Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rhizobium etli (strain CIAT 652)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei635ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:RHECIAT_CH0004409
OrganismiRhizobium etli (strain CIAT 652)
Taxonomic identifieri491916 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000008817 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000913501 – 876Leucine--tRNA ligaseAdd BLAST876

Interactioni

Protein-protein interaction databases

STRINGi491916.RHECIAT_CH0004409

Structurei

3D structure databases

ProteinModelPortaliB3PS46
SMRiB3PS46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 53"HIGH" regionAdd BLAST11
Motifi632 – 636"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B3PS46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATERYNPRD AEPRWQQKWN EDKVFETDNA DPREKYYVLE MFPYPSGRIH
60 70 80 90 100
MGHVRNYAMG DVVARYKRAR GYNVLHPMGW DAFGMPAENA AMERGVHPAS
110 120 130 140 150
WTYQNIASMK AQLKAMGLSL DWSREFATCD VEYYQHQQHL FLDFLEKGLV
160 170 180 190 200
YRKQSKVNWD PVDNTVLANE QVIDGRGWRS GALVEQRELT QWFFKITDFS
210 220 230 240 250
QDLLDALDTL DQWPEKVRLM QKNWIGRSEG LTVRWEIVPE TAPAGETEIT
260 270 280 290 300
VYTTRPDTLF GASFLAIAAD HPLAKDAAAK NVEIEAFCEE CRRAGTSLAA
310 320 330 340 350
LETAEKKGLD TGIRVRHPLD PTWELPVYIA NFVLMDYGTG AIFGCPSGDQ
360 370 380 390 400
RDLDFARKYG LPVVAVVMPS DGDAASFAVG DTAYDGDGVM INSRFLDGKT
410 420 430 440 450
TEEAFNIVAD RLSAASLGNT PVAERKVNFR LRDWGISRQR YWGCPIPVIH
460 470 480 490 500
CDACGVVPVP KTDLPVKLPE DVTFDQPGNP LDRHPTWRHV TCPHCGKDAR
510 520 530 540 550
RETDTMDTFV DSSWYFTRFT APWEAKPTDP EAANRWLPVD QYIGGIEHAI
560 570 580 590 600
LHLLYSRFFT RAMRETGHVA ASEPFKGLFT QGMVVHETYS RKAGAGREWV
610 620 630 640 650
APADIRIEEI DGKRRALLLA TGEEVAIGSI EKMSKSKKNV VDPDDIIASY
660 670 680 690 700
GADTARFFVL SDSPPERDVI WSEAGVEGAH RFTQRLWRLI SEAAGVLSTV
710 720 730 740 750
AAAPASEGEA LAISQAAHKT LKAVQNDYDK LWFNKAVARI YELVNALAAP
760 770 780 790 800
LTKVAAGEGD IAYRAAVRDA AEILIQLVAP MTPHLAEECW ATLGNTGLLA
810 820 830 840 850
RTGWPRFVEA LVVENDVVLP VQINGKKRAE LTISRDADQN AVTDAVLELD
860 870
AVKNVLNGQA PKKIIVVPQR IVNIVV
Length:876
Mass (Da):97,751
Last modified:September 2, 2008 - v1
Checksum:i486DEF4C54850C8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001074 Genomic DNA Translation: ACE93336.1
RefSeqiWP_012485676.1, NC_010994.1

Genome annotation databases

EnsemblBacteriaiACE93336; ACE93336; RHECIAT_CH0004409
KEGGirec:RHECIAT_CH0004409

Similar proteinsi

Entry informationi

Entry nameiSYL_RHIE6
AccessioniPrimary (citable) accession number: B3PS46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health