Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chlorobaculum parvum (strain NCIB 8327) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 263 / NCIB 8327))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei579ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPAR517417:G1GC8-556-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Cpar_0539
OrganismiChlorobaculum parvum (strain NCIB 8327) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 263 / NCIB 8327))
Taxonomic identifieri517417 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
Proteomesi
  • UP000008811 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000913031 – 807Leucine--tRNA ligaseAdd BLAST807

Proteomic databases

PRIDEiB3QM08

Interactioni

Protein-protein interaction databases

STRINGi517417.Cpar_0539

Structurei

3D structure databases

ProteinModelPortaliB3QM08
SMRiB3QM08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi576 – 580"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit

Sequencei

Sequence statusi: Complete.

B3QM08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYDFSALEK KWQARWADEQ TFASSADQDK PKYYVLDMFP YPSGSGLHVG
60 70 80 90 100
HLEGYTATDI MARYKRCQGH NVLHPMGWDA FGLPAEQFAI KTGTHPRLTT
110 120 130 140 150
EKNVASFRET LKSMGFSYDW SREVNTTDPN YFKWTQWIFL KLYEKGLAYI
160 170 180 190 200
SEVDVNWCEE LKVVLANEEV DEKIADGYTV VRRPLRQWVL KITAYAERLL
210 220 230 240 250
EDLDEVDWPE NVKQMQRNWI GRSEGVEIDF ELRCHRTNLR VYTTRPDTLF
260 270 280 290 300
GATYLVISPE HPMAEKLAIA QQLVEVKKYI EQAKLKTELE RTGLQKEKTG
310 320 330 340 350
VFTGSYAINP ANGEALPVWI SDFVLTSYGT GAIMSVPAHD SRDWEFAKKF
360 370 380 390 400
GLPIREVIKS PHDVQEEVFD GKESVCVNSA NDEISIDGLD FKTAFDRMAT
410 420 430 440 450
WLESKGKGKR KVNYKLRDWV FSRQRYWGEP IPIKHYEDGT MRPETNLPLT
460 470 480 490 500
LPEVEAYHPT STGESPLANI ESWLYGEDEH GKFRRETNTM PQWAGSCWYY
510 520 530 540 550
LRFIDPQNGN ALVDPSREQY WMNVDLYIGG AEHAVLHLLY SRFWHKVLYD
560 570 580 590 600
LGVVSTKEPF QRLFNQGMIL GEDNEKMSKS RGNVIPADHV LSTYGADAVR
610 620 630 640 650
LYEMFLGPLE QVKPWNTHGI EGISRFLNKV WRLVWDENTE TQKTTDDKPS
660 670 680 690 700
EAVLKRMHKA IKKVTEDTEQ LKFNTAISEM MVLVNELTKT GCYSRETTET
710 720 730 740 750
LLVLLSPFAP HITEELWQTL GHTESISGAV WPVFDAKLAT DDVLTIAVQV
760 770 780 790 800
NGKLRGTFEA PAGYAKEDMI ESAKKVESVA KFLEGQQIIK EIAVPGKLVN

FAVKPQQ
Length:807
Mass (Da):92,556
Last modified:September 2, 2008 - v1
Checksum:iD495F8BEC478107D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001099 Genomic DNA Translation: ACF10961.1
RefSeqiWP_012501794.1, NC_011027.1

Genome annotation databases

EnsemblBacteriaiACF10961; ACF10961; Cpar_0539
KEGGicpc:Cpar_0539

Similar proteinsi

Entry informationi

Entry nameiSYL_CHLP8
AccessioniPrimary (citable) accession number: B3QM08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health