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B3QH88

- GLPK_RHOPT

UniProt

B3QH88 - GLPK_RHOPT

Protein

Glycerol kinase

Gene

glpK

Organism
Rhodopseudomonas palustris (strain TIE-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotation

    Catalytic activityi

    ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

    Enzyme regulationi

    Inhibited by fructose 1,6-bisphosphate (FBP).UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111SubstrateUniRule annotation
    Binding sitei15 – 151ATPUniRule annotation
    Binding sitei133 – 1331SubstrateUniRule annotation
    Binding sitei264 – 2641ATPUniRule annotation
    Binding sitei307 – 3071ATP; via carbonyl oxygenUniRule annotation
    Binding sitei311 – 3111ATP; via amide nitrogenUniRule annotation
    Binding sitei326 – 3261ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 133ATPUniRule annotation
    Nucleotide bindingi411 – 4155ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glycerol kinase activity Source: UniProtKB

    GO - Biological processi

    1. glycerol-3-phosphate metabolic process Source: UniProtKB-HAMAP
    2. glycerol catabolic process Source: UniProtKB-UniPathway
    3. glycerol metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycerol metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRPAL395960:GHPC-4269-MONOMER.
    UniPathwayiUPA00618; UER00672.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
    Alternative name(s):
    ATP:glycerol 3-phosphotransferaseUniRule annotation
    GlycerokinaseUniRule annotation
    Short name:
    GKUniRule annotation
    Gene namesi
    Name:glpKUniRule annotation
    Ordered Locus Names:Rpal_4226
    OrganismiRhodopseudomonas palustris (strain TIE-1)
    Taxonomic identifieri395960 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
    ProteomesiUP000001725: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Glycerol kinasePRO_1000098753Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi395960.Rpal_4226.

    Structurei

    3D structure databases

    ProteinModelPortaliB3QH88.
    SMRiB3QH88. Positions 3-494.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni81 – 822Substrate bindingUniRule annotation
    Regioni242 – 2432Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the FGGY kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0554.
    HOGENOMiHOG000222134.
    KOiK00864.
    OMAiHFFGVEV.
    OrthoDBiEOG6RZB46.

    Family and domain databases

    HAMAPiMF_00186. Glycerol_kin.
    InterProiIPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR005999. Glycerol_kin.
    [Graphical view]
    PfamiPF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
    PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
    PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3QH88-1 [UniParc]FASTAAdd to Basket

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    MPFVMAIDQG TTSSRAILFR SDISIAASAQ QEFPQHFPAS GWVEHEPEDI    50
    WATTIATCRA AMDKAGATAA DIAAIGITNQ RETVVVWDAV SGQAIHRAIV 100
    WQDRRTAEFC TRLKAEGLEP MVTAKTGLII DPYFSGTKVA WLLDNVPGAR 150
    ARAERGELKF GTVDCYLLWR LTGGKVHATD ATNASRTLLF NIHDGAWDDE 200
    LLKLLGVPRS MLPEVKDSSA HFGDSVPELF GGSITIRGIA GDQQAATIGQ 250
    ACFTPGMIKS TYGTGCFALL NTGATPVKSN NKLLTTVAYQ LGGKRTYALE 300
    GSIFVAGSAV QWLRDGLGVI KHASETGPLA DKSDSAQSVY LVPAFVGMGA 350
    PYWNPRVRGA LFGLTRNTGP AELAHAALES VCYQTFDLWA AMRADWPDAD 400
    AATTVLRVDG GMTASDWTMQ RLADLLDAPV DRPVIQETTA LGAAYLAGLS 450
    AGVFPEPQKF ADNWRLDHRF RPAMSAATRE RKLAGWARAV RGLLATDEGE 500
    Length:500
    Mass (Da):53,761
    Last modified:September 2, 2008 - v1
    Checksum:i384BA6073C542196
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001096 Genomic DNA. Translation: ACF02722.1.
    RefSeqiWP_012497107.1. NC_011004.1.
    YP_001993197.1. NC_011004.1.

    Genome annotation databases

    EnsemblBacteriaiACF02722; ACF02722; Rpal_4226.
    GeneIDi6411910.
    KEGGirpt:Rpal_4226.
    PATRICi23312959. VBIRhoPal88240_4270.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001096 Genomic DNA. Translation: ACF02722.1 .
    RefSeqi WP_012497107.1. NC_011004.1.
    YP_001993197.1. NC_011004.1.

    3D structure databases

    ProteinModelPortali B3QH88.
    SMRi B3QH88. Positions 3-494.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 395960.Rpal_4226.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF02722 ; ACF02722 ; Rpal_4226 .
    GeneIDi 6411910.
    KEGGi rpt:Rpal_4226.
    PATRICi 23312959. VBIRhoPal88240_4270.

    Phylogenomic databases

    eggNOGi COG0554.
    HOGENOMi HOG000222134.
    KOi K00864.
    OMAi HFFGVEV.
    OrthoDBi EOG6RZB46.

    Enzyme and pathway databases

    UniPathwayi UPA00618 ; UER00672 .
    BioCyci RPAL395960:GHPC-4269-MONOMER.

    Family and domain databases

    HAMAPi MF_00186. Glycerol_kin.
    InterProi IPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR005999. Glycerol_kin.
    [Graphical view ]
    Pfami PF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
    PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
    PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TIE-1.

    Entry informationi

    Entry nameiGLPK_RHOPT
    AccessioniPrimary (citable) accession number: B3QH88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3