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B3PS36 (PUR9_RHIE6) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:RHECIAT_CH0004399
OrganismRhizobium etli (strain CIAT 652) [Complete proteome] [HAMAP]
Taxonomic identifier491916 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium

Protein attributes

Sequence length538 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 538538Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000096086

Sequences

Sequence LengthMass (Da)Tools
B3PS36 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: F229615454A478B1

FASTA53857,111
        10         20         30         40         50         60 
MAVISKKIPA PDKVEIKTAL LSVFDKTGIV ELAQALSERG VRLLSTGGTY KAIATAGLAV 

        70         80         90        100        110        120 
TDVSDITGFP EIMDGRVKTL HPTVHGGLLA IRDDSEHQEA MKKHGIEGID LAVINLYPFE 

       130        140        150        160        170        180 
EVRAAGGDYP TTVENIDIGG PAMIRASAKN HAYVTILTDP NDYAEFKEQL SADAGKTAYA 

       190        200        210        220        230        240 
FRQRMAAKAY ARTAAYDAAI SNWFAEALSI DAPRHRVIGG VLKEEMRYGE NPHQKAAFYV 

       250        260        270        280        290        300 
TGEKRPGVST AVLLQGKQLS YNNINDTDAA YELVAEFLPE KAPACAIIKH ANPCGVATGS 

       310        320        330        340        350        360 
SLVEAYRRAL ACDSVSAFGG IIALNQILDA ETAEEIVKLF TEVIIAPDVT EEAKAIVVRK 

       370        380        390        400        410        420 
PNLRLLSAGG LPDPRVAGLT AKTVSGGLLV QSRDNGMVED LELKVVTKRA PTSQELEDMK 

       430        440        450        460        470        480 
FAFKVGKHVK SNAVVYAKDG QTAGIGAGQM SRVDSARIAA LKAEEAAKAL GLAVPMTKGS 

       490        500        510        520        530 
AVASEAFLPF ADGLLSMIAA GATAVIQPGG SMRDQEVIDA ANEHGIAMVF TGMRHFRH 

« Hide

References

[1]"Genome diversity and DNA divergence of Rhizobium etli."
Gonzalez V., Acosta J.L., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.L., Fernandez J.L., Diaz R., Flores M., Mora J., Palacios R., Davila G.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CIAT 652.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001074 Genomic DNA. Translation: ACE93326.1.
RefSeqYP_001980504.1. NC_010994.1.

3D structure databases

ProteinModelPortalB3PS36.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING491916.RHECIAT_CH0004399.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACE93326; ACE93326; RHECIAT_CH0004399.
GeneID6402486.
KEGGrec:RHECIAT_CH0004399.
PATRIC23102280. VBIRhiEtl120572_4351.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMADLLFAWK.
OrthoDBEOG6QCDFF.
ProtClustDBPRK00881.

Enzyme and pathway databases

BioCycRETL491916:GH4T-4398-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_RHIE6
AccessionPrimary (citable) accession number: B3PS36
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: February 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways