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B3PUJ1

- B3PUJ1_RHIE6

UniProt

B3PUJ1 - B3PUJ1_RHIE6

Protein

Carbamoyl-phosphate synthase small chain

Gene

carA

Organism
Rhizobium etli (strain CIAT 652)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei284 – 2841NucleophileUniRule annotation
    Active sitei368 – 3681UniRule annotation
    Active sitei370 – 3701UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
    2. arginine biosynthetic process Source: UniProtKB-HAMAP
    3. carbamoyl phosphate biosynthetic process Source: InterPro
    4. glutamine catabolic process Source: InterPro

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation, Pyrimidine biosynthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRETL491916:GH4T-3123-MONOMER.
    UniPathwayiUPA00068; UER00171.
    UPA00070; UER00115.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carbamoyl-phosphate synthase small chainUniRule annotation (EC:6.3.5.5UniRule annotation)
    Alternative name(s):
    Carbamoyl-phosphate synthetase glutamine chainUniRule annotation
    Gene namesi
    Name:carAUniRule annotationImported
    Ordered Locus Names:RHECIAT_CH0003124Imported
    OrganismiRhizobium etli (strain CIAT 652)Imported
    Taxonomic identifieri491916 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
    ProteomesiUP000008817: Chromosome

    Interactioni

    Subunit structurei

    Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.UniRule annotation

    Protein-protein interaction databases

    STRINGi491916.RHECIAT_CH0003124.

    Structurei

    3D structure databases

    ProteinModelPortaliB3PUJ1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini207 – 395189Glutamine amidotransferase type-1UniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 203203CPSaseUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CarA family.UniRule annotation
    Contains 1 glutamine amidotransferase type-1 domain.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferaseUniRule annotation

    Phylogenomic databases

    eggNOGiCOG0505.
    HOGENOMiHOG000038087.
    KOiK01956.
    OMAiKTIKMKF.
    OrthoDBiEOG61ZTH6.

    Family and domain databases

    Gene3Di3.40.50.880. 1 hit.
    3.50.30.20. 1 hit.
    HAMAPiMF_01209. CPSase_S_chain.
    InterProiIPR006274. CarbamoylP_synth_ssu.
    IPR002474. CarbamoylP_synth_ssu_N.
    IPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    [Graphical view]
    PfamiPF00988. CPSase_sm_chain. 1 hit.
    PF00117. GATase. 1 hit.
    [Graphical view]
    SMARTiSM01097. CPSase_sm_chain. 1 hit.
    [Graphical view]
    SUPFAMiSSF52021. SSF52021. 1 hit.
    SSF52317. SSF52317. 1 hit.
    TIGRFAMsiTIGR01368. CPSaseIIsmall. 1 hit.
    PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3PUJ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTATAPWTIE KPTALLVLAD GTVIEGKGIG ATGKIQAEVV FNTALTGYEE    50
    IMTDPSYLGQ IVTFTFPHIG NIGTNDEDIE DLTPAARHGA VGVIFKADIT 100
    EPSNYRAAKH LDQWLKARGI IGLCGIDTRA LTAWIRENGA PNAVIAHDPN 150
    GVFDIETLKA EAKAWSGLEG LDLAKIATSG QSSQWTQTPW IWNEGYGELG 200
    AADAKYHVVC LDYGVKRNIL RLFAGLDCKV TVVPATTSAE DVLAMQPDGI 250
    FLSNGPGDPA ATGEYAVPVI KTLVKTDIPV FGICLGHQML GLALGAKTEK 300
    MHQGHHGANH PVKDHTTGKV EIVSMNHGFA VDSKSLPDGV EETHISLFDG 350
    TNCGLRVLGK QVFSVQHHPE ASPGPQDSHY LFRRFINMVR EKKGEPALAE 400
    R 401
    Length:401
    Mass (Da):43,085
    Last modified:September 2, 2008 - v1
    Checksum:i1BA1D43077DFC716
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001074 Genomic DNA. Translation: ACE92072.1.
    RefSeqiYP_001979250.1. NC_010994.1.

    Genome annotation databases

    EnsemblBacteriaiACE92072; ACE92072; RHECIAT_CH0003124.
    GeneIDi6401211.
    KEGGirec:RHECIAT_CH0003124.
    PATRICi23099738. VBIRhiEtl120572_3100.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001074 Genomic DNA. Translation: ACE92072.1 .
    RefSeqi YP_001979250.1. NC_010994.1.

    3D structure databases

    ProteinModelPortali B3PUJ1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 491916.RHECIAT_CH0003124.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACE92072 ; ACE92072 ; RHECIAT_CH0003124 .
    GeneIDi 6401211.
    KEGGi rec:RHECIAT_CH0003124.
    PATRICi 23099738. VBIRhiEtl120572_3100.

    Phylogenomic databases

    eggNOGi COG0505.
    HOGENOMi HOG000038087.
    KOi K01956.
    OMAi KTIKMKF.
    OrthoDBi EOG61ZTH6.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00171 .
    UPA00070 ; UER00115 .
    BioCyci RETL491916:GH4T-3123-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.880. 1 hit.
    3.50.30.20. 1 hit.
    HAMAPi MF_01209. CPSase_S_chain.
    InterProi IPR006274. CarbamoylP_synth_ssu.
    IPR002474. CarbamoylP_synth_ssu_N.
    IPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    [Graphical view ]
    Pfami PF00988. CPSase_sm_chain. 1 hit.
    PF00117. GATase. 1 hit.
    [Graphical view ]
    SMARTi SM01097. CPSase_sm_chain. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52021. SSF52021. 1 hit.
    SSF52317. SSF52317. 1 hit.
    TIGRFAMsi TIGR01368. CPSaseIIsmall. 1 hit.
    PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome diversity and DNA divergence of Rhizobium etli."
      Gonzalez V., Acosta J.L., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.L., Fernandez J.L., Diaz R., Flores M., Mora J., Palacios R., Davila G.
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CIAT 652Imported.

    Entry informationi

    Entry nameiB3PUJ1_RHIE6
    AccessioniPrimary (citable) accession number: B3PUJ1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 2, 2008
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3