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Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Rhizobium etli (strain CIAT 652)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Fe cationUniRule annotation

Pathwayi: L-phenylalanine degradation

This protein is involved in step 4 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Homogentisate 1,2-dioxygenase (hmgA)
  5. no protein annotated in this organism
  6. no protein annotated in this organism
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei306Proton acceptorUniRule annotation1
Metal bindingi349IronUniRule annotation1
Metal bindingi355IronUniRule annotation1
Binding sitei364homogentisateUniRule annotation1
Metal bindingi385IronUniRule annotation1
Binding sitei385homogentisateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processPhenylalanine catabolism, Tyrosine catabolism
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciRETL491916:G1GBZ-1809-MONOMER
UniPathwayiUPA00139; UER00339

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
Short name:
HGDOUniRule annotation
Alternative name(s):
Homogentisate oxygenaseUniRule annotation
Homogentisic acid oxidaseUniRule annotation
HomogentisicaseUniRule annotation
Gene namesi
Name:hmgAUniRule annotation
Ordered Locus Names:RHECIAT_CH0001827
OrganismiRhizobium etli (strain CIAT 652)
Taxonomic identifieri491916 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000008817 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001198481 – 453Homogentisate 1,2-dioxygenaseAdd BLAST453

Interactioni

Subunit structurei

Hexamer; dimer of trimers.UniRule annotation

Protein-protein interaction databases

STRINGi491916.RHECIAT_CH0001827

Structurei

3D structure databases

SMRiB3PWZ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F1J Bacteria
COG3508 LUCA
HOGENOMiHOG000139824
KOiK00451
OMAiHGNYTPY
OrthoDBiPOG091H04E0

Family and domain databases

Gene3Di2.60.120.10, 1 hit
HAMAPiMF_00334 Homogentis_dioxygen, 1 hit
InterProiView protein in InterPro
IPR005708 Homogentis_dOase
IPR022950 Homogentis_dOase_bac
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR11056 PTHR11056, 1 hit
PfamiView protein in Pfam
PF04209 HgmA, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit
TIGRFAMsiTIGR01015 hmgA, 1 hit

Sequencei

Sequence statusi: Complete.

B3PWZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQTSIQASS GDAAAADQLK YMPGFGNDFE TESLPGALPQ GQNSPQKCNY
60 70 80 90 100
GLYAEQLSGS PFTAPRGTNE RSWLYRIRPS VRHTRRFSNA SYPLWKTAPC
110 120 130 140 150
LDEHSLPLGQ LRWDPIPPPE ERLNFLEGVR TITTAGDATT QVGMSAHAYV
160 170 180 190 200
FNEDMVDDYF FNADGELLIV PQLGALRVFT EMGIMDVEPS EICLVPRGMM
210 220 230 240 250
FKILTSGKQT AWRGYICENY GAKFTLPERG PIGANCLANP RDFKTPVAAY
260 270 280 290 300
EDKEKPCRVH VKWCGKFYVT EIGHSPLDVV AWHGNYAPFK YDLRTFSPVG
310 320 330 340 350
AILFDHPDPS IFSVLTAPTE DAGTANVDFV IFPPRWLVAE HTFRPPWYHR
360 370 380 390 400
NIMSEFMGLI HGQYDAKEEG FVPGGMSLHN MMLPHGPDAL AFEKAANAEL
410 420 430 440 450
KPVKLDHTMA FMFETRYPQQ LTKYAAELET LQDDYLECWD GLERKFDGNP

GIK
Length:453
Mass (Da):50,885
Last modified:September 2, 2008 - v1
Checksum:i1FAC7603E7244E21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001074 Genomic DNA Translation: ACE90797.1
RefSeqiWP_012483531.1, NC_010994.1

Genome annotation databases

EnsemblBacteriaiACE90797; ACE90797; RHECIAT_CH0001827
KEGGirec:RHECIAT_CH0001827

Similar proteinsi

Entry informationi

Entry nameiHGD_RHIE6
AccessioniPrimary (citable) accession number: B3PWZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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