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Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Rhizobium etli (strain CIAT 652)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

K+UniRule annotationNote: Binds 2 potassium ions per subunit.UniRule annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine from betaine aldehyde.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. NAD/NADP-dependent betaine aldehyde dehydrogenase (betB)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine from betaine aldehyde, the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi26Potassium 1UniRule annotation1
Metal bindingi93Potassium 1UniRule annotation1
Active sitei162Charge relay systemUniRule annotation1
Metal bindingi244Potassium 2; via carbonyl oxygenUniRule annotation1
Active sitei250Proton acceptorUniRule annotation1
Binding sitei284NAD/NADPUniRule annotation1
Binding sitei384NAD/NADPUniRule annotation1
Metal bindingi454Potassium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi457Potassium 2; via carbonyl oxygenUniRule annotation1
Active sitei461Charge relay systemUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi150 – 153NAD/NADPUniRule annotation4
Nucleotide bindingi176 – 179NAD/NADPUniRule annotation4
Nucleotide bindingi228 – 233NAD/NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betBUniRule annotation
Ordered Locus Names:RHECIAT_CH0001220
OrganismiRhizobium etli (strain CIAT 652)
Taxonomic identifieri491916 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000008817 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001339571 – 487NAD/NADP-dependent betaine aldehyde dehydrogenaseAdd BLAST487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei284Cysteine sulfenic acid (-SOH)UniRule annotation1

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi491916.RHECIAT_CH0001220

Structurei

3D structure databases

ProteinModelPortaliB3PTE1
SMRiB3PTE1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C26 Bacteria
COG1012 LUCA
HOGENOMiHOG000271505
KOiK00130
OMAiSFGYTRR
OrthoDBiPOG091H05FS

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
HAMAPiMF_00804 BADH, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR011264 BADH
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR01804 BADH, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

B3PTE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAQPKASHF IDGEYVEDSD GTVIESLYPA TGEVIARLHA ATPAIVEKAI
60 70 80 90 100
AAAKSAQPEW AAMSPMARGR ILKRAADIMR ERNRELSELE TLDTGKPIQE
110 120 130 140 150
TIVADPTSGA DAFEFFGGVA PAGLNGSHIP LGQDFAYTKR VPLGVCVGIG
160 170 180 190 200
AWNYPQQIAC WKGAPALIAG NAMVFKPSEN TPLGALKIAE ILHEAGLPKG
210 220 230 240 250
LFNVIQGDRD TGPLLVNHPD VAKVSLTGSV PTGRRVAAAA AGSLKHVTME
260 270 280 290 300
LGGKSPLIVF DDADLDSAVG GAMLGNFYST GQVCSNGTRV FVQKGIKTEF
310 320 330 340 350
LKRLKARTEA MLIGDPMDEA TQIGPMVSWA QREKVVAYIE KGKAEGATLV
360 370 380 390 400
AGGGIPNNVS GEGYYVQPTV FADVTDEMTI AREEIFGPVM SVLDFDDEDE
410 420 430 440 450
VITRANASEF GLSGGVFTAD LTRAHRVVDR LEAGTLWINA YNLAPVEIPF
460 470 480
GGSKQSGFGR ENSLAALEHY SELKTVYVGM GPVQAPY
Length:487
Mass (Da):51,692
Last modified:September 2, 2008 - v1
Checksum:i2E71E2C662F4CCD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001074 Genomic DNA Translation: ACE90201.1
RefSeqiWP_012483076.1, NC_010994.1

Genome annotation databases

EnsemblBacteriaiACE90201; ACE90201; RHECIAT_CH0001220
KEGGirec:RHECIAT_CH0001220

Similar proteinsi

Entry informationi

Entry nameiBETB_RHIE6
AccessioniPrimary (citable) accession number: B3PTE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: April 25, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health