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B3PM40 (KITH_MYCA5) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:tdk
Ordered Locus Names:MARTH_orf165
OrganismMycoplasma arthritidis (strain 158L3-1) [Complete proteome] [HAMAP]
Taxonomic identifier243272 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00124

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00124.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 194194Thymidine kinase HAMAP-Rule MF_00124
PRO_1000095434

Regions

Nucleotide binding15 – 228ATP By similarity
Nucleotide binding89 – 924ATP By similarity

Sites

Active site901Proton acceptor Potential
Metal binding1461Zinc By similarity
Metal binding1491Zinc By similarity
Metal binding1781Zinc By similarity
Metal binding1811Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
B3PM40 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: FA475CE8D51367D0

FASTA19422,215
        10         20         30         40         50         60 
MYKNFNEGMI EVITGPMFSG KSEELLKRIR TLEYAKLKPL VIKPEFDTRF SENEIVSRAG 

        70         80         90        100        110        120 
VKHKTHILKN INDVYFLLQE DKYKAVVIDE AHWFNEELVK VADDLANKGY LVIVAGLDQN 

       130        140        150        160        170        180 
YLREPFGPIP NLLAIAERVT KLQAICVKCQ HAASTSFRKV AASEINLLGD FQEYEARCRK 

       190 
CHNAGQKEKL QKKV 

« Hide

References

[1]"Genome of Mycoplasma arthritidis."
Dybvig K., Zuhua C., Lao P., Jordan D.S., French C.T., Tu A.H., Loraine A.E.
Infect. Immun. 76:4000-4008(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 158L3-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001047 Genomic DNA. Translation: ACF07092.1.
RefSeqYP_001999796.1. NC_011025.1.

3D structure databases

ProteinModelPortalB3PM40.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243272.MARTH_orf165.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACF07092; ACF07092; MARTH_orf165.
GeneID6418251.
KEGGmat:MARTH_orf165.
PATRIC20003351. VBIMycArt31993_0126.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1435.
HOGENOMHOG000076390.
KOK00857.
OMAKVHAICV.
OrthoDBEOG69D3J2.
ProtClustDBPRK04296.

Enzyme and pathway databases

BioCycMART243272:GHIZ-128-MONOMER.

Family and domain databases

HAMAPMF_00124. Thymidine_kinase.
InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_MYCA5
AccessionPrimary (citable) accession number: B3PM40
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: April 16, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families