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Protein

Thymidine kinase

Gene

tdk

Organism
Mycoplasma arthritidis (strain 158L3-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei90Proton acceptorUniRule annotation1
Metal bindingi146ZincUniRule annotation1
Metal bindingi149ZincUniRule annotation1
Metal bindingi178ZincUniRule annotation1
Metal bindingi181ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22ATPUniRule annotation8
Nucleotide bindingi89 – 92ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processDNA synthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciMART243272:G1GBT-124-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:MARTH_orf165
OrganismiMycoplasma arthritidis (strain 158L3-1)
Taxonomic identifieri243272 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000008812 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000954341 – 194Thymidine kinaseAdd BLAST194

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi243272.MARTH_orf165

Structurei

3D structure databases

ProteinModelPortaliB3PM40
SMRiB3PM40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T8J Bacteria
COG1435 LUCA
HOGENOMiHOG000076390
KOiK00857
OMAiKEQFGWI
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

B3PM40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKNFNEGMI EVITGPMFSG KSEELLKRIR TLEYAKLKPL VIKPEFDTRF
60 70 80 90 100
SENEIVSRAG VKHKTHILKN INDVYFLLQE DKYKAVVIDE AHWFNEELVK
110 120 130 140 150
VADDLANKGY LVIVAGLDQN YLREPFGPIP NLLAIAERVT KLQAICVKCQ
160 170 180 190
HAASTSFRKV AASEINLLGD FQEYEARCRK CHNAGQKEKL QKKV
Length:194
Mass (Da):22,215
Last modified:September 2, 2008 - v1
Checksum:iFA475CE8D51367D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001047 Genomic DNA Translation: ACF07092.1
RefSeqiWP_012498049.1, NC_011025.1

Genome annotation databases

EnsemblBacteriaiACF07092; ACF07092; MARTH_orf165
KEGGimat:MARTH_orf165

Similar proteinsi

Entry informationi

Entry nameiKITH_MYCA5
AccessioniPrimary (citable) accession number: B3PM40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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