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B3QM08

- SYL_CHLP8

UniProt

B3QM08 - SYL_CHLP8

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chlorobaculum parvum (strain NCIB 8327) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 263 / NCIB 8327))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei579 – 5791ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPAR517417:GH95-554-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Cpar_0539
    OrganismiChlorobaculum parvum (strain NCIB 8327) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 263 / NCIB 8327))
    Taxonomic identifieri517417 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
    ProteomesiUP000008811: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 807807Leucine--tRNA ligasePRO_1000091303Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi517417.Cpar_0539.

    Structurei

    3D structure databases

    ProteinModelPortaliB3QM08.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi576 – 5805"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiERYWMNV.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B3QM08-1 [UniParc]FASTAAdd to Basket

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    MKYDFSALEK KWQARWADEQ TFASSADQDK PKYYVLDMFP YPSGSGLHVG    50
    HLEGYTATDI MARYKRCQGH NVLHPMGWDA FGLPAEQFAI KTGTHPRLTT 100
    EKNVASFRET LKSMGFSYDW SREVNTTDPN YFKWTQWIFL KLYEKGLAYI 150
    SEVDVNWCEE LKVVLANEEV DEKIADGYTV VRRPLRQWVL KITAYAERLL 200
    EDLDEVDWPE NVKQMQRNWI GRSEGVEIDF ELRCHRTNLR VYTTRPDTLF 250
    GATYLVISPE HPMAEKLAIA QQLVEVKKYI EQAKLKTELE RTGLQKEKTG 300
    VFTGSYAINP ANGEALPVWI SDFVLTSYGT GAIMSVPAHD SRDWEFAKKF 350
    GLPIREVIKS PHDVQEEVFD GKESVCVNSA NDEISIDGLD FKTAFDRMAT 400
    WLESKGKGKR KVNYKLRDWV FSRQRYWGEP IPIKHYEDGT MRPETNLPLT 450
    LPEVEAYHPT STGESPLANI ESWLYGEDEH GKFRRETNTM PQWAGSCWYY 500
    LRFIDPQNGN ALVDPSREQY WMNVDLYIGG AEHAVLHLLY SRFWHKVLYD 550
    LGVVSTKEPF QRLFNQGMIL GEDNEKMSKS RGNVIPADHV LSTYGADAVR 600
    LYEMFLGPLE QVKPWNTHGI EGISRFLNKV WRLVWDENTE TQKTTDDKPS 650
    EAVLKRMHKA IKKVTEDTEQ LKFNTAISEM MVLVNELTKT GCYSRETTET 700
    LLVLLSPFAP HITEELWQTL GHTESISGAV WPVFDAKLAT DDVLTIAVQV 750
    NGKLRGTFEA PAGYAKEDMI ESAKKVESVA KFLEGQQIIK EIAVPGKLVN 800
    FAVKPQQ 807
    Length:807
    Mass (Da):92,556
    Last modified:September 2, 2008 - v1
    Checksum:iD495F8BEC478107D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001099 Genomic DNA. Translation: ACF10961.1.
    RefSeqiWP_012501794.1. NC_011027.1.
    YP_001998161.1. NC_011027.1.

    Genome annotation databases

    EnsemblBacteriaiACF10961; ACF10961; Cpar_0539.
    GeneIDi6419453.
    KEGGicpc:Cpar_0539.
    PATRICi21364310. VBIChlPar72705_0538.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001099 Genomic DNA. Translation: ACF10961.1 .
    RefSeqi WP_012501794.1. NC_011027.1.
    YP_001998161.1. NC_011027.1.

    3D structure databases

    ProteinModelPortali B3QM08.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 517417.Cpar_0539.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF10961 ; ACF10961 ; Cpar_0539 .
    GeneIDi 6419453.
    KEGGi cpc:Cpar_0539.
    PATRICi 21364310. VBIChlPar72705_0538.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi ERYWMNV.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CPAR517417:GH95-554-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCIB 8327.

    Entry informationi

    Entry nameiSYL_CHLP8
    AccessioniPrimary (citable) accession number: B3QM08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3