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B3PPT9

- B3PPT9_RHIE6

UniProt

B3PPT9 - B3PPT9_RHIE6

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Rhizobium etli (strain CIAT 652)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei82 – 821NADPUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei210 – 2101Critical for catalysisUniRule annotation
Binding sitei258 – 2581NADPUniRule annotation
Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADPUniRule annotation
Nucleotide bindingi308 – 3136NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciRETL491916:GH4T-2413-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:RHECIAT_CH0002414Imported
OrganismiRhizobium etli (strain CIAT 652)Imported
Taxonomic identifieri491916 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000008817: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi491916.RHECIAT_CH0002414.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OMAiKNTIMKV.
OrthoDBiEOG628F3X.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3PPT9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKIKVANPV ADLDGDEMTR IIWQLIKDKL IHPYLDLDID YYDLSVENRD
60 70 80 90 100
ATNDQVTVDA ANAIKKYGVG IKCATITPDE ARVKEFNLKE MWKSPNGTIR
110 120 130 140 150
NILGGVIFRE PIICRNVPRL VPGWTQPIVV GRHAFGDQYR ATDFKFPGKG
160 170 180 190 200
KLTIKFVGED GTVIEKEVFN APGAGVAMAM YNLDESIREF ARASMMYGLM
210 220 230 240 250
RKWPVYLSTK NTILKAYDGR FKDIFEEVYE TEFKDQFKEA GITYEHRLID
260 270 280 290 300
DMVASALKWS GGYVWACKNY DGDVQSDTVA QGFGSLGLMT SVLLTPDGKT
310 320 330 340 350
VEAEAAHGTV TRHYRQHQKG QETSTNSIAS IFAWTRGLAH RAKLDDNAAL
360 370 380 390 400
AKFASTLEKV CVDTVESGFM TKDLALLIGP DQPWLSTTAF LDKIDQNLQK

AMA
Length:403
Mass (Da):45,078
Last modified:September 2, 2008 - v1
Checksum:i4772D81DA1B7EBE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001074 Genomic DNA. Translation: ACE91368.1.
RefSeqiYP_001978546.1. NC_010994.1.

Genome annotation databases

EnsemblBacteriaiACE91368; ACE91368; RHECIAT_CH0002414.
GeneIDi6400501.
KEGGirec:RHECIAT_CH0002414.
PATRICi23098316. VBIRhiEtl120572_2392.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001074 Genomic DNA. Translation: ACE91368.1 .
RefSeqi YP_001978546.1. NC_010994.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 491916.RHECIAT_CH0002414.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACE91368 ; ACE91368 ; RHECIAT_CH0002414 .
GeneIDi 6400501.
KEGGi rec:RHECIAT_CH0002414.
PATRICi 23098316. VBIRhiEtl120572_2392.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.
OMAi KNTIMKV.
OrthoDBi EOG628F3X.

Enzyme and pathway databases

BioCyci RETL491916:GH4T-2413-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome diversity and DNA divergence of Rhizobium etli."
    Gonzalez V., Acosta J.L., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.L., Fernandez J.L., Diaz R., Flores M., Mora J., Palacios R., Davila G.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CIAT 652Imported.

Entry informationi

Entry nameiB3PPT9_RHIE6
AccessioniPrimary (citable) accession number: B3PPT9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 26, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3