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Protein

UvrABC system protein B

Gene

uvrB

Organism
Mycoplasma arthritidis (strain 158L3-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 46ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease, Helicase, Hydrolase
Biological processDNA damage, DNA excision, DNA repair, SOS response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein BUniRule annotation
Short name:
Protein UvrBUniRule annotation
Alternative name(s):
Excinuclease ABC subunit BUniRule annotation
Gene namesi
Name:uvrBUniRule annotation
Ordered Locus Names:MARTH_orf076
OrganismiMycoplasma arthritidis (strain 158L3-1)
Taxonomic identifieri243272 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000008812 Componenti: Chromosome

Subcellular locationi

B3PLX9:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000995561 – 660UvrABC system protein BAdd BLAST660

Interactioni

Subunit structurei

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi243272.MARTH_orf076.

Structurei

3D structure databases

ProteinModelPortaliB3PLX9.
SMRiB3PLX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 196Helicase ATP-bindingUniRule annotationAdd BLAST171
Domaini431 – 593Helicase C-terminalUniRule annotationAdd BLAST163
Domaini622 – 657UVRUniRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi92 – 115Beta-hairpinAdd BLAST24

Domaini

The beta-hairpin motif is involved in DNA binding.UniRule annotation

Sequence similaritiesi

Belongs to the UvrB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CCW. Bacteria.
COG0556. LUCA.
HOGENOMiHOG000073580.
KOiK03702.
OMAiRYMHSEI.
OrthoDBiPOG091H02LK.

Family and domain databases

CDDicd00079. HELICc. 1 hit.
Gene3Di4.10.860.10. 1 hit.
HAMAPiMF_00204. UvrB. 1 hit.
InterProiView protein in InterPro
IPR006935. Helicase/UvrB_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR036876. UVR_dom_sf.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
PANTHERiPTHR24029. PTHR24029. 1 hit.
PfamiView protein in Pfam
PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00631. uvrb. 1 hit.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.

Sequencei

Sequence statusi: Complete.

B3PLX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEKFVLHSP FAPSGDQPEA IKALVDGIDE KKEHQVLLGV TGSGKTFTIA
60 70 80 90 100
NVIAQLNRPS LIISHNKTLA SQLYSELKAL FPDNRVEYFV SYFDFYKPEA
110 120 130 140 150
YIPKSDLYIE KTSKNNKELE AMRMSAINAL SIRKDTIVVA SVAAIYGESN
160 170 180 190 200
PKHYRQNFFP IEVGMQIDRK SLLLKLSQIG YERNRMELNK GQFDVKGDSI
210 220 230 240 250
EICPGYVSDT NIRIDMFGNE IEAITLIDPL SKNVEGSRKN MTLFPATTYT
260 270 280 290 300
VHENTIQNTV DLIKQELSER IEYFKSHDKL LEAQRIKDRT LNDLDSLLEF
310 320 330 340 350
GYTSGIENYS RYLDGRAPGQ RPYTLFDYLP DDSVIFIDES HLMIPQLHGM
360 370 380 390 400
HNGDRARKLS LVEYGFRLPS ALDNRPLRFE EFAEFKFPKI YISATPGDYE
410 420 430 440 450
LDLTHGEIVT QYIRPTGLLD PIIEIHSRDN QIEDIYDHLK EQIAKKERTL
460 470 480 490 500
ILTTTKKNAE ELSLFLQEKK IKSAYIHDRF KIFERNEILK GLRMGKFDVV
510 520 530 540 550
VGINLLKEGI DLPEVSLICV LNADSTGLMR DTRSLIQIVG RAARNDHGKV
560 570 580 590 600
IFYANEITSS MRECIEDNLF KRKIQSEYNE KHNIIPKTIV KPIAPPIQNG
610 620 630 640 650
ILSEDHSKYY GEKDLSQMKH NKKFIDQMVR KMTQLAKANK FEEAIEIRDY
660
LIEIGIELDK
Length:660
Mass (Da):75,885
Last modified:September 2, 2008 - v1
Checksum:i33A5AF375705367D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001047 Genomic DNA. Translation: ACF07031.1.
RefSeqiWP_012497988.1. NC_011025.1.

Genome annotation databases

EnsemblBacteriaiACF07031; ACF07031; MARTH_orf076.
KEGGimat:MARTH_orf076.

Similar proteinsi

Entry informationi

Entry nameiUVRB_MYCA5
AccessioniPrimary (citable) accession number: B3PLX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: October 25, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families