Reviewed, UniProtKB/Swiss-Prot B3PC16 (PUR7_CELJU)

Names and origin

Protein names

Recommended name:
    Phosphoribosylaminoimidazole-succinocarboxamide synthase
    EC=6.3.2.6
Alternative name(s):
    SAICAR synthetase

Gene names

Name:	purC
Ordered Locus Names:	CJA_2827

Organism

Cellvibrio japonicus (strain Ueda107) [Complete proteome] [HAMAP]

Taxonomic identifier

498211 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Cellvibrio

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 236	236	Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137		PRO_1000095968

Sequences

	Sequence		Length	Mass (Da)
	B3PC16-1 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: 2F65D27EA3ACAD7E	FASTA	236	26,799
	10 20 30 40 50 60 MEKREQLYAG KAKSIFNTDD PDHLVMLFRN DTSAFDGKRV EQLDRKGMVN NKFNAFIMGK 70 80 90 100 110 120 LQAAGIPTHF VKLLSDTEAL VKKMDMIPVE CVVRNLAAGS LVRRLGVQEG QVLNPPTFEL 130 140 150 160 170 180 FLKNDALGDP MINESHVESF GWATREQLAR MKELTFKINE VLKDLFAAGN MLLVDFKVEF 190 200 210 220 230 GLHKGEVILG DEFSPDGCRL WDKDTREKLD KDRFRQNLGN VVESYELVGQ RLGLTF

References

[1]

"Insights into plant cell wall degradation from the genome sequence of the soil bacterium Cellvibrio japonicus." DeBoy R.T., Mongodin E.F., Fouts D.E., Tailford L.E., Khouri H., Emerson J.B., Mohamoud Y., Watkins K., Henrissat B., Gilbert H.J., Nelson K.E. J. Bacteriol. 190:5455-5463(2008) [PubMed: 18556790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000934 Genomic DNA. Translation: ACE84580.1.
RefSeq	YP_001983286.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6413930.
GenomeReviews	Gene locus CJA_2827 in contig CP000934_GR.
KEGG	cja:CJA_2827.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG306070.
OMA	TAFNAQK.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synt. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR00081. purC. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. PS01058. SAICAR_SYNTHETASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR7_CELJU

Accession

Primary (citable) accession number: B3PC16

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 2, 2008
Last modified:	February 9, 2010
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)