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B3PYJ1

- UPPP_RHIE6

UniProt

B3PYJ1 - UPPP_RHIE6

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Rhizobium etli (strain CIAT 652)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-314-MONOMER.
    RETL491916:GH4T-348-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:RHECIAT_CH0000348
    OrganismiRhizobium etli (strain CIAT 652)
    Taxonomic identifieri491916 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
    ProteomesiUP000008817: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 265265Undecaprenyl-diphosphatasePRO_1000197395Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi491916.RHECIAT_CH0000348.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5821HelicalUniRule annotationAdd
    BLAST
    Transmembranei80 – 10021HelicalUniRule annotationAdd
    BLAST
    Transmembranei107 – 12721HelicalUniRule annotationAdd
    BLAST
    Transmembranei135 – 15521HelicalUniRule annotationAdd
    BLAST
    Transmembranei175 – 19521HelicalUniRule annotationAdd
    BLAST
    Transmembranei213 – 23321HelicalUniRule annotationAdd
    BLAST
    Transmembranei244 – 26421HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiFNDAHAK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3PYJ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYINAALLG VIEGITEFLP ISSTGHLIIA EQWLGHRSDM FNIVIQAGAI    50
    LAVTIIYWRR LLDLVLGWRE PENRDYAAKL IVAFLITAIL GLVVKKLGFE 100
    LPETATPIAW ALIIGGIWMI FAEWAAARKA PHKEITWLVA ILVGIAQIVA 150
    GVFPGTSRSG ATIFVAMLAG TGNRAAATEF AFLVGIPTMY AASGYELLKT 200
    FKDGGAAGED WTALAIAFIV STIVAFIAVK WLLAYIRSNR FTLFAIYRII 250
    LGVLLLGMAT SGLIA 265
    Length:265
    Mass (Da):28,653
    Last modified:September 2, 2008 - v1
    Checksum:iB26C44D9A6953DEC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001074 Genomic DNA. Translation: ACE89342.1.
    RefSeqiYP_001976520.1. NC_010994.1.

    Genome annotation databases

    EnsemblBacteriaiACE89342; ACE89342; RHECIAT_CH0000348.
    GeneIDi6398222.
    KEGGirec:RHECIAT_CH0000348.
    PATRICi23094166. VBIRhiEtl120572_0350.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001074 Genomic DNA. Translation: ACE89342.1 .
    RefSeqi YP_001976520.1. NC_010994.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 491916.RHECIAT_CH0000348.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACE89342 ; ACE89342 ; RHECIAT_CH0000348 .
    GeneIDi 6398222.
    KEGGi rec:RHECIAT_CH0000348.
    PATRICi 23094166. VBIRhiEtl120572_0350.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi FNDAHAK.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci RETL1328306-WGS:GSTH-314-MONOMER.
    RETL491916:GH4T-348-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome diversity and DNA divergence of Rhizobium etli."
      Gonzalez V., Acosta J.L., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.L., Fernandez J.L., Diaz R., Flores M., Mora J., Palacios R., Davila G.
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CIAT 652.

    Entry informationi

    Entry nameiUPPP_RHIE6
    AccessioniPrimary (citable) accession number: B3PYJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3