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B3PTE0

- BETA_RHIE6

UniProt

B3PTE0 - BETA_RHIE6

Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Rhizobium etli (strain CIAT 652)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

    Catalytic activityi

    Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei465 – 4651UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi4 – 3330FADUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
    2. choline dehydrogenase activity Source: UniProtKB-HAMAP
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-1138-MONOMER.
    RETL491916:GH4T-1218-MONOMER.
    UniPathwayiUPA00529; UER00385.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
    Short name:
    CDHUniRule annotation
    Short name:
    CHDUniRule annotation
    Alternative name(s):
    Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betAUniRule annotation
    Ordered Locus Names:RHECIAT_CH0001219
    OrganismiRhizobium etli (strain CIAT 652)
    Taxonomic identifieri491916 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
    ProteomesiUP000008817: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 549549Oxygen-dependent choline dehydrogenasePRO_1000133336Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi491916.RHECIAT_CH0001219.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GMC oxidoreductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2303.
    HOGENOMiHOG000139600.
    KOiK00108.
    OMAiYLQYACT.
    OrthoDBiEOG67HJQP.

    Family and domain databases

    HAMAPiMF_00750. Choline_dehydrogen.
    InterProiIPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view]
    PfamiPF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsiTIGR01810. betA. 1 hit.
    PROSITEiPS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3PTE0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQADFVIIGS GSAGSALAYR LSEDGKNSVL VIEAGGSDFG PFIQMPAALA    50
    WPMSMKRYNW GYLSEPEPNL NNRRITAPRG KVIGGSSSIN GMVYVRGHAE 100
    DFNRWEELGA SGWAYADVLP YFKRMEHSHG GEEGWRGTDG PLHVQRGGFT 150
    NPLFRAFIEA GKQAGFETTD DYNGSKQEGF GLMEQTIFSG RRWSAANAYL 200
    KPALKRKNVG MVYGLARKIV IEDGRATGVE IERGGKVEVV KATREVIVSA 250
    SSFNSPKLLM LSGIGPGQHL NDMGIAVKAD RPGVGANLQD HMEFYFQQVS 300
    TKPVSLYSWL PWFWQGVAGA QWLLSKGGLG ASNQFEACAF LRSAPGLKQP 350
    DIQYHFLPVA ISYDGKAAAK SHGFQVHVGY NLSKSRGSVT LRSPDPKAEP 400
    VLRFNYMSHP EDWEKFRHCV RLTREIFGQT AFDAYRGPEI QPGEGVQSDE 450
    QIDAFLREHL ESAYHPCGTC KMGAKDDPMA VVDPQTRVIG VDGLRVADSS 500
    IFPHVTYGNL NGPSIMTGEK AADHILGKQP LARSNQEPWI NPRAAVSDR 549
    Length:549
    Mass (Da):60,232
    Last modified:September 2, 2008 - v1
    Checksum:iB89528913D04FF8E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001074 Genomic DNA. Translation: ACE90200.1.
    RefSeqiYP_001977378.1. NC_010994.1.

    Genome annotation databases

    EnsemblBacteriaiACE90200; ACE90200; RHECIAT_CH0001219.
    GeneIDi6399306.
    KEGGirec:RHECIAT_CH0001219.
    PATRICi23095858. VBIRhiEtl120572_1186.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001074 Genomic DNA. Translation: ACE90200.1 .
    RefSeqi YP_001977378.1. NC_010994.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 491916.RHECIAT_CH0001219.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACE90200 ; ACE90200 ; RHECIAT_CH0001219 .
    GeneIDi 6399306.
    KEGGi rec:RHECIAT_CH0001219.
    PATRICi 23095858. VBIRhiEtl120572_1186.

    Phylogenomic databases

    eggNOGi COG2303.
    HOGENOMi HOG000139600.
    KOi K00108.
    OMAi YLQYACT.
    OrthoDBi EOG67HJQP.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00385 .
    BioCyci RETL1328306-WGS:GSTH-1138-MONOMER.
    RETL491916:GH4T-1218-MONOMER.

    Family and domain databases

    HAMAPi MF_00750. Choline_dehydrogen.
    InterProi IPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view ]
    Pfami PF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsi TIGR01810. betA. 1 hit.
    PROSITEi PS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome diversity and DNA divergence of Rhizobium etli."
      Gonzalez V., Acosta J.L., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.L., Fernandez J.L., Diaz R., Flores M., Mora J., Palacios R., Davila G.
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CIAT 652.

    Entry informationi

    Entry nameiBETA_RHIE6
    AccessioniPrimary (citable) accession number: B3PTE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3