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Protein

Arginine deiminase

Gene

arcA

Organism
Rhizobium etli (strain CIAT 652)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-arginine + H2O = L-citrulline + NH3.UniRule annotation

Pathwayi: L-arginine degradation via ADI pathway

This protein is involved in step 1 of the subpathway that synthesizes carbamoyl phosphate from L-arginine.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Arginine deiminase (arcA)
  2. Ornithine carbamoyltransferase, catabolic (argF), Ornithine carbamoyltransferase, catabolic (arcB)
This subpathway is part of the pathway L-arginine degradation via ADI pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes carbamoyl phosphate from L-arginine, the pathway L-arginine degradation via ADI pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei398 – 3981Amidino-cysteine intermediateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Arginine metabolism

Enzyme and pathway databases

BioCyciRETL491916:GH4T-128-MONOMER.
UniPathwayiUPA00254; UER00364.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine deiminaseUniRule annotation (EC:3.5.3.6UniRule annotation)
Short name:
ADIUniRule annotation
Alternative name(s):
Arginine dihydrolaseUniRule annotation
Short name:
ADUniRule annotation
Gene namesi
Name:arcAUniRule annotation
Ordered Locus Names:RHECIAT_CH0000128
OrganismiRhizobium etli (strain CIAT 652)
Taxonomic identifieri491916 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000008817 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Arginine deiminasePRO_1000100742Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi491916.RHECIAT_CH0000128.

Structurei

3D structure databases

ProteinModelPortaliB3PWQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginine deiminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEU. Bacteria.
COG2235. LUCA.
HOGENOMiHOG000284536.
KOiK01478.
OMAiDVLEMHN.
OrthoDBiPOG091H06H4.

Family and domain databases

HAMAPiMF_00242. Arg_deiminase. 1 hit.
InterProiIPR003876. Arg_deiminase.
IPR033199. DDAH/AD.
[Graphical view]
PANTHERiPTHR12737. PTHR12737. 3 hits.
PIRSFiPIRSF006356. Arg_deiminase. 1 hit.
PRINTSiPR01466. ARGDEIMINASE.
TIGRFAMsiTIGR01078. arcA. 1 hit.

Sequencei

Sequence statusi: Complete.

B3PWQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGFGVHSEV GKLRTVMVCR PSLAHQRLTP ANCHDLLFDD VLWVHEAQKD
60 70 80 90 100
HFDFVLKMQE RGVEVLELHD LLGQTLANQQ ARDFLLDRRI TPNVLGSQIA
110 120 130 140 150
EAMRPWLDEM PAAQLAAFMI GGIAISDLPE VRAKSLMLSA LPETDFVIPP
160 170 180 190 200
IPNTLFQRDP SCWIYGGVTC NPMFWPARRA ETLIQRAIYK FHPIFLGGDF
210 220 230 240 250
QIWWGDSDQP FANASMEGGD VMPIGNGTVL IGMGERTTYQ AVGQVAQALF
260 270 280 290 300
RSKAAKRVIG CLMPKSRAAM HLDTVFSFCD RDVVTLFAEV VDQVRCYSMY
310 320 330 340 350
PKDDDGTFEI HPENRPMLDV VAEALDLPQL RTVETGGNSY QAEREQWDDG
360 370 380 390 400
NNVVALEPGV VVAYDRNTYT NTLLRKAGIE VITIRGSELG RGRGGGHCMT

CPIWRDPAY
Length:409
Mass (Da):45,712
Last modified:September 2, 2008 - v1
Checksum:i920A434DA72A3B3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001074 Genomic DNA. Translation: ACE89124.1.
RefSeqiWP_012482189.1. NC_010994.1.

Genome annotation databases

EnsemblBacteriaiACE89124; ACE89124; RHECIAT_CH0000128.
KEGGirec:RHECIAT_CH0000128.
PATRICi23093718. VBIRhiEtl120572_0128.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001074 Genomic DNA. Translation: ACE89124.1.
RefSeqiWP_012482189.1. NC_010994.1.

3D structure databases

ProteinModelPortaliB3PWQ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi491916.RHECIAT_CH0000128.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACE89124; ACE89124; RHECIAT_CH0000128.
KEGGirec:RHECIAT_CH0000128.
PATRICi23093718. VBIRhiEtl120572_0128.

Phylogenomic databases

eggNOGiENOG4105CEU. Bacteria.
COG2235. LUCA.
HOGENOMiHOG000284536.
KOiK01478.
OMAiDVLEMHN.
OrthoDBiPOG091H06H4.

Enzyme and pathway databases

UniPathwayiUPA00254; UER00364.
BioCyciRETL491916:GH4T-128-MONOMER.

Family and domain databases

HAMAPiMF_00242. Arg_deiminase. 1 hit.
InterProiIPR003876. Arg_deiminase.
IPR033199. DDAH/AD.
[Graphical view]
PANTHERiPTHR12737. PTHR12737. 3 hits.
PIRSFiPIRSF006356. Arg_deiminase. 1 hit.
PRINTSiPR01466. ARGDEIMINASE.
TIGRFAMsiTIGR01078. arcA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARCA_RHIE6
AccessioniPrimary (citable) accession number: B3PWQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: September 7, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.