlTha99257_1678.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiEGAHRFI.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciCTHA517418:GHTO-1460-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Chloroherpeton thalassium ATCC 35110."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F.
    , Overmann J., Bryant D.A., Richardson P.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35110 / GB-78.

Entry informationi

Entry nameiSYL_CHLT3
AccessioniPrimary (citable) accession number: B3QRU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: July 22, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.