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B3QM32 (GCSPA_CHLP8) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Cpar_0563
OrganismChlorobaculum parvum (strain NCIB 8327) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 263 / NCIB 8327)) [Complete proteome] [HAMAP]
Taxonomic identifier517417 [NCBI]
Taxonomic lineageBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 444444Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000132474

Sequences

Sequence LengthMass (Da)Tools
B3QM32 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: D40F96871B1EE9D2

FASTA44447,665
        10         20         30         40         50         60 
MPFIVNTDAE RAEMLREIGV ENFEALIADI PEEVRLKKAL DLLPAMGEPE VKSLLEKMAS 

        70         80         90        100        110        120 
SNAATCDHVS FLGAGAYDHF IPAAVKTIAS RSEFYTAYTP YQAEVSQGTL QAIYEYQSVM 

       130        140        150        160        170        180 
CRLYGMDVAN ASMYDGASAL AEAALIALNV TGRNGIVVAG KLHPYTSQVL ETYLEAAGDR 

       190        200        210        220        230        240 
PIVQNSIEDG IGSVAALETL VSSETAAVIV QQPNFYGCLE EVEAIGEIAK KHGALFIVSA 

       250        260        270        280        290        300 
DPVSLGVLEA PGNYGADIAV GEGQSVGNAQ SFGGPYLGIL TVKQAHVRKI PGRLVGMTKD 

       310        320        330        340        350        360 
KDGNDGFILT LQTREQHIRR EKATSNICSN QALCALQAVV HLSLLGKEGI QDVANRSMQK 

       370        380        390        400        410        420 
AHYLADRITE LPGFSLKFSA PFFREFVVET PVPAATIIEK MLDKKVFAGV DLSAWGEDGL 

       430        440 
LIAVTEKRTK EELDSFVSEL ASLG 

« Hide

References

[1]"Complete sequence of Chlorobaculum parvum NCIB 8327."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Zhao F., Li T., Liu Z. expand/collapse author list , Overmann J., Bryant D.A., Richardson P.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCIB 8327.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001099 Genomic DNA. Translation: ACF10985.1.
RefSeqYP_001998185.1. NC_011027.1.

3D structure databases

ProteinModelPortalB3QM32.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING517417.Cpar_0563.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACF10985; ACF10985; Cpar_0563.
GeneID6419477.
KEGGcpc:Cpar_0563.
PATRIC21364358. VBIChlPar72705_0562.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMAYVRKIPG.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycCPAR517417:GH95-578-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_CHLP8
AccessionPrimary (citable) accession number: B3QM32
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families