B3Q6U2 (KHSE_RHOPT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Rpal_4750

Organism

Rhodopseudomonas palustris (strain TIE-1) [Complete proteome] [HAMAP]

Taxonomic identifier

395960 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 327	327	Homoserine kinase HAMAP MF_00301		PRO_1000115441

Sequences

	Sequence		Length	Mass (Da)
	B3Q6U2 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: 6574D68EDE5BAD80	FASTA	327	35,807
	10 20 30 40 50 60 MAVYTDVAAD ELADFLSRYD IGDLLSYKGI AEGVENSNFL LHTSRGYFIL TLYEKRVARD 70 80 90 100 110 120 DLPFFLSLMT HLADSGINCP QPVADREGRT LATLAGRPAA IISFLDGVWP RKPSVVHCAG 130 140 150 160 170 180 VGQALAKMHL AGRDFAMKRA NALSVAGWRP LFAAAEARAD EVQPGLRDFL AAELSYLESG 190 200 210 220 230 240 VWPSDLPQGL IHADLFPDNV FFIGDDVSGI IDFTFACNDL LAYDVAICLN AWCFEADHAF 250 260 270 280 290 300 NVTKARALLS AYTRERPLDA AEQAALPLLA RGAALRFLLT RLVDWLNVPE GALVKPKDPM 310 320 EYVRKLRFQQ NVAGIRDYGV EIAGAVA

References

[1]

"Complete sequence of Rhodopseudomonas palustris TIE-1." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Emerson D., Newman D.K., Roden E., Richardson P. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TIE-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001096 Genomic DNA. Translation: ACF03241.1.
RefSeq	YP_001993716.1. NC_011004.1.
3D structure databases
ProteinModelPortal	B3Q6U2.
SMR	B3Q6U2. Positions 5-320.
ModBase	Search...
Protein-protein interaction databases
STRING	B3Q6U2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6412436.
GenomeReviews	Gene locus Rpal_4750 in contig CP001096_GR.
KEGG	rpt:Rpal_4750.
PATRIC	23314050. VBIRhoPal88240_4812.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_RHOPT

Accession

Primary (citable) accession number: B3Q6U2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 2, 2008
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program