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B3PN19

- SYE_MYCA5

UniProt

B3PN19 - SYE_MYCA5

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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Mycoplasma arthritidis (strain 158L3-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei256 – 2561ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMART243272:GHIZ-483-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:MARTH_orf641
OrganismiMycoplasma arthritidis (strain 158L3-1)
Taxonomic identifieri243272 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000008812: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464Glutamate--tRNA ligasePRO_1000090090Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi243272.MARTH_orf641.

Structurei

3D structure databases

ProteinModelPortaliB3PN19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi11 – 2111"HIGH" regionAdd
BLAST
Motifi253 – 2575"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000252720.
KOiK01885.
OMAiWLPEEMG.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3PN19-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKTIRTRYA PSPTGYLHIG GARTALFCYL FAKHSNGDFI FRLEDTDVER
60 70 80 90 100
NVEGGEASQL NNLAWLGIVP DESPLKPNPK YGKYRQSEKL AIYQAYIDEL
110 120 130 140 150
IKQGLAYKAY DSSEELAKQH EEQEKAGVAS FRYDPTWLKL SESEIKRRDE
160 170 180 190 200
AKEYSIRLKL PKNKNYSWDD LVRGPISVNS DDIGDFVIMK SDGYPTYNFA
210 220 230 240 250
VVVDDHQMDI THVLRGEEHI TNTPKQLAIY EAFGWDNPVF GHLTIITNME
260 270 280 290 300
GKKLSKRDKS LKQFIEDYKN EGYCPEAIFN FLALLGWTSG DKTEIMSHDE
310 320 330 340 350
LIKKFDYNRL SKSPSKFDIV KMEWFSKQYM KKLPNEVIIE KINSPKDAQW
360 370 380 390 400
NNLFVETYKQ QAATISEIKE NLKIYLFPKE KLELQIDNDL VVKTFFAHLK
410 420 430 440 450
AKDFTIENIQ AAIDETKNAL NVKGKDLFMP IRITATYEEH GPELAKAIYL
460
FGKDLVYKRL TKWS
Length:464
Mass (Da):53,707
Last modified:September 2, 2008 - v1
Checksum:i151CEA98284D39AE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001047 Genomic DNA. Translation: ACF07421.1.
RefSeqiWP_012498378.1. NC_011025.1.
YP_002000125.1. NC_011025.1.

Genome annotation databases

EnsemblBacteriaiACF07421; ACF07421; MARTH_orf641.
GeneIDi6418126.
KEGGimat:MARTH_orf641.
PATRICi20004069. VBIMycArt31993_0460.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001047 Genomic DNA. Translation: ACF07421.1 .
RefSeqi WP_012498378.1. NC_011025.1.
YP_002000125.1. NC_011025.1.

3D structure databases

ProteinModelPortali B3PN19.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243272.MARTH_orf641.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF07421 ; ACF07421 ; MARTH_orf641 .
GeneIDi 6418126.
KEGGi mat:MARTH_orf641.
PATRICi 20004069. VBIMycArt31993_0460.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000252720.
KOi K01885.
OMAi WLPEEMG.
OrthoDBi EOG6DRPF7.

Enzyme and pathway databases

BioCyci MART243272:GHIZ-483-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 158L3-1.

Entry informationi

Entry nameiSYE_MYCA5
AccessioniPrimary (citable) accession number: B3PN19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3