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B3Q1Q5

- THIM_RHIE6

UniProt

B3Q1Q5 - THIM_RHIE6

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Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Rhizobium etli (strain CIAT 652)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371Substrate; via amide nitrogenUniRule annotation
Binding sitei112 – 1121ATPUniRule annotation
Binding sitei158 – 1581ATPUniRule annotation
Binding sitei185 – 1851Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-6202-MONOMER.
RETL491916:GH4T-6055-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
Short name:
TH kinaseUniRule annotation
Short name:
Thz kinaseUniRule annotation
Gene namesi
Name:thiMUniRule annotation
Ordered Locus Names:RHECIAT_PA0000267
Encoded oniPlasmid pA0 Publication
OrganismiRhizobium etli (strain CIAT 652)
Taxonomic identifieri491916 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000008817: Plasmid pA

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Hydroxyethylthiazole kinasePRO_0000383890Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi491916.RHECIAT_PA0000267.

Structurei

3D structure databases

ProteinModelPortaliB3Q1Q5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiQTFTANV.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00694. thiM. 1 hit.

Sequencei

Sequence statusi: Complete.

B3Q1Q5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLEAMREKPP LVHCITNYVA MNIAANVLLA SGASPAMVHA PEEAGEFAGI
60 70 80 90 100
ASALTVNIGT LSTQWLDGMR AAAKAAASSG KPWVLDPVAH YATAFRRQAV
110 120 130 140 150
ADLLALKPTI IRGNASEIIA LAGGESRGQG VDSRDPVEQA EDSARRLAER
160 170 180 190 200
QQAIVAVTGA VDFVTDGNRA VRIKGGSVLM PQVTALGCAL TCLVGAFAAT
210 220 230 240 250
APEDLFGATV AALATFAVAG EDAALGAAGP GSFAWRFLDA LAALDGEALD

ARARVSIA
Length:258
Mass (Da):26,320
Last modified:September 2, 2008 - v1
Checksum:iA50F611B8199D873
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001075 Genomic DNA. Translation: ACE93611.1.
RefSeqiYP_001985874.1. NC_010998.1.

Genome annotation databases

EnsemblBacteriaiACE93611; ACE93611; RHECIAT_PA0000267.
GeneIDi6404143.
KEGGirec:RHECIAT_PA0000267.
PATRICi23105580. VBIRhiEtl120572_5999.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001075 Genomic DNA. Translation: ACE93611.1 .
RefSeqi YP_001985874.1. NC_010998.1.

3D structure databases

ProteinModelPortali B3Q1Q5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 491916.RHECIAT_PA0000267.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACE93611 ; ACE93611 ; RHECIAT_PA0000267 .
GeneIDi 6404143.
KEGGi rec:RHECIAT_PA0000267.
PATRICi 23105580. VBIRhiEtl120572_5999.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi QTFTANV.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci RETL1328306-WGS:GSTH-6202-MONOMER.
RETL491916:GH4T-6055-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00694. thiM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome diversity and DNA divergence of Rhizobium etli."
    Gonzalez V., Acosta J.L., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.L., Fernandez J.L., Diaz R., Flores M., Mora J., Palacios R., Davila G.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CIAT 652.

Entry informationi

Entry nameiTHIM_RHIE6
AccessioniPrimary (citable) accession number: B3Q1Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 2, 2008
Last modified: October 1, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3