Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Catalase-peroxidase 2

Gene

katG2

Organism
Cellvibrio japonicus (strain Ueda107) (Pseudomonas fluorescens subsp. cellulosa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei103 – 1031Transition state stabilizerUniRule annotation
Active sitei107 – 1071Proton acceptorUniRule annotation
Metal bindingi269 – 2691Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciCJAP498211:GHIT-25-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 2UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 2UniRule annotation
Alternative name(s):
Peroxidase/catalase 2UniRule annotation
Gene namesi
Name:katG2UniRule annotation
Ordered Locus Names:CJA_0025
OrganismiCellvibrio japonicus (strain Ueda107) (Pseudomonas fluorescens subsp. cellulosa)
Taxonomic identifieri498211 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCellvibrionalesCellvibrionaceaeCellvibrio
Proteomesi
  • UP000001036 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727UniRule annotationAdd
BLAST
Chaini28 – 740713Catalase-peroxidase 2PRO_0000354756Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki106 ↔ 228Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-254)UniRule annotation
Cross-linki228 ↔ 254Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-106)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiB3PEP6.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi498211.CJA_0025.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B3PEP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKKTKPRIS ILALTISCAI YSGAALAQDA ANSNKFWWPE QLNLSPLRQH
60 70 80 90 100
GVESNPMGST FNYAQAFKKL DLNAVKADIK ALMTQSQDWW PADYGHYGPF
110 120 130 140 150
FIRMAWHSAG TYRIYDGRGG AGGGQQRFEP LNSWPDNVNL DRARRLLWPI
160 170 180 190 200
KQKYGSSISW ADLMVLTGNV ALESMGFKTF GFAGGRQDDW EADTVYWGPE
210 220 230 240 250
KKWLDDKRYS GDRTLEKPLA AVQMGLIYVN PEGPNGVPDP LLAAKDIRDT
260 270 280 290 300
FGRMAMNDEE TVALIAGGHT FGKAHGAHKP ETCLGKEPAA AGIEEQGLGW
310 320 330 340 350
TNKCGKGNAE DTITSGLEGA WSVNPIAWTT QYLDNLFAFE WVQVRSPAGA
360 370 380 390 400
VQWIPKDGQA ANLVPDAHDK TKRHAPIMFT TDLALKEDPE YRKISLRFKE
410 420 430 440 450
NPKEFELAFA KAWFKLTHRD MGPRVRYLGN EVPGEILLWQ DPVPEVDHPL
460 470 480 490 500
IDAADITKLK SSLLSSGLSS AELVRTAWAA AASFRGTDLR GGANGARIRL
510 520 530 540 550
APQNTWAVNN PRELNRALTR LEKVQGDFNK ASTGGKKVSL ADVIVLGGVA
560 570 580 590 600
AVEQAAKKAG YAVEVPFIPG RTDASQAQTD VTSFAVLEPT ADGFRNYYAK
610 620 630 640 650
DNTLPPTDML VERANLLTLT VPEMTVLVGG LRVLGANSDA AKNGIFTDKP
660 670 680 690 700
GTLSNDFFIN LLDMSTQWRK SAKTGGLYEG LDRKTGKLKW TATPVDLIFG
710 720 730 740
SHSELRAVAE VYAANDGQEK FVNDFVKAWH KVMMLDRFDW
Length:740
Mass (Da):81,550
Last modified:September 2, 2008 - v1
Checksum:i2FD3F6FC1791C1DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000934 Genomic DNA. Translation: ACE85973.1.
RefSeqiWP_012485709.1. NC_010995.1.

Genome annotation databases

EnsemblBacteriaiACE85973; ACE85973; CJA_0025.
KEGGicja:CJA_0025.
PATRICi21323413. VBICelJap122165_0026.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000934 Genomic DNA. Translation: ACE85973.1.
RefSeqiWP_012485709.1. NC_010995.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi498211.CJA_0025.

Proteomic databases

PRIDEiB3PEP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACE85973; ACE85973; CJA_0025.
KEGGicja:CJA_0025.
PATRICi21323413. VBICelJap122165_0026.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.
OrthoDBiPOG091H05R1.

Enzyme and pathway databases

BioCyciCJAP498211:GHIT-25-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG2_CELJU
AccessioniPrimary (citable) accession number: B3PEP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: September 2, 2008
Last modified: September 7, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.