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B3QH88

- GLPK_RHOPT

UniProt

B3QH88 - GLPK_RHOPT

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Protein
Glycerol kinase
Gene
glpK, Rpal_4226
Organism
Rhodopseudomonas palustris (strain TIE-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate By similarity.UniRule annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

Enzyme regulationi

Inhibited by fructose 1,6-bisphosphate (FBP) By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111Substrate By similarity
Binding sitei15 – 151ATP By similarity
Binding sitei133 – 1331Substrate By similarity
Binding sitei264 – 2641ATP By similarity
Binding sitei307 – 3071ATP; via carbonyl oxygen By similarity
Binding sitei311 – 3111ATP; via amide nitrogen By similarity
Binding sitei326 – 3261ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 133ATP By similarity
Nucleotide bindingi411 – 4155ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glycerol kinase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. glycerol catabolic process Source: UniProtKB-UniPathway
  2. glycerol metabolic process Source: UniProtKB
  3. glycerol-3-phosphate metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRPAL395960:GHPC-4269-MONOMER.
UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinase (EC:2.7.1.30)
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name:
GK
Gene namesi
Name:glpK
Ordered Locus Names:Rpal_4226
OrganismiRhodopseudomonas palustris (strain TIE-1)
Taxonomic identifieri395960 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000001725: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Glycerol kinaseUniRule annotation
PRO_1000098753Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi395960.Rpal_4226.

Structurei

3D structure databases

ProteinModelPortaliB3QH88.
SMRiB3QH88. Positions 3-494.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni81 – 822Substrate binding By similarity
Regioni242 – 2432Substrate binding By similarity

Sequence similaritiesi

Belongs to the FGGY kinase family.

Phylogenomic databases

eggNOGiCOG0554.
HOGENOMiHOG000222134.
KOiK00864.
OMAiHFFGVEV.
OrthoDBiEOG6RZB46.

Family and domain databases

HAMAPiMF_00186. Glycerol_kin.
InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3QH88-1 [UniParc]FASTAAdd to Basket

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MPFVMAIDQG TTSSRAILFR SDISIAASAQ QEFPQHFPAS GWVEHEPEDI    50
WATTIATCRA AMDKAGATAA DIAAIGITNQ RETVVVWDAV SGQAIHRAIV 100
WQDRRTAEFC TRLKAEGLEP MVTAKTGLII DPYFSGTKVA WLLDNVPGAR 150
ARAERGELKF GTVDCYLLWR LTGGKVHATD ATNASRTLLF NIHDGAWDDE 200
LLKLLGVPRS MLPEVKDSSA HFGDSVPELF GGSITIRGIA GDQQAATIGQ 250
ACFTPGMIKS TYGTGCFALL NTGATPVKSN NKLLTTVAYQ LGGKRTYALE 300
GSIFVAGSAV QWLRDGLGVI KHASETGPLA DKSDSAQSVY LVPAFVGMGA 350
PYWNPRVRGA LFGLTRNTGP AELAHAALES VCYQTFDLWA AMRADWPDAD 400
AATTVLRVDG GMTASDWTMQ RLADLLDAPV DRPVIQETTA LGAAYLAGLS 450
AGVFPEPQKF ADNWRLDHRF RPAMSAATRE RKLAGWARAV RGLLATDEGE 500
Length:500
Mass (Da):53,761
Last modified:September 2, 2008 - v1
Checksum:i384BA6073C542196
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001096 Genomic DNA. Translation: ACF02722.1.
RefSeqiWP_012497107.1. NC_011004.1.
YP_001993197.1. NC_011004.1.

Genome annotation databases

EnsemblBacteriaiACF02722; ACF02722; Rpal_4226.
GeneIDi6411910.
KEGGirpt:Rpal_4226.
PATRICi23312959. VBIRhoPal88240_4270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001096 Genomic DNA. Translation: ACF02722.1 .
RefSeqi WP_012497107.1. NC_011004.1.
YP_001993197.1. NC_011004.1.

3D structure databases

ProteinModelPortali B3QH88.
SMRi B3QH88. Positions 3-494.
ModBasei Search...

Protein-protein interaction databases

STRINGi 395960.Rpal_4226.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF02722 ; ACF02722 ; Rpal_4226 .
GeneIDi 6411910.
KEGGi rpt:Rpal_4226.
PATRICi 23312959. VBIRhoPal88240_4270.

Phylogenomic databases

eggNOGi COG0554.
HOGENOMi HOG000222134.
KOi K00864.
OMAi HFFGVEV.
OrthoDBi EOG6RZB46.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00672 .
BioCyci RPAL395960:GHPC-4269-MONOMER.

Family and domain databases

HAMAPi MF_00186. Glycerol_kin.
InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TIE-1.

Entry informationi

Entry nameiGLPK_RHOPT
AccessioniPrimary (citable) accession number: B3QH88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: September 3, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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