Skip Header

Contribute Send feedback
Read comments (?) or add your own

B3QMF5 (SAHH_CHLP8) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenosylhomocysteinase
EC=3.3.1.1
Alternative name(s):
S-adenosyl-L-homocysteine hydrolase
Short name=AdoHcyase
Gene names
Name:ahcY
Ordered Locus Names:Cpar_0688
OrganismChlorobaculum parvum (strain NCIB 8327) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 263 / NCIB 8327)) [Complete proteome] [HAMAP]
Taxonomic identifier517417 [NCBI]
Taxonomic lineageBacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobaculum

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine By similarity. HAMAP MF_00563

Catalytic activity

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. HAMAP MF_00563

Cofactor

Binds 1 NAD per subunit By similarity. HAMAP MF_00563

Pathway

Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. HAMAP MF_00563

Subcellular location

Cytoplasm By similarity HAMAP MF_00563.

Sequence similarities

Belongs to the adenosylhomocysteinase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processone-carbon metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionadenosylhomocysteinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 471471Adenosylhomocysteinase HAMAP MF_00563
PRO_1000129276

Regions

Nucleotide binding197 – 1993NAD By similarity
Nucleotide binding260 – 2656NAD By similarity
Nucleotide binding339 – 3413NAD By similarity

Sites

Binding site601Substrate By similarity
Binding site1351Substrate By similarity
Binding site1961Substrate By similarity
Binding site2261Substrate By similarity
Binding site2301Substrate By similarity
Binding site2311NAD By similarity
Binding site2831NAD By similarity
Binding site3181NAD By similarity
Binding site3871NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
B3QMF5 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: 5C5B17AA210D370A

FASTA47152,107
        10         20         30         40         50         60 
MTTEAAVLDY KVADISLAEW GRKEIEIAEK EMPGLMATRK KYEGKKPLAG ARIAGSLHMT 

        70         80         90        100        110        120 
IQTAVLIETL VELGADVRWA SCNIFSTQDH AAAAIAAAGV PVFAWKGETL DEYWWCTRQI 

       130        140        150        160        170        180 
LEFEGGLGPN LIVDDGGDAT LMIHLGYKIE NDPSMLDKTP GNAEERALFA QLKEVFAEDN 

       190        200        210        220        230        240 
QRWHKVAAGM KGVSEETTTG VHRLYQMMEK GELLFPAINV NDSVTKSKFD NLYGCRESLA 

       250        260        270        280        290        300 
DGIKRATDVM IAGKVAVVLG YGDVGKGCAH SMRSYGARVI VTEIDPICAL QAAMEGFQVT 

       310        320        330        340        350        360 
TIEEALEEGN IYVTTTGNKD VITLEHMKKM KDEAIVCNIG HFDNEIQVDA LNNFKGATRI 

       370        380        390        400        410        420 
NIKPQVDKYV FEDGRCIYLL AEGRLVNLGC ATGHPSFVMS NSFTNQTLAQ IELWKNNYDV 

       430        440        450        460        470 
DVYRLPKHLD EEVARLHLGQ IGVKLTTLSK EQADYIGVPV EGPYKPEHYR Y

« Hide

References

[1]"Complete sequence of Chlorobaculum parvum NCIB 8327."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Zhao F., Li T., Liu Z. expand/collapse author list , Overmann J., Bryant D.A., Richardson P.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCIB 8327.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001099 Genomic DNA. Translation: ACF11108.1.
RefSeqYP_001998308.1. NC_011027.1.

3D structure databases

ProteinModelPortalB3QMF5.
ModBaseSearch...

Protein-protein interaction databases

STRINGB3QMF5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6419608.
GenomeReviewsGene locus Cpar_0688 in contig CP001099_GR.
KEGGcpc:Cpar_0688.
PATRIC21364614. VBIChlPar72705_0685.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG352029.
OMASAQVWVT.
ProtClustDBPRK05476.

Family and domain databases

HAMAPMF_00563. AdoHcyase.
[Tree]
InterProIPR000043. Adenosylhomocysteinase.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view]
KOK01251.
PANTHERPTHR23420. Ad_hcy_hydrolase. 1 hit.
PfamPF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view]
PIRSFPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTSM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00936. AhcY. 1 hit.
PROSITEPS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSAHH_CHLP8
AccessionPrimary (citable) accession number: B3QMF5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents