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B3PZ69

- DUT_RHIE6

UniProt

B3PZ69 - DUT_RHIE6

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

dut

Organism
Rhizobium etli (strain CIAT 652)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei89 – 891SubstrateUniRule annotation
    Binding sitei103 – 1031Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dUMP biosynthetic process Source: UniProtKB-UniPathway
    2. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-333-MONOMER.
    RETL491916:GH4T-369-MONOMER.
    UniPathwayiUPA00610; UER00666.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
    Short name:
    dUTPaseUniRule annotation
    Alternative name(s):
    dUTP pyrophosphataseUniRule annotation
    Gene namesi
    Name:dutUniRule annotation
    Ordered Locus Names:RHECIAT_CH0000369
    OrganismiRhizobium etli (strain CIAT 652)
    Taxonomic identifieri491916 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
    ProteomesiUP000008817: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 156156Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_1000094982Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi491916.RHECIAT_CH0000369.

    Structurei

    3D structure databases

    ProteinModelPortaliB3PZ69.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni76 – 783Substrate bindingUniRule annotation
    Regioni93 – 953Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the dUTPase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0756.
    HOGENOMiHOG000028966.
    KOiK01520.
    OMAiSIYIGDP.
    OrthoDBiEOG689HXK.

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    HAMAPiMF_00116. dUTPase_bact.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.
    TIGRFAMsiTIGR00576. dut. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B3PZ69-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTIHHETRPT LNLIRLANGE GLELPAYESQ GAAGMDLRAA VDGDAPLTLP    50
    PGKRALVPTG FIFEIPEGFE GQVRPRSGLA FKHGITCLNS PGTVDSDYRG 100
    EVKVLLANLG EEAFVIERGM RIAQMVIAPV TQARVAEITA ASETARGAGG 150
    FGSTGV 156
    Length:156
    Mass (Da):16,383
    Last modified:September 2, 2008 - v1
    Checksum:i0A6C6DA475EC2461
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001074 Genomic DNA. Translation: ACE89363.1.
    RefSeqiWP_012482379.1. NC_010994.1.
    YP_001976541.1. NC_010994.1.

    Genome annotation databases

    EnsemblBacteriaiACE89363; ACE89363; RHECIAT_CH0000369.
    GeneIDi6398243.
    KEGGirec:RHECIAT_CH0000369.
    PATRICi23094206. VBIRhiEtl120572_0370.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001074 Genomic DNA. Translation: ACE89363.1 .
    RefSeqi WP_012482379.1. NC_010994.1.
    YP_001976541.1. NC_010994.1.

    3D structure databases

    ProteinModelPortali B3PZ69.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 491916.RHECIAT_CH0000369.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACE89363 ; ACE89363 ; RHECIAT_CH0000369 .
    GeneIDi 6398243.
    KEGGi rec:RHECIAT_CH0000369.
    PATRICi 23094206. VBIRhiEtl120572_0370.

    Phylogenomic databases

    eggNOGi COG0756.
    HOGENOMi HOG000028966.
    KOi K01520.
    OMAi SIYIGDP.
    OrthoDBi EOG689HXK.

    Enzyme and pathway databases

    UniPathwayi UPA00610 ; UER00666 .
    BioCyci RETL1328306-WGS:GSTH-333-MONOMER.
    RETL491916:GH4T-369-MONOMER.

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    HAMAPi MF_00116. dUTPase_bact.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    TIGRFAMsi TIGR00576. dut. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome diversity and DNA divergence of Rhizobium etli."
      Gonzalez V., Acosta J.L., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.L., Fernandez J.L., Diaz R., Flores M., Mora J., Palacios R., Davila G.
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CIAT 652.

    Entry informationi

    Entry nameiDUT_RHIE6
    AccessioniPrimary (citable) accession number: B3PZ69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3