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Protein

Tryptophan synthase beta chain

Gene

trpB

Organism
Rhodopseudomonas palustris (strain TIE-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpBUniRule annotation
Ordered Locus Names:Rpal_0072
OrganismiRhodopseudomonas palustris (strain TIE-1)
Taxonomic identifieri395960 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000001725 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000958141 – 404Tryptophan synthase beta chainAdd BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei98N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB3Q605.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000161710.
KOiK01696.
OMAiEHSWLND.
OrthoDBiPOG091H02JY.

Family and domain databases

CDDicd06446. Trp-synth_B. 1 hit.
HAMAPiMF_00133. Trp_synth_beta. 1 hit.
InterProiIPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00263. trpB. 1 hit.
PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3Q605-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQALPNSFR SGPDERGHFG IYGGRFVAET LMPLILDLEK AYAEAKADPA
60 70 80 90 100
FRAEMDNHLK HYVGRPSALY FAERLTEHFG GAKIYFKRED LNHTGAHKVN
110 120 130 140 150
NVLGQIMLAK RMGKPRVIAE TGAGMHGVAT ATMCAKFGLE CVVFMGAVDV
160 170 180 190 200
ERQQPNVLRM KALGAEVRPV TSGANTLKDA MNEALRDWVT NVHDTFYCIG
210 220 230 240 250
TVAGPHPYPM MVRDFQAVIG QEVREQIMQA EGRLPDSLVA CIGGGSNAMG
260 270 280 290 300
LFHPFLDDPG VAIYGVEAAG HGLDKLHAAS IAGGKPGVLH GNRTYLLMDA
310 320 330 340 350
DGQIEEAHSI SAGLDYPGVG PEHSWLHDVG RVNFLSATDT EALDAFKLCC
360 370 380 390 400
RLEGIIPALE PSHALAKVAD LAPKLPKDHL MVVNMSGRGD KDLASVAEHL

GGKF
Length:404
Mass (Da):43,570
Last modified:September 2, 2008 - v1
Checksum:i861ADB30E2A49457
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001096 Genomic DNA. Translation: ACE98634.1.
RefSeqiWP_011155640.1. NC_011004.1.

Genome annotation databases

EnsemblBacteriaiACE98634; ACE98634; Rpal_0072.
KEGGirpt:Rpal_0072.
PATRICi23304480. VBIRhoPal88240_0073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001096 Genomic DNA. Translation: ACE98634.1.
RefSeqiWP_011155640.1. NC_011004.1.

3D structure databases

ProteinModelPortaliB3Q605.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACE98634; ACE98634; Rpal_0072.
KEGGirpt:Rpal_0072.
PATRICi23304480. VBIRhoPal88240_0073.

Phylogenomic databases

HOGENOMiHOG000161710.
KOiK01696.
OMAiEHSWLND.
OrthoDBiPOG091H02JY.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044.

Family and domain databases

CDDicd06446. Trp-synth_B. 1 hit.
HAMAPiMF_00133. Trp_synth_beta. 1 hit.
InterProiIPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00263. trpB. 1 hit.
PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRPB_RHOPT
AccessioniPrimary (citable) accession number: B3Q605
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: November 30, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.