Reviewed, UniProtKB/Swiss-Prot B3QB98 (HGD_RHOPT)

Names and origin

Protein names

Recommended name:
    Homogentisate 1,2-dioxygenase
    EC=1.13.11.5
Alternative name(s):
    Homogentisicase
    Homogentisate oxygenase
    Homogentisic acid oxidase

Gene names

Name:	hmgA
Ordered Locus Names:	Rpal_5153

Organism

Rhodopseudomonas palustris (strain TIE-1) [Complete proteome] [HAMAP]

Taxonomic identifier

395960 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Homogentisate + O2 = 4-maleylacetoacetate. HAMAP MF_00334
Cofactor	Iron By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP MF_00334
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Homogentisate 1,2-dioxygenase HAMAP MF_00334		PRO_1000119850
Sites
	Metal binding	346	1	Iron By similarity
	Metal binding	352	1	Iron By similarity
	Metal binding	382	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	B3QB98-1 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: 295E932DD13B8C04	FASTA	448	49,832
	10 20 30 40 50 60 MNINAAPQIL GRSSQDITPG YMSGFGNSFE TEALPGALPV GRNSPQRCAY GLYAEQLSGS 70 80 90 100 110 120 PFTAPRGANE RSWLYRIRPS VKHSGRFAKT DMGLWRSAPC FEHDLPIAQL RWDPPPMPQE 130 140 150 160 170 180 KLTFLQGVRT MTTAGDVNTQ AGMATHLYLI TQSMVDQHFY NADGEMMFVP QQGSLRLVTE 190 200 210 220 230 240 FGIITIEPAE IAVIPRGIKF RVELVDGPAR GYLCENYGGA FTLPERGPIG ANCLANSRDF 250 260 270 280 290 300 LTPVAAYEDK DTPTELYVKW GGSLYVTKLP HSPIDVVAWH GNYAPYKYDL RTYSPVGAIG 310 320 330 340 350 360 FDHPDPSIFT VLTSPSETPG TANIDFVIFP ERWMVADNTF RPPWYHMNIM SEFMGLIYGV 370 380 390 400 410 420 YDAKPQGFVP GGASLHNMML PHGPDREAFD HASNGELKPV KLTGTMAFMF ETRYPQRVTE 430 440 YAASSGLLQD DYADCWNGLE KRFDPNRP

References

[1]

"Complete sequence of Rhodopseudomonas palustris TIE-1." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Emerson D., Newman D.K., Roden E., Richardson P. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001096 Genomic DNA. Translation: ACF03641.1.
RefSeq	YP_001994116.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6412853.
GenomeReviews	Gene locus Rpal_5153 in contig CP001096_GR.
KEGG	rpt:Rpal_5153.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	HRNCMSE.
Family and domain databases
HAMAP	MF_00334. [Tree]
InterPro	IPR005708. Homogentis_dOase. [Graphical view]
PANTHER	PTHR11056. Homogentis_dOase. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01015. hmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_RHOPT

Accession

Primary (citable) accession number: B3QB98

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 2, 2008
Last modified:	November 3, 2009
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)