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B3PS36

- PUR9_RHIE6

UniProt

B3PS36 - PUR9_RHIE6

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Rhizobium etli (strain CIAT 652)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-4220-MONOMER.
    RETL491916:GH4T-4398-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:RHECIAT_CH0004399
    OrganismiRhizobium etli (strain CIAT 652)
    Taxonomic identifieri491916 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
    ProteomesiUP000008817: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 538538Bifunctional purine biosynthesis protein PurHPRO_1000096086Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi491916.RHECIAT_CH0004399.

    Structurei

    3D structure databases

    ProteinModelPortaliB3PS36.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B3PS36-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVISKKIPA PDKVEIKTAL LSVFDKTGIV ELAQALSERG VRLLSTGGTY    50
    KAIATAGLAV TDVSDITGFP EIMDGRVKTL HPTVHGGLLA IRDDSEHQEA 100
    MKKHGIEGID LAVINLYPFE EVRAAGGDYP TTVENIDIGG PAMIRASAKN 150
    HAYVTILTDP NDYAEFKEQL SADAGKTAYA FRQRMAAKAY ARTAAYDAAI 200
    SNWFAEALSI DAPRHRVIGG VLKEEMRYGE NPHQKAAFYV TGEKRPGVST 250
    AVLLQGKQLS YNNINDTDAA YELVAEFLPE KAPACAIIKH ANPCGVATGS 300
    SLVEAYRRAL ACDSVSAFGG IIALNQILDA ETAEEIVKLF TEVIIAPDVT 350
    EEAKAIVVRK PNLRLLSAGG LPDPRVAGLT AKTVSGGLLV QSRDNGMVED 400
    LELKVVTKRA PTSQELEDMK FAFKVGKHVK SNAVVYAKDG QTAGIGAGQM 450
    SRVDSARIAA LKAEEAAKAL GLAVPMTKGS AVASEAFLPF ADGLLSMIAA 500
    GATAVIQPGG SMRDQEVIDA ANEHGIAMVF TGMRHFRH 538
    Length:538
    Mass (Da):57,111
    Last modified:September 2, 2008 - v1
    Checksum:iF229615454A478B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001074 Genomic DNA. Translation: ACE93326.1.
    RefSeqiYP_001980504.1. NC_010994.1.

    Genome annotation databases

    EnsemblBacteriaiACE93326; ACE93326; RHECIAT_CH0004399.
    GeneIDi6402486.
    KEGGirec:RHECIAT_CH0004399.
    PATRICi23102280. VBIRhiEtl120572_4351.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001074 Genomic DNA. Translation: ACE93326.1 .
    RefSeqi YP_001980504.1. NC_010994.1.

    3D structure databases

    ProteinModelPortali B3PS36.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 491916.RHECIAT_CH0004399.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACE93326 ; ACE93326 ; RHECIAT_CH0004399 .
    GeneIDi 6402486.
    KEGGi rec:RHECIAT_CH0004399.
    PATRICi 23102280. VBIRhiEtl120572_4351.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci RETL1328306-WGS:GSTH-4220-MONOMER.
    RETL491916:GH4T-4398-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome diversity and DNA divergence of Rhizobium etli."
      Gonzalez V., Acosta J.L., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.L., Fernandez J.L., Diaz R., Flores M., Mora J., Palacios R., Davila G.
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CIAT 652.

    Entry informationi

    Entry nameiPUR9_RHIE6
    AccessioniPrimary (citable) accession number: B3PS36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3