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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Rhizobium etli (strain CIAT 652)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciRETL491916:G1GBZ-21-MONOMER
UniPathwayiUPA00035; UER00042

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation (EC:5.3.1.24UniRule annotation)
Short name:
PRAIUniRule annotation
Gene namesi
Name:trpFUniRule annotation
Ordered Locus Names:RHECIAT_CH0000021
OrganismiRhizobium etli (strain CIAT 652)
Taxonomic identifieri491916 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000008817 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000959341 – 222N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST222

Interactioni

Protein-protein interaction databases

STRINGi491916.RHECIAT_CH0000021

Structurei

3D structure databases

ProteinModelPortaliB3PVV1
SMRiB3PVV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZGB Bacteria
COG0135 LUCA
HOGENOMiHOG000161598
KOiK01817
OMAiFYAKSPR
OrthoDBiPOG091H01PA

Family and domain databases

CDDicd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00697 PRAI, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit

Sequencei

Sequence statusi: Complete.

B3PVV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPDIKICGL KTPEAIDRAL KRGATHIGFI FFEKSPRYIE PDLAAKLAEP
60 70 80 90 100
ARGKAKIVAV VVDPTNDELD EIVSLLKPDI LQLHGNESPE HVLTIKALYG
110 120 130 140 150
LPVMKVFSVR TAADLKRVEA YIGIADRFLF DAKAPKGSEL PGGNGISFDW
160 170 180 190 200
SLLSWLDGSI DYMLSGGLNK DNVANALANT TARGIDVSSG VESAPGVKSV
210 220
AMIDEFFDAV EGADAPVMAS GS
Length:222
Mass (Da):23,683
Last modified:September 2, 2008 - v1
Checksum:i1D03FFBB26EC2D65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001074 Genomic DNA Translation: ACE89024.1
RefSeqiWP_012482099.1, NC_010994.1

Genome annotation databases

EnsemblBacteriaiACE89024; ACE89024; RHECIAT_CH0000021
KEGGirec:RHECIAT_CH0000021

Similar proteinsi

Entry informationi

Entry nameiTRPF_RHIE6
AccessioniPrimary (citable) accession number: B3PVV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: April 25, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health