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B3PPT9 (B3PPT9_RHIE6) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Name:icd EMBL ACE91368.1
Ordered Locus Names:RHECIAT_CH0002414 EMBL ACE91368.1
OrganismRhizobium etli (strain CIAT 652) [Complete proteome] [HAMAP] EMBL ACE91368.1
Taxonomic identifier491916 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding308 – 3136NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity

Sites

Metal binding2501Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2731Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2581NADP By similarity PIRSR PIRSR000108-4
Binding site3261NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2101Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
B3PPT9 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: 4772D81DA1B7EBE2

FASTA40345,078
        10         20         30         40         50         60 
MNKIKVANPV ADLDGDEMTR IIWQLIKDKL IHPYLDLDID YYDLSVENRD ATNDQVTVDA 

        70         80         90        100        110        120 
ANAIKKYGVG IKCATITPDE ARVKEFNLKE MWKSPNGTIR NILGGVIFRE PIICRNVPRL 

       130        140        150        160        170        180 
VPGWTQPIVV GRHAFGDQYR ATDFKFPGKG KLTIKFVGED GTVIEKEVFN APGAGVAMAM 

       190        200        210        220        230        240 
YNLDESIREF ARASMMYGLM RKWPVYLSTK NTILKAYDGR FKDIFEEVYE TEFKDQFKEA 

       250        260        270        280        290        300 
GITYEHRLID DMVASALKWS GGYVWACKNY DGDVQSDTVA QGFGSLGLMT SVLLTPDGKT 

       310        320        330        340        350        360 
VEAEAAHGTV TRHYRQHQKG QETSTNSIAS IFAWTRGLAH RAKLDDNAAL AKFASTLEKV 

       370        380        390        400 
CVDTVESGFM TKDLALLIGP DQPWLSTTAF LDKIDQNLQK AMA 

« Hide

References

[1]"Genome diversity and DNA divergence of Rhizobium etli."
Gonzalez V., Acosta J.L., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.L., Fernandez J.L., Diaz R., Flores M., Mora J., Palacios R., Davila G.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CIAT 652 EMBL ACE91368.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001074 Genomic DNA. Translation: ACE91368.1.
RefSeqYP_001978546.1. NC_010994.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING491916.RHECIAT_CH0002414.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACE91368; ACE91368; RHECIAT_CH0002414.
GeneID6400501.
KEGGrec:RHECIAT_CH0002414.
PATRIC23098316. VBIRhiEtl120572_2392.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000019858.
KOK00031.
OMAKNTIMKV.
OrthoDBEOG628F3X.

Enzyme and pathway databases

BioCycRETL491916:GH4T-2413-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB3PPT9_RHIE6
AccessionPrimary (citable) accession number: B3PPT9
Entry history
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: July 9, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)