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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Rhizobium etli (strain CIAT 652)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase A (rpiA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei105Proton acceptorUniRule annotation1
Binding sitei123SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Short name:
PRIUniRule annotation
Gene namesi
Name:rpiAUniRule annotation
Ordered Locus Names:RHECIAT_CH0002471
OrganismiRhizobium etli (strain CIAT 652)
Taxonomic identifieri491916 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000008817 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000976861 – 232Ribose-5-phosphate isomerase AAdd BLAST232

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi491916.RHECIAT_CH0002471

Structurei

3D structure databases

ProteinModelPortaliB3PPZ4
SMRiB3PPZ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni28 – 31Substrate bindingUniRule annotation4
Regioni83 – 86Substrate bindingUniRule annotation4
Regioni96 – 99Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E66 Bacteria
COG0120 LUCA
HOGENOMiHOG000276369
KOiK01807
OMAiVAPMAYV
OrthoDBiPOG091H059I

Family and domain databases

CDDicd01398 RPI_A, 1 hit
HAMAPiMF_00170 Rib_5P_isom_A, 1 hit
InterProiView protein in InterPro
IPR037171 NagB/RpiA_transferase-like
IPR004788 Ribose5P_isomerase_typA
IPR020672 Ribose5P_isomerase_typA_subgr
PfamiView protein in Pfam
PF06026 Rib_5-P_isom_A, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR00021 rpiA, 1 hit

Sequencei

Sequence statusi: Complete.

B3PPZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAREMKIKA AEAALAHVED GMRLGIGTGS TAEEFVRLLA EKVAGGFRVE
60 70 80 90 100
GVPTSERTAR LCVELGVPLK SLDELPALDL TVDGADEVDP ALRLIKGGGG
110 120 130 140 150
ALLREKIVAA ASERMIVIAD ESKLVDTLGA YALPIEVNPF GLVSTRIAIE
160 170 180 190 200
KVAARLGLSG ELSLRQSGDG EFTTDGGHHI IDASFGRIPD AEALSSELNS
210 220 230
IPGVVEHGLF INMAALAIIA GPAGARTLQA NR
Length:232
Mass (Da):24,171
Last modified:September 2, 2008 - v1
Checksum:iE5750213F984E5F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001074 Genomic DNA Translation: ACE91423.1
RefSeqiWP_012484046.1, NC_010994.1

Genome annotation databases

EnsemblBacteriaiACE91423; ACE91423; RHECIAT_CH0002471
KEGGirec:RHECIAT_CH0002471

Similar proteinsi

Entry informationi

Entry nameiRPIA_RHIE6
AccessioniPrimary (citable) accession number: B3PPZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: April 25, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome