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B3PQU9 (B3PQU9_RHIE6) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Name:gnd EMBL ACE91522.1
Ordered Locus Names:RHECIAT_CH0002570
OrganismRhizobium etli (strain CIAT 652) [Complete proteome] [HAMAP]
Taxonomic identifier491916 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding17 – 226NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding40 – 423NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding83 – 853NADP By similarity PIRSR PIRSR000109-3
Region137 – 1393Substrate binding By similarity PIRSR PIRSR000109-2
Region194 – 1952Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1911Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1981Proton donor By similarity PIRSR PIRSR000109-1
Binding site1111NADP By similarity PIRSR PIRSR000109-3
Binding site1111Substrate By similarity PIRSR PIRSR000109-2
Binding site1991Substrate By similarity PIRSR PIRSR000109-2
Binding site2691Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2961Substrate By similarity PIRSR PIRSR000109-2
Binding site4551Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4611Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
B3PQU9 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: C8A9DB43BE5A690B

FASTA48352,205
        10         20         30         40         50         60 
MTHRRFVVEK AEIGLIGLAV MGSNLALNIA EKGNKIAVFN RTPEKTDEFY ESAGDLKKQI 

        70         80         90        100        110        120 
IPCKTIEEFV DAIRPPRPII IMIKAGDAVD QQMEALRPHL SKGDIMIDAG NANFRDTVAR 

       130        140        150        160        170        180 
FDRLKDTDLT FIGMGVSGGE EGARHGPSIM VGGTEESWKR VEKVLTSIAA RYNDEPCVAW 

       190        200        210        220        230        240 
LGNDGAGHFV KTIHNGIEYA DMQMIAEIYG ILRDGLGKSA SDISGVFGEW NKGRLNSYLI 

       250        260        270        280        290        300 
EISEKVLAAT DPVSGGPMVD MILDKAGQKG TGKWSAIEAQ NMGIPATAIE AAVAARSLSS 

       310        320        330        340        350        360 
MKSQREAAEK IFGTQAVSFP IAYGPELNKD LELALFAAKI GAYAQGFAVM AEASREFNWS 

       370        380        390        400        410        420 
LPMPTIARIW RAGCIIRSQF LDEITSAFTK APDAANLIVT PAFSEMVKES IPALRRVVAA 

       430        440        450        460        470        480 
AISAGLPVPV LTSALTYFDA YRQGRGTANL IQAQRDFFGA HGFDRLDGKD FHHGPWGSGA 


ATF

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References

[1]"Genome diversity and DNA divergence of Rhizobium etli."
Gonzalez V., Acosta J.L., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.L., Fernandez J.L., Diaz R., Flores M., Mora J., Palacios R., Davila G.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001074 Genomic DNA. Translation: ACE91522.1.
RefSeqYP_001978700.1. NC_010994.1.

3D structure databases

ProteinModelPortalB3PQU9.
ModBaseSearch...

Protein-protein interaction databases

STRINGB3PQU9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6400657.
GenomeReviewsGene locus RHECIAT_CH0002570 in contig CP001074_GR.
KEGGrec:RHECIAT_CH0002570.
PATRIC23098624. VBIRhiEtl120572_2546.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG286913.
OMASNYPDTN.
ProtClustDBPRK09287.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB3PQU9_RHIE6
AccessionPrimary (citable) accession number: B3PQU9
Entry history
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info