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Protein

Acetate kinase

Gene

ackA

Organism
Rhodopseudomonas palustris (strain TIE-1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9MagnesiumUniRule annotation1
Binding sitei16ATPUniRule annotation1
Binding sitei93SubstrateUniRule annotation1
Active sitei150Proton donor/acceptorUniRule annotation1
Sitei181Transition state stabilizerUniRule annotation1
Sitei242Transition state stabilizerUniRule annotation1
Metal bindingi382MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi209 – 213ATPUniRule annotation5
Nucleotide bindingi284 – 286ATPUniRule annotation3
Nucleotide bindingi329 – 333ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:Rpal_5046
OrganismiRhodopseudomonas palustris (strain TIE-1)
Taxonomic identifieri395960 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000001725 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000899921 – 398Acetate kinaseAdd BLAST398

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB3QA57.
SMRiB3QA57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000288399.
KOiK00925.
OMAiAMEEGHE.
OrthoDBiPOG091H02K4.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiView protein in InterPro
IPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiView protein in Pfam
PF00871. Acetate_kinase. 1 hit.
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiView protein in PROSITE
PS01075. ACETATE_KINASE_1. 1 hit.

Sequencei

Sequence statusi: Complete.

B3QA57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDVLLVLNA GSSSIKFALY EAHTEPTADH LICEGGIGSL GHRPHFKVVN
60 70 80 90 100
SDGSTRYDTY LPEGTSHDDA MAVLIGWIET TFPEHRLSAV GHRVVHGGAL
110 120 130 140 150
FDGPVDVTPE VIAQLRAFDR LAPLHQPHNV SAIEALAKLH PSLTQIACFD
160 170 180 190 200
TAFHHRLPEV ATAFALPREL TEQGVRRYGF HGLSYEYIAG RLPDVAGQAV
210 220 230 240 250
ADGRVVVAHL GAGASMCAML RCRSIATTMG FTALDGLMMG SRCGELDPGV
260 270 280 290 300
VLYLLEEKSM TAREIEDLLY RESGLLGVSG ISDDMRTLLA SDDPHACEAI
310 320 330 340 350
ELFVYRIARE LGSLAAALGG LDALVFTGGI GEHASEIRRR VCEQAAWLGV
360 370 380 390
TLDPDANARL SGAGRISAPD SKVSAWAIPT DEDLMIARHV WRLADGGR
Length:398
Mass (Da):42,736
Last modified:September 2, 2008 - v1
Checksum:iB39A5A408BAAA194
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001096 Genomic DNA. Translation: ACF03535.1.
RefSeqiWP_012497726.1. NC_011004.1.

Genome annotation databases

EnsemblBacteriaiACF03535; ACF03535; Rpal_5046.
KEGGirpt:Rpal_5046.

Similar proteinsi

Entry informationi

Entry nameiACKA_RHOPT
AccessioniPrimary (citable) accession number: B3QA57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: June 7, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families