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B3PP20

- GCSP_RHIE6

UniProt

B3PP20 - GCSP_RHIE6

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, RHECIAT_CH0002352
Organism
Rhizobium etli (strain CIAT 652)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRETL491916:GH4T-2351-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:RHECIAT_CH0002352
OrganismiRhizobium etli (strain CIAT 652)
Taxonomic identifieri491916 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000008817: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_1000132448Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi491916.RHECIAT_CH0002352.

Structurei

3D structure databases

ProteinModelPortaliB3PP20.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B3PP20-1 [UniParc]FASTAAdd to Basket

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MTTPTEFQFT DYQPYDFANR RHIGPSPAEM TDMLKVIGFN SLDGLIDATL    50
PPTIRQKAPL VWGAPMTERE ALDKLRETAN KNKVLVSLIG QGYYGTITPP 100
VIQRNILENP AWYTAYTPYQ PEISQGRLEA LLNYQTMVCD LTGLDVANAS 150
LLDEATAAAE GMAMAERVSK SKAKAFFVDA DCHPQTIALI RTRAEPLGWS 200
VIVGNPFTDL DPVDVFGAIF QYPGTHGHVH DFTGLIARLH QAGAISVVAA 250
DILALTLLKS PGEMGADIAV GSSQRFGVPV GYGGPHAAYM AVKDAIKRSM 300
PGRLVGVSVD ARGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM 350
YAVFHGPDGI KAIAQQVHQK AVLMAKGLEK LGYKVEPESF FDTITVDVGH 400
MQGLILRAAV AEGVNLRKVG ETKIGMSLDE RTRPATLEAV WRAFGGNFTI 450
ADFEPSYLLP KGLLRTTDYL AHPIFHMNRA ESEMTRYIRR LSDRDLALDR 500
SMIPLGSCTM KLNATAEMLP ITWPEFSDIH PFVPADQALG YREMLDDLTE 550
KLCAVTGYDA FSMQPNSGAQ GEYAGLLTIR NYHIANGEGH RDVCLIPTSA 600
HGTNPASAQM VGMKVVVVKV RENGDIDLDD FRTKAEEHAA SLSCCMITYP 650
STHGVFEETV KEICELVHKH GGQVYLDGAN MNAMVGLSRP GDIGSDVSHL 700
NLHKTFCIPH GGGGPGMGPI GVKAHLAPHL PGHPETDGRP GAVSAAAFGS 750
ASILPISWSY CLMMGGEGLT QATKVAILNA NYIAARLKGA YDVLYKSKTG 800
RVAHECIIDT RPLVDSSGVT VDDVAKRLID CGFHAPTMSW PVSGTLMIEP 850
TESETKAELD RFCEAMLAIR EEARAIEDGR MDKINNPLKN APHTVEDLVG 900
EWDRPYSREQ ACFPPGAFRV DKYWSPVNRV DNVYGDRNLI CTCPPVESYA 950
EAAE 954
Length:954
Mass (Da):103,943
Last modified:September 2, 2008 - v1
Checksum:iEECDBC25C2126AA1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001074 Genomic DNA. Translation: ACE91306.1.
RefSeqiYP_001978484.1. NC_010994.1.

Genome annotation databases

EnsemblBacteriaiACE91306; ACE91306; RHECIAT_CH0002352.
GeneIDi6400439.
KEGGirec:RHECIAT_CH0002352.
PATRICi23098192. VBIRhiEtl120572_2330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001074 Genomic DNA. Translation: ACE91306.1 .
RefSeqi YP_001978484.1. NC_010994.1.

3D structure databases

ProteinModelPortali B3PP20.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 491916.RHECIAT_CH0002352.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACE91306 ; ACE91306 ; RHECIAT_CH0002352 .
GeneIDi 6400439.
KEGGi rec:RHECIAT_CH0002352.
PATRICi 23098192. VBIRhiEtl120572_2330.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci RETL491916:GH4T-2351-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome diversity and DNA divergence of Rhizobium etli."
    Gonzalez V., Acosta J.L., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.L., Fernandez J.L., Diaz R., Flores M., Mora J., Palacios R., Davila G.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CIAT 652.

Entry informationi

Entry nameiGCSP_RHIE6
AccessioniPrimary (citable) accession number: B3PP20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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