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B3PIB4

- SYL_CELJU

UniProt

B3PIB4 - SYL_CELJU

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Cellvibrio japonicus (strain Ueda107) (Pseudomonas fluorescens subsp. cellulosa)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei625 – 6251ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCJAP498211:GHIT-454-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:CJA_0454
    OrganismiCellvibrio japonicus (strain Ueda107) (Pseudomonas fluorescens subsp. cellulosa)
    Taxonomic identifieri498211 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeCellvibrio
    ProteomesiUP000001036: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 864864Leucine--tRNA ligasePRO_1000091301Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi498211.CJA_0454.

    Structurei

    3D structure databases

    ProteinModelPortaliB3PIB4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi622 – 6265"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3PIB4-1 [UniParc]FASTAAdd to Basket

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    MQEQYNPAEV EAQAQQYWEE HQSFNVIEDP GKEKFYCLAM FPYPSGKLHM    50
    GHVRNYTITD VIARYQRMQG KNVLHPMGWD AFGLPAENAA LKHNTAPAKW 100
    TYSNTDHMRN QLKQLGFGFD WSRELTTCKP EYYQWEQWFF TRLYEKGLVY 150
    KKMSTVNWDP IDQTVLANEQ VIDGRGWRSG ALVERKEIPQ WFIKITDYAE 200
    ELLNDLDKLP NWPEQVKTMQ RNWIGKSRGL EMRFDLQSPV GEFTSFDIYT 250
    TRPDTLMGVT YVSLAAEHPI AKYLADSNPA LAQFIADCKV QSVAEADMAT 300
    MEKKGMDTGI KALHPITGEP VAVWVANYVL MDYGSGAVMA VPAHDQRDYE 350
    FAQKYHLGIT QVIAPQNGET IDLSQAAFTD KGVLVNSGEY DGLDFNAAFD 400
    AIASTLEMAN KGRVKTNYRL RDWGVSRQRY WGAPIPMFNL PEGGEIPVPA 450
    HKLPILLPEE VVMNGVQSPI KADPEWKKDE LDGQYVERET DTFDTFMESS 500
    WYYARYTCPN FTDGMINKAA ADYWLPVDQY VGGIEHAILH LLYSRFFHKL 550
    MRDEGLVSGD EPFERLLCQG MVNAESFFIK SEGKENWIEP ENVVIERDDK 600
    GRFIAAKHKI TGDAVEFGGV IKMSKSKANG VDPESVINQY GADTVRLFTM 650
    FAAPPEQSLE WSDSGVEGAS RFLRRLWKAV EGHINAGTPG KLDAASLPQQ 700
    QKDLRRKTHE TIQKVSDDYG RRQTFNTAIA AVMELLNETS KLSDRANPQG 750
    LAVEREALEA AILLLAPIVP HITQALWIEL GNSGIPLNQP WPTLDESALV 800
    RSTIEVVVQV NGKLRGKIDA AVDAPKELLE QIAVQQENVQ KFLEGVTVRK 850
    VIVVPNKLVN IVAN 864
    Length:864
    Mass (Da):97,610
    Last modified:September 2, 2008 - v1
    Checksum:iEBC31552266D6203
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000934 Genomic DNA. Translation: ACE83294.1.
    RefSeqiWP_012486134.1. NC_010995.1.
    YP_001980977.1. NC_010995.1.

    Genome annotation databases

    EnsemblBacteriaiACE83294; ACE83294; CJA_0454.
    GeneIDi6414491.
    KEGGicja:CJA_0454.
    PATRICi21324289. VBICelJap122165_0464.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000934 Genomic DNA. Translation: ACE83294.1 .
    RefSeqi WP_012486134.1. NC_010995.1.
    YP_001980977.1. NC_010995.1.

    3D structure databases

    ProteinModelPortali B3PIB4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 498211.CJA_0454.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACE83294 ; ACE83294 ; CJA_0454 .
    GeneIDi 6414491.
    KEGGi cja:CJA_0454.
    PATRICi 21324289. VBICelJap122165_0464.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CJAP498211:GHIT-454-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Insights into plant cell wall degradation from the genome sequence of the soil bacterium Cellvibrio japonicus."
      DeBoy R.T., Mongodin E.F., Fouts D.E., Tailford L.E., Khouri H., Emerson J.B., Mohamoud Y., Watkins K., Henrissat B., Gilbert H.J., Nelson K.E.
      J. Bacteriol. 190:5455-5463(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ueda107.

    Entry informationi

    Entry nameiSYL_CELJU
    AccessioniPrimary (citable) accession number: B3PIB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3