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Protein

Aminopyrimidine aminohydrolase

Gene

RHECIAT_CH0000284

Organism
Rhizobium etli (strain CIAT 652)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.UniRule annotation

Catalytic activityi

4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + ammonia.UniRule annotation
Thiamine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole.UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in the pathway thiamine diphosphate biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processThiamine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00060

Names & Taxonomyi

Protein namesi
Recommended name:
Aminopyrimidine aminohydrolaseUniRule annotation (EC:3.5.99.2UniRule annotation)
Gene namesi
Ordered Locus Names:RHECIAT_CH0000284Imported
OrganismiRhizobium etli (strain CIAT 652)Imported
Taxonomic identifieri491916 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000008817 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi491916.RHECIAT_CH0000284

Structurei

3D structure databases

ProteinModelPortaliB3PYC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 226TENA_THI-4InterPro annotationAdd BLAST208

Sequence similaritiesi

Belongs to the TenA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105ETU Bacteria
COG0819 LUCA
HOGENOMiHOG000225158
KOiK03707
OMAiCISHPFV
OrthoDBiPOG091H07EO

Family and domain databases

Gene3Di1.20.910.10, 1 hit
InterProiView protein in InterPro
IPR016084 Haem_Oase-like_multi-hlx
IPR004305 Thiaminase-2/PQQC
IPR027574 Thiaminase_II
PfamiView protein in Pfam
PF03070 TENA_THI-4, 1 hit
SUPFAMiSSF48613 SSF48613, 1 hit
TIGRFAMsiTIGR04306 salvage_TenA, 1 hit

Sequencei

Sequence statusi: Complete.

B3PYC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDASTQSTEL TGSFTAAAWD RIAPIMAEIE ALPLLTRLSD GTLPPEIFRH
60 70 80 90 100
YILQDALYLK HYARCLAIVA AKAPDNAQVL RFLGSAQKAI TVEQGLHAGF
110 120 130 140 150
LTQFGITAAD LTSAEPSPTC FAYTNFLLAT AYHRSYAVAL SAILPCFWIY
160 170 180 190 200
WHVGEAIKNQ PVVEGNAFQA WINTYGDPQF AAGAREVIAL TDIAARAASP
210 220 230
AERTEMTDAF VRASQYEWMF WDSAWRLETW PV
Length:232
Mass (Da):25,641
Last modified:September 2, 2008 - v1
Checksum:i56BB5638B58BAC47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001074 Genomic DNA Translation: ACE89278.1
RefSeqiWP_012482303.1, NC_010994.1

Genome annotation databases

EnsemblBacteriaiACE89278; ACE89278; RHECIAT_CH0000284
KEGGirec:RHECIAT_CH0000284

Similar proteinsi

Entry informationi

Entry nameiB3PYC7_RHIE6
AccessioniPrimary (citable) accession number: B3PYC7
Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: May 23, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health