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Protein

Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

Gene

menH

Organism
Chlorobaculum parvum (strain NCIB 8327) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 263 / NCIB 8327))
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).UniRule annotationSAAS annotation

Catalytic activityi

5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate.UniRule annotationSAAS annotation

Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotationSAAS annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Isochorismate synthase MenF (menF)
  2. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (menD)
  3. Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (menH)
  4. o-succinylbenzoate synthase (menC)
  5. no protein annotated in this organism
  6. 1,4-dihydroxy-2-naphthoyl-CoA synthase (menB)
  7. no protein annotated in this organism
This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.

Pathwayi: menaquinone biosynthesis

This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseImported, LyaseUniRule annotationSAAS annotation
Biological processMenaquinone biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00079.
UPA01057; UER00900.

Protein family/group databases

ESTHERichlp8-b3qkz4. MenH_SHCHC.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthaseUniRule annotation (EC:4.2.99.20UniRule annotation)
Short name:
SHCHC synthaseUniRule annotation
Gene namesi
Name:menHUniRule annotation
Ordered Locus Names:Cpar_0358Imported
OrganismiChlorobaculum parvum (strain NCIB 8327) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 263 / NCIB 8327))Imported
Taxonomic identifieri517417 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
Proteomesi
  • UP000008811 Componenti: Chromosome

Interactioni

Subunit structurei

Monomer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi517417.Cpar_0358.

Structurei

3D structure databases

ProteinModelPortaliB3QKZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 255AB hydrolase-1InterPro annotationAdd BLAST237

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. MenH family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107J5P. Bacteria.
COG0596. LUCA.
HOGENOMiHOG000028072.
KOiK08680.
OMAiLNDWYQQ.
OrthoDBiPOG091H05R7.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_01660. MenH. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR022485. SHCHC_synthase_MenH.
PfamiView protein in Pfam
PF12697. Abhydrolase_6. 1 hit.
PRINTSiPR00111. ABHYDROLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR03695. menH_SHCHC. 1 hit.

Sequencei

Sequence statusi: Complete.

B3QKZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNIPLHLTT VGNPSLPKIV FLHGFLGSGS DWLSFARKLE DRFCSILVDL
60 70 80 90 100
PGHGETGIPA DGDPELFFMQ TVEALAGEIR QLSAGPCVLV GYSMGGRIGL
110 120 130 140 150
ALTLRYPELF SKAVIVSSSP GLRTEEEHAA RRKSDEGIAR KIERNFEGFI
160 170 180 190 200
QFWYDQPLFA TLKSHDLFHE VEAQRKQGSP ENLACALRLL GTGNQPSFWD
210 220 230 240 250
ELPGNLLPML FCVGEKDAKY VEIGKQMVEL CPQSSLELFE HCGHTLHIEE
260 270
PERFLASVSG LSKSKTEISL TKEFVP
Length:276
Mass (Da):30,555
Last modified:September 2, 2008 - v1
Checksum:i2223AC1871BB4806
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001099 Genomic DNA. Translation: ACF10782.1.
RefSeqiWP_012501615.1. NC_011027.1.

Genome annotation databases

EnsemblBacteriaiACF10782; ACF10782; Cpar_0358.
KEGGicpc:Cpar_0358.

Similar proteinsi

Entry informationi

Entry nameiB3QKZ4_CHLP8
AccessioniPrimary (citable) accession number: B3QKZ4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: September 27, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported