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B3QQ95

- UPPP_CHLP8

UniProt

B3QQ95 - UPPP_CHLP8

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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Chlorobaculum parvum (strain NCIB 8327) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 263 / NCIB 8327))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciCPAR517417:GH95-1748-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Cpar_1706
OrganismiChlorobaculum parvum (strain NCIB 8327) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 263 / NCIB 8327))
Taxonomic identifieri517417 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
ProteomesiUP000008811: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Undecaprenyl-diphosphatasePRO_1000197356Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi517417.Cpar_1706.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6021HelicalUniRule annotationAdd
BLAST
Transmembranei89 – 10921HelicalUniRule annotationAdd
BLAST
Transmembranei113 – 13321HelicalUniRule annotationAdd
BLAST
Transmembranei150 – 17021HelicalUniRule annotationAdd
BLAST
Transmembranei196 – 21621HelicalUniRule annotationAdd
BLAST
Transmembranei230 – 25021HelicalUniRule annotationAdd
BLAST
Transmembranei258 – 27821HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiAISEITW.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

B3QQ95-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLFQAIILG IVQGLTEFLP ISSSAHLRIV PALAGWDDPG AAFTAIVQIG
60 70 80 90 100
TLAAVLIYFM KDIISIVGAV VSDLLKGKPL ASDESRTGWM IAAGTIPIVV
110 120 130 140 150
FGLAFKDDIE TTLRSLYWVS AALIALALVL SIAEKHTSNR ARQGRRGKAI
160 170 180 190 200
SEITWLDAMI IGFAQAMALI PGSSRSGVTI TAGLFRNLDR ETSARFSFLL
210 220 230 240 250
SLPSVFAAGI YQLYKTWDVI TASTDNMINI AVATVFAFIF GYLSIAFLLT
260 270 280
YLKRHSTGIF IGYRLLLGIS LIIMIGTGHL MP
Length:282
Mass (Da):30,417
Last modified:September 2, 2008 - v1
Checksum:iF56ACA4D4C9EAAD2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001099 Genomic DNA. Translation: ACF12098.1.
RefSeqiWP_012502931.1. NC_011027.1.
YP_001999298.1. NC_011027.1.

Genome annotation databases

EnsemblBacteriaiACF12098; ACF12098; Cpar_1706.
GeneIDi6420647.
KEGGicpc:Cpar_1706.
PATRICi21366707. VBIChlPar72705_1707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001099 Genomic DNA. Translation: ACF12098.1 .
RefSeqi WP_012502931.1. NC_011027.1.
YP_001999298.1. NC_011027.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 517417.Cpar_1706.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF12098 ; ACF12098 ; Cpar_1706 .
GeneIDi 6420647.
KEGGi cpc:Cpar_1706.
PATRICi 21366707. VBIChlPar72705_1707.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi AISEITW.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci CPAR517417:GH95-1748-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCIB 8327.

Entry informationi

Entry nameiUPPP_CHLP8
AccessioniPrimary (citable) accession number: B3QQ95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3