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B3QH88

- GLPK_RHOPT

UniProt

B3QH88 - GLPK_RHOPT

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Protein

Glycerol kinase

Gene

glpK

Organism
Rhodopseudomonas palustris (strain TIE-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

Enzyme regulationi

Inhibited by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111SubstrateUniRule annotation
Binding sitei15 – 151ATPUniRule annotation
Binding sitei133 – 1331SubstrateUniRule annotation
Binding sitei264 – 2641ATPUniRule annotation
Binding sitei307 – 3071ATP; via carbonyl oxygenUniRule annotation
Binding sitei311 – 3111ATP; via amide nitrogenUniRule annotation
Binding sitei326 – 3261ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 133ATPUniRule annotation
Nucleotide bindingi411 – 4155ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glycerol kinase activity Source: UniProtKB

GO - Biological processi

  1. glycerol-3-phosphate metabolic process Source: UniProtKB-HAMAP
  2. glycerol catabolic process Source: UniProtKB-UniPathway
  3. glycerol metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRPAL395960:GHPC-4269-MONOMER.
UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
Alternative name(s):
ATP:glycerol 3-phosphotransferaseUniRule annotation
GlycerokinaseUniRule annotation
Short name:
GKUniRule annotation
Gene namesi
Name:glpKUniRule annotation
Ordered Locus Names:Rpal_4226
OrganismiRhodopseudomonas palustris (strain TIE-1)
Taxonomic identifieri395960 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000001725: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Glycerol kinasePRO_1000098753Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi395960.Rpal_4226.

Structurei

3D structure databases

ProteinModelPortaliB3QH88.
SMRiB3QH88. Positions 3-494.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni81 – 822Substrate bindingUniRule annotation
Regioni242 – 2432Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the FGGY kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0554.
HOGENOMiHOG000222134.
KOiK00864.
OMAiHFFGVEV.
OrthoDBiEOG6RZB46.

Family and domain databases

HAMAPiMF_00186. Glycerol_kin.
InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3QH88 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPFVMAIDQG TTSSRAILFR SDISIAASAQ QEFPQHFPAS GWVEHEPEDI
60 70 80 90 100
WATTIATCRA AMDKAGATAA DIAAIGITNQ RETVVVWDAV SGQAIHRAIV
110 120 130 140 150
WQDRRTAEFC TRLKAEGLEP MVTAKTGLII DPYFSGTKVA WLLDNVPGAR
160 170 180 190 200
ARAERGELKF GTVDCYLLWR LTGGKVHATD ATNASRTLLF NIHDGAWDDE
210 220 230 240 250
LLKLLGVPRS MLPEVKDSSA HFGDSVPELF GGSITIRGIA GDQQAATIGQ
260 270 280 290 300
ACFTPGMIKS TYGTGCFALL NTGATPVKSN NKLLTTVAYQ LGGKRTYALE
310 320 330 340 350
GSIFVAGSAV QWLRDGLGVI KHASETGPLA DKSDSAQSVY LVPAFVGMGA
360 370 380 390 400
PYWNPRVRGA LFGLTRNTGP AELAHAALES VCYQTFDLWA AMRADWPDAD
410 420 430 440 450
AATTVLRVDG GMTASDWTMQ RLADLLDAPV DRPVIQETTA LGAAYLAGLS
460 470 480 490 500
AGVFPEPQKF ADNWRLDHRF RPAMSAATRE RKLAGWARAV RGLLATDEGE
Length:500
Mass (Da):53,761
Last modified:September 2, 2008 - v1
Checksum:i384BA6073C542196
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001096 Genomic DNA. Translation: ACF02722.1.
RefSeqiYP_001993197.1. NC_011004.1.

Genome annotation databases

EnsemblBacteriaiACF02722; ACF02722; Rpal_4226.
GeneIDi6411910.
KEGGirpt:Rpal_4226.
PATRICi23312959. VBIRhoPal88240_4270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001096 Genomic DNA. Translation: ACF02722.1 .
RefSeqi YP_001993197.1. NC_011004.1.

3D structure databases

ProteinModelPortali B3QH88.
SMRi B3QH88. Positions 3-494.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 395960.Rpal_4226.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF02722 ; ACF02722 ; Rpal_4226 .
GeneIDi 6411910.
KEGGi rpt:Rpal_4226.
PATRICi 23312959. VBIRhoPal88240_4270.

Phylogenomic databases

eggNOGi COG0554.
HOGENOMi HOG000222134.
KOi K00864.
OMAi HFFGVEV.
OrthoDBi EOG6RZB46.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00672 .
BioCyci RPAL395960:GHPC-4269-MONOMER.

Family and domain databases

HAMAPi MF_00186. Glycerol_kin.
InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TIE-1.

Entry informationi

Entry nameiGLPK_RHOPT
AccessioniPrimary (citable) accession number: B3QH88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3