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B3PWJ0

- MASZ_RHIE6

UniProt

B3PWJ0 - MASZ_RHIE6

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Protein

Malate synthase G

Gene
glcB, RHECIAT_CH0000055
Organism
Rhizobium etli (strain CIAT 652)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161Acetyl-CoA; via carbonyl oxygen By similarity
Binding sitei274 – 2741Acetyl-CoA By similarity
Binding sitei311 – 3111Acetyl-CoA By similarity
Active sitei338 – 3381Proton acceptor By similarity
Binding sitei338 – 3381Glyoxylate By similarity
Metal bindingi430 – 4301Magnesium By similarity
Binding sitei430 – 4301Glyoxylate By similarity
Metal bindingi458 – 4581Magnesium By similarity
Binding sitei539 – 5391Acetyl-CoA; via carbonyl oxygen By similarity
Active sitei629 – 6291Proton donor By similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-53-MONOMER.
RETL491916:GH4T-55-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase G (EC:2.3.3.9)
Gene namesi
Name:glcB
Ordered Locus Names:RHECIAT_CH0000055
OrganismiRhizobium etli (strain CIAT 652)
Taxonomic identifieri491916 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000008817: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 723723Malate synthase GUniRule annotationPRO_1000130895Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei615 – 6151Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi491916.RHECIAT_CH0000055.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni123 – 1242Acetyl-CoA binding By similarity
Regioni455 – 4584Glyoxylate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSQFIENE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

B3PWJ0-1 [UniParc]FASTAAdd to Basket

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MSRIDKNGLA VEAVLHDFLV QEVLPGLAID ADKFFADFSA IVHDLAPINR    50
ALLKKRDELQ LKIDDWYRQH GAPTDMDDYQ SFLRAIGYLL PEGSDFQVST 100
QNVDPEIASI AGPQLVVPVM NARYALNAAN ARWGSLYDAL YGTDAIPEGD 150
GAEKGRGYNP KRGEKVIAWV RDFLDTSVPL QDSRWKDVGS FAVRDGALII 200
RSTDGEQAML RDGGHFAGYR GDAATPTHIL LKNNGIHIEI VIDAATAIGK 250
TDPAHISDVW LESAITTIMD CEDSIAAVDA EDKVVVYRNW LGLMKGDLQE 300
EVAKGGASFI RKLNPDLDYT GPDGTTFELH RRSLMLVRNV GHLMTNPAIL 350
DRDGNEVPEG IMDAVITGLI ALYDIGPAGR KKNSRTGSMY VVKPKMHGPE 400
EVAFAVEVFS RVEDALGLAR NTIKMGIMDE ERRTTVNLKE CIRAARERVV 450
FINTGFLDRT GDEIHTSMEA GPMIRKGDMR QAAWISAYEN WNVDIGLECG 500
LAGHAQIGKG MWAMPDLMAA MLEQKIAHPK AGANTAWVPS PTAATLHATH 550
YHRVNVAKVQ QGLKDRARAK LSDILSVPVA VRPNWSQEEI QRELDNNAQG 600
ILGYVVRWVD QGVGCSKVPD INNIGLMEDR ATLRISAQHM ANWLHHKVVS 650
EAQIVETMKR MAAVVDRQNE QDPVYQPISG NFDGSIAFQA ALDLVLKGRE 700
QPNGYTEPVL HRRRLELKAK QAA 723
Length:723
Mass (Da):79,766
Last modified:September 2, 2008 - v1
Checksum:iDD5FC50622E412E6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001074 Genomic DNA. Translation: ACE89058.1.
RefSeqiWP_012482126.1. NC_010994.1.
YP_001976236.1. NC_010994.1.

Genome annotation databases

EnsemblBacteriaiACE89058; ACE89058; RHECIAT_CH0000055.
GeneIDi6398354.
KEGGirec:RHECIAT_CH0000055.
PATRICi23093564. VBIRhiEtl120572_0058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001074 Genomic DNA. Translation: ACE89058.1 .
RefSeqi WP_012482126.1. NC_010994.1.
YP_001976236.1. NC_010994.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 491916.RHECIAT_CH0000055.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACE89058 ; ACE89058 ; RHECIAT_CH0000055 .
GeneIDi 6398354.
KEGGi rec:RHECIAT_CH0000055.
PATRICi 23093564. VBIRhiEtl120572_0058.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi SQFIENE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci RETL1328306-WGS:GSTH-53-MONOMER.
RETL491916:GH4T-55-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome diversity and DNA divergence of Rhizobium etli."
    Gonzalez V., Acosta J.L., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.L., Fernandez J.L., Diaz R., Flores M., Mora J., Palacios R., Davila G.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CIAT 652.

Entry informationi

Entry nameiMASZ_RHIE6
AccessioniPrimary (citable) accession number: B3PWJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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