B3PSC0 (KHSE_RHIE6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	RHECIAT_CH0001057

Organism

Rhizobium etli (strain CIAT 652) [Complete proteome] [HAMAP]

Taxonomic identifier

491916 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Homoserine kinase HAMAP MF_00301		PRO_1000115439

Sequences

	Sequence		Length	Mass (Da)
	B3PSC0 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: 55DC02AE889AA198	FASTA	321	35,834
	10 20 30 40 50 60 MAVYTDIAED DLKWFLSEYD AGSLLSYKGI AEGVENSNFL LHTSKEPLIL TLYEKRVEKT 70 80 90 100 110 120 DLPFFLGLMQ HLAARGLSCP LPLPRRDGAL LGSLSGRPAA LISFLEGMWL RKPEAKHCRE 130 140 150 160 170 180 VGRALAQMHV AGDGFELKRP NALSIDGWRT LWEKSEARAD EVEPGLQHEI RGELDFLSAA 190 200 210 220 230 240 WPKGLPAGVI HADLFPDNVF FLGDQLSGLI DFYFACNDLL AYDVSICLNA WCFEKDGAYN 250 260 270 280 290 300 ITKGTAMLEG YQSVRPLSGE EIAALPVLSR GSALRFFLTR LYDWLTTPEG AMVTKKDPLE 310 320 YLRKLRFHRQ IGSAAEYGLS L

References

[1]

"Genome diversity and DNA divergence of Rhizobium etli." Gonzalez V., Acosta J.L., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.L., Fernandez J.L., Diaz R., Flores M., Mora J., Palacios R., Davila G. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CIAT 652.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001074 Genomic DNA. Translation: ACE90042.1.
RefSeq	YP_001977220.1. NC_010994.1.
3D structure databases
ProteinModelPortal	B3PSC0.
ModBase	Search...
Protein-protein interaction databases
STRING	B3PSC0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6399144.
GenomeReviews	Gene locus thrB in contig CP001074_GR.
KEGG	rec:RHECIAT_CH0001057.
PATRIC	23095559. VBIRhiEtl120572_1039.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_RHIE6

Accession

Primary (citable) accession number: B3PSC0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 2, 2008
Last modified:	January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program