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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Rhodopseudomonas palustris (strain TIE-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei243ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRPAL395960:G1GC6-3250-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Rpal_3252
OrganismiRhodopseudomonas palustris (strain TIE-1)
Taxonomic identifieri395960 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000900991 – 473Glutamate--tRNA ligaseAdd BLAST473

Proteomic databases

PRIDEiB3Q6P5

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB3Q6P5
SMRiB3Q6P5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 21"HIGH" regionUniRule annotationAdd BLAST11
Motifi240 – 244"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B3Q6P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRPVVTRFA PSPTGFLHIG GGRTALFNWL YARKHGGTML LRIEDTDRQR
60 70 80 90 100
STQEAIDAIL DGLKWLGIDW DGATVYQFAR AARHREVAEQ LLAAGKAYRC
110 120 130 140 150
YATAEELTAM RDKARAEGRA KLYDGSWRDR DPSEAPAGVK PTIRLKAPLT
160 170 180 190 200
GETVIEDQVQ GRVAWQNENL DDLVLLRGDG TPTYMLAVVV DDHDMGVTHV
210 220 230 240 250
IRGDDHLINA ARQKQIYDAM EWELPVMAHI PLIHGPDGSK LSKRHGALGV
260 270 280 290 300
DAYRAMGYLP AALRNYLVRL GWSHGDQEIF TTQEMIDAFD LPAIGRSAAR
310 320 330 340 350
FDFAKLESLN GHYIRQSDDH SLVTLLEDLL KYIPQGPAIA AKFDDSIRAK
360 370 380 390 400
LTQAMPGLKE RAKTLIELLD NAGFIFADRP LALDPKAQAV LTPETRQLIG
410 420 430 440 450
RLRAALEDVS PWTAATTEAA MRAFAEQAGL KLGAVAQPLR VALTGRTTSP
460 470
GIFDVLAVLG RDECLSRLAD QSA
Length:473
Mass (Da):52,105
Last modified:September 2, 2008 - v1
Checksum:i7A4225F5E3952E4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001096 Genomic DNA Translation: ACF01754.1
RefSeqiWP_012496350.1, NC_011004.1

Genome annotation databases

EnsemblBacteriaiACF01754; ACF01754; Rpal_3252
KEGGirpt:Rpal_3252

Entry informationi

Entry nameiSYE_RHOPT
AccessioniPrimary (citable) accession number: B3Q6P5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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