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B3PS36

- PUR9_RHIE6

UniProt

B3PS36 - PUR9_RHIE6

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Rhizobium etli (strain CIAT 652)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-4220-MONOMER.
RETL491916:GH4T-4398-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:RHECIAT_CH0004399
OrganismiRhizobium etli (strain CIAT 652)
Taxonomic identifieri491916 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000008817: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Bifunctional purine biosynthesis protein PurHPRO_1000096086Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi491916.RHECIAT_CH0004399.

Structurei

3D structure databases

ProteinModelPortaliB3PS36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B3PS36 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVISKKIPA PDKVEIKTAL LSVFDKTGIV ELAQALSERG VRLLSTGGTY
60 70 80 90 100
KAIATAGLAV TDVSDITGFP EIMDGRVKTL HPTVHGGLLA IRDDSEHQEA
110 120 130 140 150
MKKHGIEGID LAVINLYPFE EVRAAGGDYP TTVENIDIGG PAMIRASAKN
160 170 180 190 200
HAYVTILTDP NDYAEFKEQL SADAGKTAYA FRQRMAAKAY ARTAAYDAAI
210 220 230 240 250
SNWFAEALSI DAPRHRVIGG VLKEEMRYGE NPHQKAAFYV TGEKRPGVST
260 270 280 290 300
AVLLQGKQLS YNNINDTDAA YELVAEFLPE KAPACAIIKH ANPCGVATGS
310 320 330 340 350
SLVEAYRRAL ACDSVSAFGG IIALNQILDA ETAEEIVKLF TEVIIAPDVT
360 370 380 390 400
EEAKAIVVRK PNLRLLSAGG LPDPRVAGLT AKTVSGGLLV QSRDNGMVED
410 420 430 440 450
LELKVVTKRA PTSQELEDMK FAFKVGKHVK SNAVVYAKDG QTAGIGAGQM
460 470 480 490 500
SRVDSARIAA LKAEEAAKAL GLAVPMTKGS AVASEAFLPF ADGLLSMIAA
510 520 530
GATAVIQPGG SMRDQEVIDA ANEHGIAMVF TGMRHFRH
Length:538
Mass (Da):57,111
Last modified:September 2, 2008 - v1
Checksum:iF229615454A478B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001074 Genomic DNA. Translation: ACE93326.1.
RefSeqiWP_012485667.1. NC_010994.1.
YP_001980504.1. NC_010994.1.

Genome annotation databases

EnsemblBacteriaiACE93326; ACE93326; RHECIAT_CH0004399.
GeneIDi6402486.
KEGGirec:RHECIAT_CH0004399.
PATRICi23102280. VBIRhiEtl120572_4351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001074 Genomic DNA. Translation: ACE93326.1 .
RefSeqi WP_012485667.1. NC_010994.1.
YP_001980504.1. NC_010994.1.

3D structure databases

ProteinModelPortali B3PS36.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 491916.RHECIAT_CH0004399.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACE93326 ; ACE93326 ; RHECIAT_CH0004399 .
GeneIDi 6402486.
KEGGi rec:RHECIAT_CH0004399.
PATRICi 23102280. VBIRhiEtl120572_4351.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci RETL1328306-WGS:GSTH-4220-MONOMER.
RETL491916:GH4T-4398-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome diversity and DNA divergence of Rhizobium etli."
    Gonzalez V., Acosta J.L., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.L., Fernandez J.L., Diaz R., Flores M., Mora J., Palacios R., Davila G.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CIAT 652.

Entry informationi

Entry nameiPUR9_RHIE6
AccessioniPrimary (citable) accession number: B3PS36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3