B3QLF1 (GCST_CHLP8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	Cpar_0418

Organism

Chlorobaculum parvum (strain NCIB 8327) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 263 / NCIB 8327)) [Complete proteome] [HAMAP]

Taxonomic identifier

517417 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobaculum

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 365	365	Aminomethyltransferase HAMAP MF_00259		PRO_1000114087

Sequences

	Sequence		Length	Mass (Da)
	B3QLF1 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: 24CE49FC5A66073B	FASTA	365	39,958
	10 20 30 40 50 60 MKKTALSAWH EGAGAKMIDF GGFLMPVQYS GIIAEHKAVR EAAGLFDVSH MGNFYVRGER 70 80 90 100 110 120 ALEFLQYVTT NDLGKIVDGQ AQYTLMLYPD GGIVDDLIIY RVSADTFFLI VNASNCEKDF 130 140 150 160 170 180 AWLSDHVGGF EGVTLENRTS ELSLIALQGP KAFEVLGRVF PEAGLDKLAS FHFATVPFGG 190 200 210 220 230 240 AEAMVARTGY TGEAGVEICL PNEEAEALWT ALMAAGKNDG IQPIGLGARD TLRLEMGYSL 250 260 270 280 290 300 YGHEIDQTVN PLEARLKWVV KMDKPNFIGK QACQQVELDP RKSVVGFSLD GRAIPRQHFK 310 320 330 340 350 360 VYNSDKQEIG EVCSGTVSPT LQEPIGTASL LRDYAKTGTP IFVEIRGTFQ PGTVRRLPFV HADRP

References

[1]

"Complete sequence of Chlorobaculum parvum NCIB 8327." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Zhao F., Li T., Liu Z. , Overmann J., Bryant D.A., Richardson P. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCIB 8327.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001099 Genomic DNA. Translation: ACF10841.1.
RefSeq	YP_001998041.1. NC_011027.1.
3D structure databases
ProteinModelPortal	B3QLF1.
ModBase	Search...
Protein-protein interaction databases
STRING	B3QLF1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6419332.
GenomeReviews	Gene locus Cpar_0418 in contig CP001099_GR.
KEGG	cpc:Cpar_0418.
PATRIC	21364062. VBIChlPar72705_0414.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG299834.
OMA	KALYGGM.
ProtClustDB	PRK00389.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_CHLP8

Accession

Primary (citable) accession number: B3QLF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 2, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program