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B3PUJ1

- B3PUJ1_RHIE6

UniProt

B3PUJ1 - B3PUJ1_RHIE6

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Protein

Carbamoyl-phosphate synthase small chain

Gene

carA

Organism
Rhizobium etli (strain CIAT 652)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei284 – 2841NucleophileUniRule annotation
Active sitei368 – 3681UniRule annotation
Active sitei370 – 3701UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. arginine biosynthetic process Source: UniProtKB-HAMAP
  3. carbamoyl phosphate biosynthetic process Source: InterPro
  4. glutamine catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation, Pyrimidine biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciRETL491916:GH4T-3123-MONOMER.
UniPathwayiUPA00068; UER00171.
UPA00070; UER00115.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbamoyl-phosphate synthase small chainUniRule annotation (EC:6.3.5.5UniRule annotation)
Alternative name(s):
Carbamoyl-phosphate synthetase glutamine chainUniRule annotation
Gene namesi
Name:carAUniRule annotationImported
Ordered Locus Names:RHECIAT_CH0003124Imported
OrganismiRhizobium etli (strain CIAT 652)Imported
Taxonomic identifieri491916 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000008817: Chromosome

Interactioni

Subunit structurei

Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.UniRule annotation

Protein-protein interaction databases

STRINGi491916.RHECIAT_CH0003124.

Structurei

3D structure databases

ProteinModelPortaliB3PUJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini207 – 395189Glutamine amidotransferase type-1UniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 203203CPSaseUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CarA family.UniRule annotation
Contains 1 glutamine amidotransferase type-1 domain.UniRule annotation

Keywords - Domaini

Glutamine amidotransferaseUniRule annotation

Phylogenomic databases

eggNOGiCOG0505.
HOGENOMiHOG000038087.
KOiK01956.
OMAiKTIKMKF.
OrthoDBiEOG61ZTH6.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
3.50.30.20. 1 hit.
HAMAPiMF_01209. CPSase_S_chain.
InterProiIPR006274. CarbamoylP_synth_ssu.
IPR002474. CarbamoylP_synth_ssu_N.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
[Graphical view]
PfamiPF00988. CPSase_sm_chain. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SMARTiSM01097. CPSase_sm_chain. 1 hit.
[Graphical view]
SUPFAMiSSF52021. SSF52021. 1 hit.
SSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR01368. CPSaseIIsmall. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3PUJ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTATAPWTIE KPTALLVLAD GTVIEGKGIG ATGKIQAEVV FNTALTGYEE
60 70 80 90 100
IMTDPSYLGQ IVTFTFPHIG NIGTNDEDIE DLTPAARHGA VGVIFKADIT
110 120 130 140 150
EPSNYRAAKH LDQWLKARGI IGLCGIDTRA LTAWIRENGA PNAVIAHDPN
160 170 180 190 200
GVFDIETLKA EAKAWSGLEG LDLAKIATSG QSSQWTQTPW IWNEGYGELG
210 220 230 240 250
AADAKYHVVC LDYGVKRNIL RLFAGLDCKV TVVPATTSAE DVLAMQPDGI
260 270 280 290 300
FLSNGPGDPA ATGEYAVPVI KTLVKTDIPV FGICLGHQML GLALGAKTEK
310 320 330 340 350
MHQGHHGANH PVKDHTTGKV EIVSMNHGFA VDSKSLPDGV EETHISLFDG
360 370 380 390 400
TNCGLRVLGK QVFSVQHHPE ASPGPQDSHY LFRRFINMVR EKKGEPALAE

R
Length:401
Mass (Da):43,085
Last modified:September 2, 2008 - v1
Checksum:i1BA1D43077DFC716
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001074 Genomic DNA. Translation: ACE92072.1.
RefSeqiYP_001979250.1. NC_010994.1.

Genome annotation databases

EnsemblBacteriaiACE92072; ACE92072; RHECIAT_CH0003124.
GeneIDi6401211.
KEGGirec:RHECIAT_CH0003124.
PATRICi23099738. VBIRhiEtl120572_3100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001074 Genomic DNA. Translation: ACE92072.1 .
RefSeqi YP_001979250.1. NC_010994.1.

3D structure databases

ProteinModelPortali B3PUJ1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 491916.RHECIAT_CH0003124.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACE92072 ; ACE92072 ; RHECIAT_CH0003124 .
GeneIDi 6401211.
KEGGi rec:RHECIAT_CH0003124.
PATRICi 23099738. VBIRhiEtl120572_3100.

Phylogenomic databases

eggNOGi COG0505.
HOGENOMi HOG000038087.
KOi K01956.
OMAi KTIKMKF.
OrthoDBi EOG61ZTH6.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00171 .
UPA00070 ; UER00115 .
BioCyci RETL491916:GH4T-3123-MONOMER.

Family and domain databases

Gene3Di 3.40.50.880. 1 hit.
3.50.30.20. 1 hit.
HAMAPi MF_01209. CPSase_S_chain.
InterProi IPR006274. CarbamoylP_synth_ssu.
IPR002474. CarbamoylP_synth_ssu_N.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
[Graphical view ]
Pfami PF00988. CPSase_sm_chain. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view ]
SMARTi SM01097. CPSase_sm_chain. 1 hit.
[Graphical view ]
SUPFAMi SSF52021. SSF52021. 1 hit.
SSF52317. SSF52317. 1 hit.
TIGRFAMsi TIGR01368. CPSaseIIsmall. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome diversity and DNA divergence of Rhizobium etli."
    Gonzalez V., Acosta J.L., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.L., Fernandez J.L., Diaz R., Flores M., Mora J., Palacios R., Davila G.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CIAT 652Imported.

Entry informationi

Entry nameiB3PUJ1_RHIE6
AccessioniPrimary (citable) accession number: B3PUJ1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3