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B3QKU1

- MASZ_RHOPT

UniProt

B3QKU1 - MASZ_RHOPT

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Protein
Malate synthase G
Gene
glcB, Rpal_4697
Organism
Rhodopseudomonas palustris (strain TIE-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei117 – 1171Acetyl-CoA; via carbonyl oxygen By similarity
Binding sitei273 – 2731Acetyl-CoA By similarity
Binding sitei310 – 3101Acetyl-CoA By similarity
Active sitei337 – 3371Proton acceptor By similarity
Binding sitei337 – 3371Glyoxylate By similarity
Metal bindingi429 – 4291Magnesium By similarity
Binding sitei429 – 4291Glyoxylate By similarity
Metal bindingi457 – 4571Magnesium By similarity
Binding sitei538 – 5381Acetyl-CoA; via carbonyl oxygen By similarity
Active sitei628 – 6281Proton donor By similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciRPAL395960:GHPC-4742-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase G (EC:2.3.3.9)
Gene namesi
Name:glcB
Ordered Locus Names:Rpal_4697
OrganismiRhodopseudomonas palustris (strain TIE-1)
Taxonomic identifieri395960 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000001725: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 724724Malate synthase GUniRule annotation
PRO_1000130897Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei614 – 6141Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi395960.Rpal_4697.

Structurei

3D structure databases

ProteinModelPortaliB3QKU1.
SMRiB3QKU1. Positions 9-721.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni124 – 1252Acetyl-CoA binding By similarity
Regioni454 – 4574Glyoxylate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSQFIENE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

B3QKU1-1 [UniParc]FASTAAdd to Basket

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MNRIDAHGLK IAPVLFDFIA KEAAPKTGIA PDVFWAGLAA IVRDLAPKTR    50
ALLKTRDDLQ AKIDAWHLAN KGKKQDMAAY TAFLKEIGYL LPEPPTVPVE 100
TANIDEEIGK LCGPQLVVPL SNARYALNAA NARWGSLYDA FYGTDAIPQE 150
ATQAKGYDKA RGDKVIAKAK AFLDQAAPLA TGSHSDVTGY SVIAGQLSAK 200
LKSGNATGLK KPAQFAGFRG DAANPSAVLL VNNGLHIEIK IDRANTIGKD 250
DPAGVADLVI ESAVSTILDM EDSVAAVDAD DKVLIYRNTL GLMDGTLSES 300
FEKGGKTVTR ALNGDRTYTA PDGKEISLHG RSLLLMRNVG HHMWTDAVLD 350
SDGQEIPEGF LDAAVSGLIA IHDLKHLGKT RNSRTGSVYI VKPKMHGPDE 400
VALTVELFGR VETMLGLTAN TLKVGIMDEE RRTTVNLKAC IQNASKRIVF 450
INTGFLDRTG DEIHTSMEAG PMIRKNEMKA QPWIKAYEDW NVDTGLVDGL 500
PGHAQIGKGM WAAPDKMADM LAQKIGHPQA GATTAWVPSP TAATLHALHY 550
HQVDVIARQQ ELAKGGPRAK LEDILTIPVS NSNWAPDDVR QEIDNNCQGI 600
LGYVVRWIDQ GVGCSKVPDI HDVGLMEDRA TLRISSQHLA NWLHHGVVTK 650
DQVLDSLKRM AVIVDKQNEG DALYRPIAPD FDGVAFEAAC DLIFKGRAQP 700
NGYTEYILHE RRREAKAAHL ESAR 724
Length:724
Mass (Da):78,535
Last modified:September 2, 2008 - v1
Checksum:i0102198CFF95EEFC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001096 Genomic DNA. Translation: ACF03188.1.
RefSeqiYP_001993663.1. NC_011004.1.

Genome annotation databases

EnsemblBacteriaiACF03188; ACF03188; Rpal_4697.
GeneIDi6412383.
KEGGirpt:Rpal_4697.
PATRICi23313936. VBIRhoPal88240_4755.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001096 Genomic DNA. Translation: ACF03188.1 .
RefSeqi YP_001993663.1. NC_011004.1.

3D structure databases

ProteinModelPortali B3QKU1.
SMRi B3QKU1. Positions 9-721.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 395960.Rpal_4697.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF03188 ; ACF03188 ; Rpal_4697 .
GeneIDi 6412383.
KEGGi rpt:Rpal_4697.
PATRICi 23313936. VBIRhoPal88240_4755.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi SQFIENE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci RPAL395960:GHPC-4742-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TIE-1.

Entry informationi

Entry nameiMASZ_RHOPT
AccessioniPrimary (citable) accession number: B3QKU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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