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B3PYJ1

- UPPP_RHIE6

UniProt

B3PYJ1 - UPPP_RHIE6

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, RHECIAT_CH0000348
Organism
Rhizobium etli (strain CIAT 652)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-314-MONOMER.
RETL491916:GH4T-348-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:RHECIAT_CH0000348
OrganismiRhizobium etli (strain CIAT 652)
Taxonomic identifieri491916 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000008817: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei38 – 5821Helical; Reviewed prediction
Add
BLAST
Transmembranei80 – 10021Helical; Reviewed prediction
Add
BLAST
Transmembranei107 – 12721Helical; Reviewed prediction
Add
BLAST
Transmembranei135 – 15521Helical; Reviewed prediction
Add
BLAST
Transmembranei175 – 19521Helical; Reviewed prediction
Add
BLAST
Transmembranei213 – 23321Helical; Reviewed prediction
Add
BLAST
Transmembranei244 – 26421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Undecaprenyl-diphosphataseUniRule annotation
PRO_1000197395Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi491916.RHECIAT_CH0000348.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3PYJ1-1 [UniParc]FASTAAdd to Basket

« Hide

MDYINAALLG VIEGITEFLP ISSTGHLIIA EQWLGHRSDM FNIVIQAGAI    50
LAVTIIYWRR LLDLVLGWRE PENRDYAAKL IVAFLITAIL GLVVKKLGFE 100
LPETATPIAW ALIIGGIWMI FAEWAAARKA PHKEITWLVA ILVGIAQIVA 150
GVFPGTSRSG ATIFVAMLAG TGNRAAATEF AFLVGIPTMY AASGYELLKT 200
FKDGGAAGED WTALAIAFIV STIVAFIAVK WLLAYIRSNR FTLFAIYRII 250
LGVLLLGMAT SGLIA 265
Length:265
Mass (Da):28,653
Last modified:September 2, 2008 - v1
Checksum:iB26C44D9A6953DEC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001074 Genomic DNA. Translation: ACE89342.1.
RefSeqiYP_001976520.1. NC_010994.1.

Genome annotation databases

EnsemblBacteriaiACE89342; ACE89342; RHECIAT_CH0000348.
GeneIDi6398222.
KEGGirec:RHECIAT_CH0000348.
PATRICi23094166. VBIRhiEtl120572_0350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001074 Genomic DNA. Translation: ACE89342.1 .
RefSeqi YP_001976520.1. NC_010994.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 491916.RHECIAT_CH0000348.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACE89342 ; ACE89342 ; RHECIAT_CH0000348 .
GeneIDi 6398222.
KEGGi rec:RHECIAT_CH0000348.
PATRICi 23094166. VBIRhiEtl120572_0350.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-314-MONOMER.
RETL491916:GH4T-348-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome diversity and DNA divergence of Rhizobium etli."
    Gonzalez V., Acosta J.L., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.L., Fernandez J.L., Diaz R., Flores M., Mora J., Palacios R., Davila G.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CIAT 652.

Entry informationi

Entry nameiUPPP_RHIE6
AccessioniPrimary (citable) accession number: B3PYJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: July 9, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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